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Synthesis, crystal structure, and DNA-binding studies of a one-dimensional copper(II) polymer bridged both by oxamidate and thiocyanato ligands

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Abstract

A new one-dimensional copper(II) polymer, [Cu4(dmapox)2(SCN)4(CH3OH)2] n , where dmapox is the dianion of N,N′-bis[3-(dimethylamino)propyl]oxamide, was synthesized and characterized by elemental analysis, conductivity measurement, IR, and electronic spectral studies. The crystal structure of the copper(II) complex has been determined by X-ray single-crystal diffraction. The complex crystallizes in triclinic, space group P − 1 and exhibits infinite one-dimensional copper(II) polymeric chain bridged both by bis-tridentate μ-trans-dmapox and μ-1,3-thiocyanato ligand. The environment around the copper(II) atom can be described as distorted square-pyramid. The Cu···Cu separations through the oxamidate and thiocyanato bridges are 5.246(2) Å (Cu1–Cu1i), 5.2649(14) Å (Cu2–Cu2ii), and 5.8169(15) Å (Cu1–Cu2), respectively. The interaction of the copper(II) complex with herring sperm DNA (HS-DNA) has been investigated by using absorption and emission spectral and electrochemical techniques and viscometry. The results reveal that the copper(II) complex may interact with DNA in the mode of groove binding with the intrinsic binding constant of 2.56 × 105 M−1.

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Acknowledgments

This project was supported by the Foundation of Qingdao City (No. 06-2-2-11-jch), the National Natural Science Foundation of China (No. 30672515), the Ph.D. Program Foundation of Ministry of Education of China, and the National Undergraduate Innovative Test Program of China.

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Authors and Affiliations

  1. Marine Drug & Food Institute Ocean University of China, Qingdao, Shandong, 266003, People’s Republic of China

    Yan-Tuan Li, Zhi-Qiang Liu & Xiao-Wen Li

  2. Key Laboratory Marine Drug, Chinese Ministry of Education, Ocean University of China, Qingdao, People’s Republic of China

    Zhi-Yong Wu & Man Jiang

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  1. Yan-Tuan Li
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Correspondence to Yan-Tuan Li.

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Li, YT., Liu, ZQ., Wu, ZY. et al. Synthesis, crystal structure, and DNA-binding studies of a one-dimensional copper(II) polymer bridged both by oxamidate and thiocyanato ligands. Struct Chem 19, 819–826 (2008). https://doi.org/10.1007/s11224-008-9371-2

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