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Meta-analyses of four eosinophil related gene variants in coronary heart disease

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Abstract

The goal of our study is to assess the contribution of four eosinophil related gene variants (rs12619285, rs1420101, rs3184504 and rs4143832) to the risk of coronary heart disease (CHD). We conducted four meta-analyses of studies examining the association between four eosinophil related gene variants and the risk of CHD. A systematic search was conducted using MEDLINE, EMBASE, Web of Science and China National Knowledge Infrastructure (CNKI), Wanfang Chinese Periodical. A case–control study was conducted between 162 CHD cases and 119 non-CHD controls to explore their contribution to CHD. For rs3184504 of SH2B3 gene, the meta-analysis was performed among 19 study stages among 94,555 participants. Significant association between rs3184504 and CHD risk was observed in European and South Asian populations (OR = 1.13, 95 % CI = 1.10–1.16, p < 0.0001, fixed-effect method). For the other SNPs (rs12619285, rs1420101, and rs4143832), we combined our case–control data with the previous studies and found no association of them with the risk of CHD. No significant contribution of the four genetic variants to CHD was observed in Han Chinese (p > 0.05). In conclusion, our results supported a significant association between rs3184504 of SH2B3 gene and the risk of CHD in Europeans and South Asians, although we were unable to observe association between the four variants and the risk of CHD in Han Chinese.

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Abbreviations

SNP:

Single nucleotide polymorphism

CAC:

Coronary artery calcification

CHD:

Coronary heart disease

MI:

Myocardial infarction

HWE:

Hardy–Weinberg equilibrium

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Acknowledgments

The research was supported by the grants from: National Natural Science Foundation of China (31100919 and 30772155), Zhejiang Provincial Program for the Cultivation of High level Innovative Health Talents, Natural Science Foundation of Zhejiang Province (Y206608), K.C. Wong Magna Fund in Ningbo University, and Youth and Doctor Foundation of Ningbo (2005A610016). The authors gratefully acknowledge the support of K.C. Wong Education Foundation, Hong Kong.

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo, 315041, Zhejiang, China

    Jiangfang Lian, Xi Yang, Weifeng Xu, Xiaoyan Huang & Jianqing Zhou

  2. The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, 315211, Zhejiang, China

    Yi Huang, Limin Xu, Yanping Le, Meng Ye & Shiwei Duan

  3. Department of Medicine, University of Chicago, Chicago, IL, 60637, USA

    R. Stephanie Huang

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  1. Jiangfang Lian
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Correspondence to Jianqing Zhou or Shiwei Duan.

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JL and YH are co-first authors of this work.

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Lian, J., Huang, Y., Huang, R.S. et al. Meta-analyses of four eosinophil related gene variants in coronary heart disease. J Thromb Thrombolysis 36, 394–401 (2013). https://doi.org/10.1007/s11239-012-0862-z

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