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Segmental ureterectomy is not inferior to radical nephroureterectomy for either middle or distal ureter urothelial cell carcinomas within 3.5 cm

  • Urology - Original Paper
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Abstract

Objective

To evaluate oncologic outcomes of segmental ureterectomy (SU) compared with radical nephroureterectomy (RNU) for urothelial carcinoma of ureter. To evaluate whether tumor position is a factor to influence outcomes of different surgical procedures.

Methods

From November 2003 to June 2016, 131 patients with urothelial carcinoma of ureter underwent SU or RNU at our department. We used survival analysis and Cox regression models to compare oncologic outcomes after SU and RNU. Covariates included surgical type, tumor stage, cancer grade, lesion position, presence of preoperative hydronephrosis and histories of bladder cancer. Patients were divided according to lesion sites for further comparison.

Results

The mean length of follow-up was 55.3 and 50.9 months for the RNU and SU group, respectively. The bladder recurrences, local recurrences, distant metastasis, cancer-specific survival and overall survival rates showed no significant differences between RNU and SU (p = 0.596, p = 0.636, p = 0.740, p = 0.809, p = 0.553, respectively). For mid-ureter or distal ureter lesions, no significant difference of oncologic outcomes between SU and RUN was observed.

Conclusions

Our study suggested SU is not inferior to RNU for either middle or distal ureter urothelial cell carcinomas.

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Acknowledgements

Funding was provided by National Natural Science Foundation of China (Grant No. 81472379).

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Author notes

  1. Chen Fang and Xin Xie have contributed equally to this work.

Authors and Affiliations

  1. Department of Urology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No. 197, 2nd Ruijin Road, Shanghai, 200025, China

    Chen Fang, Xin Xie, Tianyuan Xu, Wei He, Hongchao He, Xiaojing Wang, Yu Zhu, Zhoujun Shen & Yuan Shao

  2. Department of Urology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, China

    Yuan Shao

Authors
  1. Chen Fang
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  2. Xin Xie
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  3. Tianyuan Xu
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  4. Wei He
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  5. Hongchao He
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  6. Xiaojing Wang
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  7. Yu Zhu
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  8. Zhoujun Shen
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  9. Yuan Shao
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Corresponding author

Correspondence to Yuan Shao.

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Fang, C., Xie, X., Xu, T. et al. Segmental ureterectomy is not inferior to radical nephroureterectomy for either middle or distal ureter urothelial cell carcinomas within 3.5 cm. Int Urol Nephrol 49, 1177–1182 (2017). https://doi.org/10.1007/s11255-017-1576-0

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  • DOI: https://doi.org/10.1007/s11255-017-1576-0

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