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Citric acid, a green catalyst for the one-pot, multi-component synthesis of highly substituted piperidines

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Abstract

Citric acid has been used as a green and efficient catalyst for one-pot, multi-component synthesis of highly substituted piperidines by condensation of aromatic aldehydes, aromatic amines, and β-ketoesters in MeOH at ambient temperature. This method has several advantages including use of a nonhazardous and inexpensive catalyst, easy work-up, clean reaction conditions, and high yields.

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Authors and Affiliations

  1. Department of Chemistry, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran

    Zahra Madanifar, Malek-Taher Maghsoodlou, Mehrnoosh Kangani & Nourallah Hazeri

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  1. Zahra Madanifar
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  2. Malek-Taher Maghsoodlou
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  3. Mehrnoosh Kangani
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  4. Nourallah Hazeri
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Correspondence to Malek-Taher Maghsoodlou.

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Madanifar, Z., Maghsoodlou, MT., Kangani, M. et al. Citric acid, a green catalyst for the one-pot, multi-component synthesis of highly substituted piperidines. Res Chem Intermed 41, 9863–9869 (2015). https://doi.org/10.1007/s11164-015-1993-6

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