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Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase

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Abstract

A series of adamantyl-containing 1,3-disubstituted diureas and thioureas containing different spacers between the ureylene group and the adamantyl substituent has been synthesized, their inhibitory activity against mammalian and human soluble epoxide hydrolase (sEH, E.C. 3.3.2.10) has been examined. The compounds synthesized were found to exhibit high inhibitory activity on the 0.4–2.8 nmol L−1 level. The dependence between the inhibitor structure and its activity was established

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Authors and Affiliations

  1. Volzhsky Polytechnic Institute (branch) of the Volgograd State Technical University, 42a ul. Engel´sa, 404130, Volzhsky, Volgograd Region, Russian Federation

    G. M. Butov, V. V. Burmistrov, D. V. Danilov & D. A. Pitushkin

  2. Department of Entomology and UCD Cancer Center, University of California Davis, One shields avenue, Davis, California, 95615, USA

    C. Morisseau & B. D. Hammock

Authors
  1. G. M. Butov
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  2. V. V. Burmistrov
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  3. D. V. Danilov
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  4. D. A. Pitushkin
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  5. C. Morisseau
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  6. B. D. Hammock
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Corresponding author

Correspondence to G. M. Butov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1569–1575, July, 2015.

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Butov, G.M., Burmistrov, V.V., Danilov, D.V. et al. Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase. Russ Chem Bull 64, 1569–1575 (2015). https://doi.org/10.1007/s11172-015-1043-y

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  • DOI: https://doi.org/10.1007/s11172-015-1043-y

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