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Solvent-free efficient one-pot synthesis of Biginelli and Hantzsch compounds catalyzed by potassium phthalimide as a green and reusable organocatalyst

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Abstract

The usage of potassium phthalimide (PPI) for the simple and green one-step multicomponent synthesis of Hantzsch 1,4-dihydropyridines, polyhydroquinolines, 3,4-dihydropyrimidin-2(1H)-ones/thiones, and octahydroquinazolinones under solventless conditions at 120 °C is reported. The method is operationally simple, environmentally benign, and has relatively high yields. The other merits of this method include efficient, clean, green, and catalyst reusability.

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Acknowledgment

The authors are grateful to the Research Council of Damghan University.

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  1. School of Chemistry, Damghan University, 36715-364, Damghan, Iran

    Hamzeh Kiyani & Maryam Ghiasi

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  1. Hamzeh Kiyani
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  2. Maryam Ghiasi
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Correspondence to Hamzeh Kiyani.

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Kiyani, H., Ghiasi, M. Solvent-free efficient one-pot synthesis of Biginelli and Hantzsch compounds catalyzed by potassium phthalimide as a green and reusable organocatalyst. Res Chem Intermed 41, 5177–5203 (2015). https://doi.org/10.1007/s11164-014-1621-x

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