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Microporous zeolite catalyst system: an eco-approach for regioselective synthesis of pyrimidobenzimidazoles

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Abstract

Microporous zeolite, having well-defined pore sizes, was found to be most efficient catalyst for regioselective synthesis of pyrimidobenzimidazoles. Different kinds of zeolites were studied as supported microporous material and showed quite different catalytic activities due to high acidity, excellent textural parametersm and cage-type 3D porous structure under microwaves, and hold great promise due to excellent reusability properties. The structure of the products was confirmed by spectral and X-ray studies. Furthermore, the reaction was performed over a considerably shorter reaction time and generated significantly higher yields under microwaves than by traditional methods.

Graphical Abstract

Ordered microporous materials with well-defined pore sizes are proven as active green catalysts for regioselective synthesis of pyrimidobenzimidazoles. Five kinds of zeolites were studied and showed quite different catalytic activities due to their wide acid sites distributions and various pore structures. The structure of the product was confirmed by NOE and X-ray studies.

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Acknowledgments

K.A. acknowledges the D.S.T. (SR/FT/CS-69/2013), New Delhi, India and the University of Delhi, Delhi, India for financial support.

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  1. Department of Chemistry, University of Delhi, Delhi, 110007, India

    Kapil Arya & Ravi Tomar

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  1. Kapil Arya
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  2. Ravi Tomar
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Correspondence to Kapil Arya.

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Arya, K., Tomar, R. Microporous zeolite catalyst system: an eco-approach for regioselective synthesis of pyrimidobenzimidazoles. Res Chem Intermed 41, 3389–3400 (2015). https://doi.org/10.1007/s11164-013-1441-4

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