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Ferrocene-modified amino acids: synthesis and in vivo bioeffects on hippocampus

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Abstract

A method for the ferrocene modification of amino acids of natural and synthetic origin has been developed. In the in vivo studies, the hippocampal electrical activity under the action of ferrocenyl(phenylpyrazolyl)glycine (1) was assessed. A meaningful rise (up to 25% compared to the control) in the response amplitudes of the focal potentials of the hippocampal region СА1 after intraperitoneal administration of compound 1 at the dose of 2.0 mg kg–1 was established

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    А. N. Rodionov, L. V. Snegur & А. А. Simenel

  2. Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, 5А ul. Butlerova, 117485, Moscow, Russian Federation

    Yu. V. Dobryakova & V. А. Markevich

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  1. А. N. Rodionov
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  2. L. V. Snegur
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  4. Yu. V. Dobryakova
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Correspondence to L. V. Snegur.

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Based on the materials of the International Conference "Organometallic and Coordination Chemistry: Achievements and Challenges" (VI Razuvaev Lecture) (September 18–23, 2015, Nizhny Novgorod).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 0136—0142, January, 2017.

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Rodionov, А.N., Snegur, L.V., Simenel, А.А. et al. Ferrocene-modified amino acids: synthesis and in vivo bioeffects on hippocampus. Russ Chem Bull 66, 136–142 (2017). https://doi.org/10.1007/s11172-017-1711-1

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  • DOI: https://doi.org/10.1007/s11172-017-1711-1

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