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Torque teno virus infection in hemodialysis patients in North India

  • Nephrology - Original Paper
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Abstract

This study describes the prevalence and association of Torque teno virus (TTV) infection with blood-transmitted viral hepatitis including hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in patients with chronic renal failure (CRF) on maintenance hemodialysis (HD). TTV infection was diagnosed by detection of TTV-DNA in serum, using the polymerase chain reaction (PCR) technique. TTV-DNA was estimated in a total number of one hundred patients with CRF and in 100 voluntary blood donors as controls. The markers of HBV and HCV were also tested in sera samples of these patients. TTV-DNA was detected in 39 of 100 patients (39%) with CRF and in 27 of 100 (27%) healthy controls. The analysis of the results demonstrated HBsAg, IgM anti-HBc, anti-HCV, and HCV core antigen in 5.0, 3.0, 6.0, and 4.0% of patients, respectively. This study could not show any association of TTV with HBV and HCV infections for the transmission pattern or any impact on severity of diseases caused by these viruses in CRF patients. TTV also could not show any association with demographic characteristics of patients, duration of dialysis, number of blood transfusions and renal/liver function of the patients. As such, this study concludes that TTV appears as a benign pathogen, showing no sign of renal/liver damage or any change in the severity of diseases caused by blood-borne hepatitis viruses.

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Acknowledgments

The authors thank and appreciate the financial aid provided by ICMR, New Delhi, India to conduct this study. Authors are also thankful to Mrs. Suman Rawat for preparing this manuscript and Mr. Surendra Singh for the help in test performance.

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Authors and Affiliations

  1. Clinical Biochemistry Division, Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, 110029, India

    Mohammad Irshad, Kishore Mandal & Shiwani Singh

  2. Department of Nephrology, All India Institute of Medical Sciences, New Delhi, 110029, India

    S. K. Agarwal

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  1. Mohammad Irshad
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  2. Kishore Mandal
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  3. Shiwani Singh
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  4. S. K. Agarwal
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Correspondence to Mohammad Irshad.

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Irshad, M., Mandal, K., Singh, S. et al. Torque teno virus infection in hemodialysis patients in North India. Int Urol Nephrol 42, 1077–1083 (2010). https://doi.org/10.1007/s11255-009-9648-4

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  • DOI: https://doi.org/10.1007/s11255-009-9648-4

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