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A copper(II) complex of a semicarbazone: crystal structure, spectroscopic analysis and cytotoxicity against human cancer cell lines

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Abstract

A Cu(II) complex of 2-hydroxyacetophenone N(4)-phenyl semicarbazone (H2L) has been prepared, and its crystal structure is reported. The single-crystal X-ray study reveals a dimeric structure with a distorted square planar coordination geometry around each copper atom, with an ONO-donor ligand and µ2-oxo group located between the two copper atoms. The secondary coordination sphere of Cu(II) is six-coordinate, with a NO3 − ion and methanol solvent molecule making weak interactions. Supramolecular interactions involving the adjacent complexes were investigated. The complex [Cu(HL)]2(CH3OH)2(NO3)2 was also characterized by physicochemical and spectroscopic methods. The biological activity of the free semicarbazone and its Cu(II) complex were evaluated by cytotoxicity assays against human cancer cell lines.

Graphical abstract

A dimeric stable complex between copper(II) and semicarbazone ligand has been synthesized, and the crystal structure has been studied. Spectroscopy experiments and cytotoxicity assays against human cancer cell lines were performed.

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Acknowledgements

We gratefully acknowledge the financial support of FINEP/CTINFRA, CNPq, CAPES, FAPDF and FUNCAP.

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Authors and Affiliations

  1. Laboratory of Inorganic Synthesis and Crystallography, University of Brasilia (IQ-UnB), Campus Universitário Darcy Ribeiro, P.O. Box 4478, Brasília, DF, CEP 70904970, Brazil

    Claudia C. Gatto, Patrícia M. Miguel, Carolane M. Almeida & Pedro H. O. Santiago

  2. Laboratory of Experimental Oncology, Center for Drug Research and Development, Faculty of Medicine, University of Ceará, Fortaleza, CE, CEP 60430275, Brazil

    Carlos R. K. Paier & Claudia Pessoa

  3. Oswaldo Cruz Foundation – Ceará (FIOCRUZ), Fortaleza, CE, CEP 60180900, Brazil

    Claudia Pessoa

Authors
  1. Claudia C. Gatto
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  2. Patrícia M. Miguel
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  3. Carolane M. Almeida
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  4. Pedro H. O. Santiago
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  5. Carlos R. K. Paier
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Correspondence to Claudia C. Gatto.

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Gatto, C.C., Miguel, P.M., Almeida, C.M. et al. A copper(II) complex of a semicarbazone: crystal structure, spectroscopic analysis and cytotoxicity against human cancer cell lines. Transit Met Chem 42, 503–508 (2017). https://doi.org/10.1007/s11243-017-0154-8

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  • DOI: https://doi.org/10.1007/s11243-017-0154-8

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