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Livedoid vasculopathy associated with combined prothrombin G20210A and factor V (Leiden) heterozygosity and MTHFR C677T homozygosity

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Abstract

Livedoid vasculopathy (LV) is an occlusive thrombotic disease of lower extremities. A 34-year-old woman presented with 4-year history of recurrent necrotic and painful lesions with violaceous and purpuric border on both legs. Initial treatment with hydroxychloroquine, dapsone and prednisone were unsuccessful. Skin biopsy showed inflammatory infiltrate with epidermal necrosis. Prothrombin G20210A and factor V-Leiden heterozygosity, and MTHFR C677T homozygosity with hyperhomocysteinemia were confirmed. LV diagnosis was made; acetylsalicylic acid, folic acid, vitamin B12, and prednisone treatement resulted in complete healing. This is the first report on coexistence of prothrombin G20210A, factor V-Leiden, and homozygous MTHFR C677T with hyperhomocysteinemia in LV.

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Authors and Affiliations

  1. Department of Laboratory Medicine, St. Georges University Hospital, Beirut, Lebanon

    Noha A. Irani-Hakime & Isabelle Jureidini

  2. Department of Dermatology, St. Georges University Hospital, Beirut, Lebanon

    Farid Stephan

  3. Department of Vascular Surgery, St. Georges University Hospital, Beirut, Lebanon

    Raghid Kreidy

  4. Department of Medical Biochemistry, Arabian Gulf University, P.O. Box 22979, Manama, Bahrain

    Wassim Y. Almawi

Authors
  1. Noha A. Irani-Hakime
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  2. Farid Stephan
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  3. Raghid Kreidy
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  4. Isabelle Jureidini
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  5. Wassim Y. Almawi
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Correspondence to Wassim Y. Almawi.

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Irani-Hakime, N.A., Stephan, F., Kreidy, R. et al. Livedoid vasculopathy associated with combined prothrombin G20210A and factor V (Leiden) heterozygosity and MTHFR C677T homozygosity. J Thromb Thrombolysis 26, 31–34 (2008). https://doi.org/10.1007/s11239-008-0214-1

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  • DOI: https://doi.org/10.1007/s11239-008-0214-1

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