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Polymorphism of Alcohol Dehydrogenase Gene ADH1B in Eastern Slavic and Iranian-Speaking Populations

  • Human Genetics
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Abstract

Frequencies of alleles and genotypes for alcohol dehydrogenase gene ADH1B (arg47his polymorphism), associated with alcohol tolerance/sensitivity, were determined. It was demonstrated that the frequency of allele ADH1B*47his, corresponding to atypical alcohol dehydrogenase variant in Russians, Ukrainians, Iranians, and mountain-dwellers of the Pamirs constituted 3, 7, 24, and 22%, respectively. The frequencies established were consistent with the allele frequency distribution pattern among the populations of Eurasia. Russians and Ukrainians were indistinguishable from other European populations relative to the frequency of allele ADH1B*47his, and consequently, relative to specific features of ethanol metabolic pathways. The data obtained provide refinement of the geographic pattern of ADH1B*47his frequency distribution in Eurasia.

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Authors and Affiliations

  1. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia

    S. A. Borinskaya, F. Gasemianrodsari, N. R. Kalyina, M. V. Sokolova & N. K. Yankovsky

  2. Faculty of Biology, Department of Genetics, Moscow State University, Moscow, 119899, Russia

    M. V. Sokolova

Authors
  1. S. A. Borinskaya
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  2. F. Gasemianrodsari
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  3. N. R. Kalyina
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  4. M. V. Sokolova
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  5. N. K. Yankovsky
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__________

Translated from Genetika, Vol. 41, No. 11, 2005, pp. 1563–1566.

Original Russian Text Copyright © 2005 by Borinskaya, Gasemianrodsari, Kalyina, Sokolova, Yankovsky.

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Borinskaya, S.A., Gasemianrodsari, F., Kalyina, N.R. et al. Polymorphism of Alcohol Dehydrogenase Gene ADH1B in Eastern Slavic and Iranian-Speaking Populations. Russ J Genet 41, 1291–1294 (2005). https://doi.org/10.1007/s11177-005-0231-5

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  • DOI: https://doi.org/10.1007/s11177-005-0231-5

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