Abstract
The birth of the first transgenic primate to have inherited a transgene from its parents opens the possibility to set up transgenic marmoset colonies, as these monkeys are small and relatively easy to keep and breed in research facilities. The prospect of transgenic marmoset models of human disease, readily available in the way that transgenic laboratory mice are currently, prompts excitement in the scientific community; but the idea of monkeys being bred to carry diseases is also contentious. We structure an ethical analysis of the transgenic marmoset case around three questions: whether it is acceptable to use animals as models of human disease; whether it is acceptable to genetically modify animals; and whether these animals’ being monkeys makes a difference. The analysis considers the prospect of transgenic marmoset studies coming to replace transgenic mouse studies and lesion studies in marmosets in some areas of research. The mainstream, broadly utilitarian view of animal research suggests that such a transition will not give rise to greater ethical problems than those presently faced. It can be argued that using marmosets rather than mice will not result in more animal suffering, and that the benefits of research will improve with a move to a species more similar in phylogenetic terms to humans. The biological and social proximity of monkeys and humans may also benefit the animals by making it easier for scientists and caretakers to recognize signs of suffering and increasing the human motivation to limit it. The animal welfare and research impacts of the transition to marmoset use will depend very much on the extent to which researchers take these issues seriously and seek to minimize animal harm and optimize human benefit.
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References
Aldhous P, Coghlan A, Copley J (1999) Let the people speak. New Sci 2187:26
Anonymous (2009) Time to connect (editorial). Nature 459:483
Arluke A, Sanders CR (1996) Regarding animals. Temple University Press, Philadelphia
Byrne RW (2000) Evolution of primate cognition. Cognitive Sci 24:543–570
Chan AWS, Chong KY, Martinovich C, Simerly C, Schatten G (2001) Transgenic monkeys produced by retroviral gene transfer into mature oocytes. Science 291:309–312
ESF-EMRC (2009) Position on the proposal for a directive on the protection of animals used for scientific purposes, 2nd edn. European Science Foundation, Strasbourg. http://www.esf.org/research-areas/medicalsciences/activities/science-policy/animal-protection-in-biomedical-research.html
Gjerris M, Olsson A, Sandøe P (2006) Animal biotechnology and animal welfare. In: Ethical eye: animal welfare. Council of Europe, Strasbourg. http://book.coe.int/EN/ficheouvrage.php?PAGEID=36&lang=EN&produit_aliasid=2115
Holtug N. (1993) Human gene therapy: Down the slippery slope? Bioethics 7(5):402–419. doi:10.1111/j.1467-8519.1993.tb00231.x
Jennings M, Prescott MJ (2009) Refinements in husbandry, care and common procedures for non-human primates. Ninth report of the BCVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement. Lab Anim-UK S1 47 pp
Lassen J, Gjerris M, Sandøe P (2006) After Dolly—ethical limits to the use of biotechnology on farm animals. Theriogenology 65:992–1004
Mansfield K (2003) Marmoset models commonly used in biomedical research. Comparative Med 53:383–392
Markou A, Chiamulera C, Geyer MA, Tricklebank M, Steckler T (2009) Removing obstacles in neuroscience drug discovery: the future path for animal models. Neuropsychopharmacology 34:74–89
Olsson IAS, Hansen AK, Sandøe P (2007) Ethics and refinement in animal research. Science 317:1680
Olsson IAS, Hansen AK, Sandøe P (2008) Animal welfare and the refinement of neuroscience research methods—a case study of Huntington’s disease models. Lab Anim-UK 42:277–283
Prescott MJ, Buchanan-Smith HM (2007) Training laboratory-housed non-human primates, part I: a UK survey. Anim Welfare 16:21–36
Reiss D, Marino L (2001) Mirror self-recognition in the bottlenose dolphin: a case of cognitive convergence. PNAS 8:5937–5942
Richardson CA, Flecknell PA (2005) Anaesthesia and post-operative analgesia following experimental surgery in laboratory rodents: are we making progress? ATLA Altern Lab Anim 33:119–127
Russell WMS, Burch RL (1959) The principles of humane experimental technique. http://altweb.jhsph.edu/publications/humane_exp/het-toc.htm Accessed 23 July 2009
Sandøe P, Christiansen SB (2008) Ethics of animal use. Blackwell, Oxford
Sasaki E, Suemizu H, Shimada A, Hanazawa K, Oiwa R, Kamioka M, Tomioka I, Sotomaru Y, Hirakawa R, Eto T, Shiozawa S, Maeda T, Ito M, Ito R, Kito C, Yagihashi C, Kawai K, Miyoshi H, Tanioka Y, Tamaoki N, Habu S, Okano H, Nomura T (2009) Generation of transgenic non-human primates with germline transmission. Nature 459:523–527
Schatten G, Mitalipov S (2009) Transgenic primate offspring. Nature 459:515–516
Sena E, van der Worp HB, Howells D, Macleod M (2007) How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci 30:433–439
Shapiro KJ (1998) Animal models of human psychology. Critique of science, ethics and policy. Hogrefe and Huber, Göttingen
Smith JA, Boyd KM (1991) Lives in the balance: the ethics of using animals in biomedical research. Oxford University Press, Oxford
Smith D, Trennery P, Farningham D, Klapwijk J (2001) The selection of marmoset monkeys (Callithrix jacchus) in pharmaceutical toxicology. Lab Anim-UK 35:117–130
Vitale A, Manciocci A, Alleva E (2009) The 3R principle and the use of non-human primates in the study of neurodegenerative diseases: The case of Parkinson’s disease. Neurosci Biobehav R 33:33–47
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The authors wish to thank Paul Robinson and an anonymous referee for comments on an earlier version of this manuscript. This paper was prepared within the EC NEST029025 project INTEGRA.
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Olsson, I.A.S., Sandøe, P. “What’s wrong with my monkey?” Ethical perspectives on germline transgenesis in marmosets. Transgenic Res 19, 181–186 (2010). https://doi.org/10.1007/s11248-009-9316-6
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DOI: https://doi.org/10.1007/s11248-009-9316-6