Abstract.
A full range of gold compounds is currently being investigated for their potential as anti-tumor agents. Gold(I) compounds related to the anti-arthritic drug \({\rm Auranofin}^\circledR\) continue to attract attention, especially those carrying biologically active molecules with anti-tumor activity in their own right. Tetrahedrally coordinated gold(I) compounds, that possibly target mitochondria, are under development with a particular focus upon moderating their hydrophilicity. A resurgence of interest in square-planar gold(III) compounds has occurred in the last decade. A wide variety of species: mono- and di-nuclear, neutral and charged, coordination and organometallic, etc. are being developed. Supporting many investigations are studies of mechanistic aspects of gold compounds but a clear understanding of the mechanism of action of these compounds has yet to be delineated.
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Received 4 July 2007; accepted 10 September 2007
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Tiekink, E.R.T. Anti-cancer potential of gold complexes. Inflammopharmacol 16, 138–142 (2008). https://doi.org/10.1007/s10787-007-0018-5
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DOI: https://doi.org/10.1007/s10787-007-0018-5