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A green and one-pot synthesis of 6-amino-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile derivatives using CoCeO2 nanoparticles as an efficient, reusable and heterogeneous catalyst

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Abstract

In the present study, a novel, facile and environmentally benign protocol for the synthesis of pharmaceutically active 6-amino-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile derivatives using CoCeO2 (nanoparticles) NPs as an efficient, reusable and heterogeneous catalyst in aqueous medium is described. The CoCeO2 NPs were successfully synthesised using a simple co-precipitation method and confirmed using XRD, FESEM and HRTEM techniques. The high yields of the product, short reaction time, use of non-toxic materials, simple workup and reusability of the catalyst without loss of activity are the superior advantages of the present protocol.

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Authors and Affiliations

  1. Department of Chemistry, Changu Kana Thakur Arts, Commerce and Science College, New Panvel (Autonomous), Mumbai, 410206, India

    Shaheen A. Shaikh, Vishal S. Kamble, Rohan K. Zemase, Sanjay K. Patil & Balasaheb D. Aghav

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  1. Shaheen A. Shaikh
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  2. Vishal S. Kamble
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Contributions

SAS: Conceptualization, Methodology, Software, Writing—Original Draft and Investigation. VSK: Visualization, Software, Resources and Data Curation. RKZ: Methodology and Resources. SKP: Project administration, Methodology and Writing—Review. BDA: Conceptualization, Supervision, Formal analysis, Writing—Review and Editing, Resources and Software

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Correspondence to Balasaheb D. Aghav.

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Shaikh, S.A., Kamble, V.S., Zemase, R.K. et al. A green and one-pot synthesis of 6-amino-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile derivatives using CoCeO2 nanoparticles as an efficient, reusable and heterogeneous catalyst. Res Chem Intermed 49, 5255–5272 (2023). https://doi.org/10.1007/s11164-023-05156-7

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