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Livedoid vasculopathy in a patient with lupus anticoagulant and MTHFR mutation: treatment with low-molecular-weight heparin

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Abstract

Livedoid vasculopathy is characterized by painful purpuric lesions on the extremities which frequently ulcerate and heal with atrophic scarring. For many years, livedoid vasculopathy has been considered to be a primary vasculitic process. However, there has been evidence considering livedoid vasculopathy as an occlusive vasculopathy due to a hypercoagulable state. We present the case of livedoid vasculopathy in a 21-year-old female who had been suffering of painful lower extremity lesions of 3 years duration. The patient was found to be lupus anticoagulant positive and homozygous for methylenetetrahydrofolate reductase C677T mutation. The patient was successfully treated with low-molecular-weight heparin.

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Conflict of interest

The authors state that they have no conflicts of interest to declare.

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Authors and Affiliations

  1. Hematology-Oncology Division, Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El-Solh, Beirut, 1107 2020, Lebanon

    Jihane Abou Rahal, Zaher K. Otrock & Ali T. Taher

  2. Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon

    Rim S. Ishak & Abdul-Ghani Kibbi

Authors
  1. Jihane Abou Rahal
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  2. Rim S. Ishak
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  3. Zaher K. Otrock
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  4. Abdul-Ghani Kibbi
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  5. Ali T. Taher
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Corresponding author

Correspondence to Ali T. Taher.

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Abou Rahal, J., Ishak, R.S., Otrock, Z.K. et al. Livedoid vasculopathy in a patient with lupus anticoagulant and MTHFR mutation: treatment with low-molecular-weight heparin. J Thromb Thrombolysis 34, 541–544 (2012). https://doi.org/10.1007/s11239-012-0743-5

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  • DOI: https://doi.org/10.1007/s11239-012-0743-5

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