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Microwave-irradiated one-pot synthesis of quinoline derivatives catalyzed by triethylamine

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Abstract

An efficient and swift microwave (MW)-mediated procedure for synthesis of 11 quinoline derivatives has been designed based on reaction between aromatic aldehydes, malononitrile, 5,5-dimethylcyclohexane-1,3-dione, and ammonium acetate at room temperature in ethanol solvent. The main advantages of this method are operational simplicity, excellent yield (92–98 %), use of green solvent, short reaction time (<15 min), mild reaction condition, and no byproducts.

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Acknowledgements

The authors are grateful to the National Research Foundation (NRF) of South Africa, and University of KwaZulu-Natal, Durban, for financial support and research facilities.

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Authors and Affiliations

  1. School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban, 4000, South Africa

    Sanele Moloi, Suresh Maddila & Sreekantha B. Jonnalagadda

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  1. Sanele Moloi
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  2. Suresh Maddila
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  3. Sreekantha B. Jonnalagadda
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Correspondence to Sreekantha B. Jonnalagadda.

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Moloi, S., Maddila, S. & Jonnalagadda, S.B. Microwave-irradiated one-pot synthesis of quinoline derivatives catalyzed by triethylamine. Res Chem Intermed 43, 6233–6243 (2017). https://doi.org/10.1007/s11164-017-2986-4

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