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Synthesis of tetrazolodiazepines by a five-centered four-component azide Ugi reaction. Scope and limitations

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Abstract

Tetrazolo[1,5-a][1,4]benzodiazepines were obtained by an efficient azide five-centered four-component Ugi reaction, which used ketones, sodium azide, ammonium chloride, and the corresponding isonitrile. Scope and limitations of this multi-component reaction were considered.

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Authors and Affiliations

  1. A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 29 Leninsky prosp., 119991, Moscow, Russian Federation

    R. S. Borisov

  2. N. N. Blokhin Russian Cancer Scientific Center, Russian Academy of Medical Sciences, 24 Kashirskoe shosse, 115478, Moscow, Russian Federation

    A. I. Polyakov & L. A. Medvedeva

  3. Peoples’ Frendship University of Russia, 6 ul. Miklukho-Maklaya, 117198, Moscow, Russian Federation

    N. I. Guranova & L. G. Voskressensky

Authors
  1. R. S. Borisov
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  2. A. I. Polyakov
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  3. L. A. Medvedeva
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  4. N. I. Guranova
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  5. L. G. Voskressensky
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Corresponding author

Correspondence to L. G. Voskressensky.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1592—1598, August, 2012.

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Borisov, R.S., Polyakov, A.I., Medvedeva, L.A. et al. Synthesis of tetrazolodiazepines by a five-centered four-component azide Ugi reaction. Scope and limitations. Russ Chem Bull 61, 1609–1615 (2012). https://doi.org/10.1007/s11172-012-0214-3

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  • DOI: https://doi.org/10.1007/s11172-012-0214-3

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