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Chemistry and antioxidant properties of titanium(IV) complexes

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Abstract

The synthesis of titanium(IV) complexes with biologically active hydrazide ligands has been carried out. The complexes were characterized by spectroscopic methods (IR, 1H NMR and 13C NMR), elemental analysis and conductivity studies. These studies suggest bidentate coordination of the ligands through carbonyl oxygen and primary amine nitrogen, resulting in octahedral geometries. Hydrazides with pyridyl substituents displayed 1:2 metal-to-ligand ratio, and hydrazides with imino substituents exhibited 1:3 metal-to-ligand ratio resulting in an outer sphere complex. The remaining complexes displayed inner sphere coordination with 1:1 metal-to-ligand ratio. These complexes exhibit varying degrees of radical scavenging properties against DPPH, superoxide and nitric oxide free radicals. The free ligands showed inhibition against DPPH but were inactive against superoxide and nitric oxide free radicals. The structure–activity relationships of the complexes are discussed.

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Acknowledgments

Authors are thankful to the Higher Education Commission of Pakistan for financial support (‘The National Research Grants Program for Universities,’ Grant No. 1862/R&D/10).

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Authors and Affiliations

  1. Department of Chemistry, University of Karachi, Karachi, 75270, Pakistan

    Zara Shaikh, Uzma Ashiq, Rifat Ara Jamal, Bushra Shamshad & Sadaf Sultan

  2. Department of Chemistry and Biochemistry, St. Cloud State University, St. Cloud, MN, 56304, USA

    Mohammad Mahroof-Tahir

  3. Department of Chemistry and Earth Sciences, Qatar University, Doha, Qatar

    Mohammad Mahroof-Tahir

Authors
  1. Zara Shaikh
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  2. Uzma Ashiq
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  3. Rifat Ara Jamal
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  4. Mohammad Mahroof-Tahir
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  5. Bushra Shamshad
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Correspondence to Mohammad Mahroof-Tahir.

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Shaikh, Z., Ashiq, U., Jamal, R.A. et al. Chemistry and antioxidant properties of titanium(IV) complexes. Transition Met Chem 40, 665–671 (2015). https://doi.org/10.1007/s11243-015-9960-z

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  • DOI: https://doi.org/10.1007/s11243-015-9960-z

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