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(±)-Camphor-10-sulfonic acid catalyzed atom efficient and green synthesis of triazolo[1,2-a]indazole-triones and spiro triazolo[1,2-a]indazole-tetraones

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Abstract

(±)-Camphor-10-sulfonic acid is used for the synthesis of triazolo[1,2-a]indazole-triones and spiro triazolo[1,2-a]indazole-tetraones by condensation reaction of dimedone, urazole and aromatic aldehydes or isatin. The noteworthy aspects of this new method are high yields, high atom efficiency, use of non-toxic solvent, mild conditions, simple workup and synthesis of complex molecules using an eco-friendly, inexpensive catalyst.

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Acknowledgments

We are grateful to Department of Chemistry, Shivaji University, Kolhapur for providing spectral analysis.

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Authors and Affiliations

  1. Hetrocyclic Laboratory, Department of Chemistry, Shivaji University, Kolhapur, 416004, India

    Dattatray R. Chandam, Abhijeet G. Mulik, Prasad P. Patil, Suryabala D. Jagdale, Dayanand R. Patil & Madhukar B. Deshmukh

  2. Department of Agrochemicals and Pest Management, Shivaji University, Kolhapur, 416004, India

    Prasad P. Patil & Madhukar B. Deshmukh

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  1. Dattatray R. Chandam
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  2. Abhijeet G. Mulik
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  3. Prasad P. Patil
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  4. Suryabala D. Jagdale
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  5. Dayanand R. Patil
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  6. Madhukar B. Deshmukh
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Correspondence to Dattatray R. Chandam.

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Chandam, D.R., Mulik, A.G., Patil, P.P. et al. (±)-Camphor-10-sulfonic acid catalyzed atom efficient and green synthesis of triazolo[1,2-a]indazole-triones and spiro triazolo[1,2-a]indazole-tetraones. Res Chem Intermed 41, 761–771 (2015). https://doi.org/10.1007/s11164-013-1226-9

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