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New biologically active mixed-ligand Co(II) and Ni(II) complexes of enrofloxacin

Synthesis, spectral study and thermal behaviour

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Abstract

New mixed-ligand Co(II) and Ni(II) complexes with enrofloxacin and 1,10-phenanthroline/8-hydroxyquinoline have been synthesized. The metal complexes have been characterized by elemental analyses, molar conductance, FT-IR, solid reflectance, magnetic moment, thermal analyses, X-ray powder diffraction (XRD) and SEM analysis. Conductance measurements indicate that all the complexes are non-electrolytes. Spectral IR data showed that the deprotonated enrofloxacin is bidentately bound to the metal ion through the pyridone oxygen and the carboxylated oxygen; 1,10-phenanthroline acts as neutral bidentate ligand coordinated through two nitrogen donor atoms, and the deprotonated 8-hydroxyquinoline is coordinated through nitrogen and oxygen donor atoms. The geometry of the complexes was elucidated with solid reflectance UV and magnetic moments. Thermal analysis recorded that TG/DTG/DSC experiments revealed the thermal stability of metal complexes and confirmed their compositions suggested by the analytical data. In addition to experimental data, a molecular modelling study has been performed to establish the optimized geometries of metal complexes. The XRD analysis of powders evidences the nanocrystalline nature of all complexes. The results are in agreement with molecular modelling data. SEM images revealed highly agglomerated particles with irregular shape with sizes in the micrometre range. The ligand and their metal complexes were screened for their antimicrobial activity against Escherichia coli 25922, Staphylococcus aureus 25923, Pseudomonas aeruginosa 27853 and Candida albicans 10231. The metal complexes were also investigated for their cytotoxicity using an in vitro assay.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, University of Craiova, 13 AI Cuza Street, 200585, Craiova, Romania

    Aurora Reiss, Nicoleta Cioatera, Anca Ganescu, Irina Dabuleanu & C. I. Spinu

  2. Department of Microbiology, Faculty of Biology, University of Bucharest, 1-4 Aleea Portocalelor Street, 60101, Bucharest, Romania

    Mariana Carmen Chifiriuc

  3. “Ilie Murgulescu” Institute of Physical Chemistry of the Romanian Academy, 202 Spl. Independentei, 060021, Bucharest, Romania

    G. Munteanu

  4. “I.Cantacuzino” National Institute of Research, 103 Spl. Independentei, Sector 5, 050096, Bucharest, Romania

    G. Avram

  5. Department of Physics, Faculty of Sciences, University of Craiova, 13 AI Cuza Street, 200585, Craiova, Romania

    P. Rotaru

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  1. Aurora Reiss
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  2. Nicoleta Cioatera
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Reiss, A., Cioatera, N., Chifiriuc, M.C. et al. New biologically active mixed-ligand Co(II) and Ni(II) complexes of enrofloxacin. J Therm Anal Calorim 134, 527–541 (2018). https://doi.org/10.1007/s10973-018-6994-4

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