Skip to main content

Advertisement

SpringerLink
Log in

EQ-5D in Central and Eastern Europe: 2000–2015

  • Review
  • Published:
Quality of Life Research Aims and scope Submit manuscript

Abstract

Objective

Cost per quality-adjusted life year data are required for reimbursement decisions in many Central and Eastern European (CEE) countries. EQ-5D is by far the most commonly used instrument to generate utility values in CEE. This study aims to systematically review the literature on EQ-5D from eight CEE countries.

Methods

An electronic database search was performed up to 1 July 2015 to identify original EQ-5D studies from the countries of interest. We analysed the use of EQ-5D with respect to clinical areas, methodological rigor, population norms and value sets.

Results

We identified 143 studies providing 152 country-specific results with a total sample size of 81,619: Austria (n = 11), Bulgaria (n = 6), Czech Republic (n = 18), Hungary (n = 47), Poland (n = 51), Romania (n = 2), Slovakia (n = 3) and Slovenia (n = 14). Cardiovascular (21 %), neurologic (17 %), musculoskeletal (15 %) and endocrine, nutritional and metabolic diseases (13 %) were the most frequently studied clinical areas. Overall, 112 (78 %) of the studies reported EQ VAS results and 86 (60 %) EQ-5D index scores, of which 27 (31 %) did not specify the applied tariff. Hungary, Poland and Slovenia have population norms. Poland and Slovenia also have a national value set.

Conclusions

Increasing use of EQ-5D is observed throughout CEE. The spread of health technology assessment activities in countries seems to be reflected in the number of EQ-5D studies. However, improvement in informed use and methodological quality of reporting is needed. In jurisdictions where no national value set is available, in order to ensure comparability we recommend to apply the most frequently used UK tariff. Regional collaboration between CEE countries should be strengthened.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Gulacsi, L., Rotar, A. M., Niewada, M., Loblova, O., Rencz, F., Petrova, G., et al. (2014). Health technology assessment in Poland, the Czech Republic, Hungary, Romania and Bulgaria. The European Journal of Health Economics, 15(Suppl 1), S13–25.

    Article  PubMed  Google Scholar 

  2. Az Emberi Eroforrások Minisztériuma szakmai irányelve az egészség-gazdaságtani elemzések készítéséhez (hatályos: 2013.03.01-től) (2013). Egészségügyi Közlöny (3), 1314–1334.

  3. Vyhláška Ministerstva zdravotníctva Slovenskej republiky č. 343/2008 zo 14. augusta 2008 o podrobnostiach farmako-ekonomického rozboru lieku. http://www.health.gov.sk/Zdroje?/Sources/dokumenty/zdravotnicke_pomocky/Vyhlaska_343_2008_FE_rozbor_lieku.pdf. Accessed 31 Aug 2015.

  4. Agency for Health Technology Assessment. Guidelines for conducting Health Technology Assessment (HTA). Version 2.1. (2009). http://www.ispor.org/peguidelines/source/Poland_Guidelines-for-Conducting-HTA_English-Version.pdf. Accessed 4 Sept 2015.

  5. Gesundheit Österreich GmbH. Methodenhandbuch für Health Technology Assessment. Version 1.2012. Wissenschaftlicher Ergebnisbericht. (2012). http://www.goeg.at/cxdata/media/download/berichte/MHB_Vorabversion_2012.pdf. Accessed 14 Feb 2016.

  6. Ministry of Health, Romania. HTA Order 722/2013. http://www.ms.ro/documente/ORDIN%20HTA_772_1523.pdf. Accessed 11 Sept 2015.

  7. Assembly of the Health Insurance Institute of Slovenia. Rules on the Classification of Medicine on the List (Official Gazette of RS, no. 110/2010, dated 12/31/2010 no. 5779) 2010.

  8. Doležal, T. What is the role of HE in decision making process? Czech perspective perspective. ISPOR 12th Annual European Congress, 24–27 October 2009. http://www.ispor.org/congresses/paris1009/documents/CzechRepublicChapterSlides.pdf. Accessed 1 Sept 2015.

  9. Gulacsi, L., Rencz, F., Pentek, M., Brodszky, V., Lopert, R., Hever, N. V., et al. (2014). Transferability of results of cost utility analyses for biologicals in inflammatory conditions for Central and Eastern European countries. The European Journal of Health Economics, 15(Suppl 1), S27–34.

    Article  PubMed  Google Scholar 

  10. The Act on Reimbursement of Medicines, Foodstuffs Intended for Particular Nutritional Purposes and Medical Devices from 12th of May, 2011 (Journal of Laws, No. 122, item 696).

  11. Baji, P., Brodszky, V., Rencz, F., Boncz, I., Gulácsi, L., & Péntek, M. (2015). Health status of the Hungarian population between 2000–2010. Orvosi Hetilap, 156(50.), 2035–2044.

  12. Szende, A., Leidy, N. K., Ståhl, E., & Svensson, K. (2009). Estimating health utilities in patients with asthma and COPD: Evidence on the performance of EQ-5D and SF-6D. Quality of Life Research, 18(2), 267–272.

    Article  CAS  PubMed  Google Scholar 

  13. Yordanova, S., Petkova, V., Petrova, G., Dimitrov, M., Naseva, E., Dimitrova, M., et al. (2014). Comparison of health-related quality-of-life measurement instruments in diabetic patients. Biotechnology and Biotechnological Equipment, 28(4), 769–774.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Hever, N. V., Pentek, M., Ballo, A., Gulacsi, L., Baji, P., Brodszky, V., et al. (2015). Health related quality of life in patients with bladder cancer: a cross-sectional survey and validation study of the hungarian version of the bladder cancer index. Pathology & Oncology Research, 21(3), 619–627.

    Article  Google Scholar 

  15. Felder-Puig, R., Frey, E., Sonnleithner, G., Feeny, D., Gadner, H., Barr, R. D., et al. (2000). German cross-cultural adaptation of the Health Utilities Index and its application to a sample of childhood cancer survivors. European Journal of Pediatrics, 159(4), 283–288.

    Article  CAS  PubMed  Google Scholar 

  16. Rencz, F., Brodszky, V., Pentek, M., Bereczki, D., & Gulacsi, L. (2015). Health state utilities for migraine based on attack frequency: a time trade-off study. Neurological Sciences, 36(2), 197–202.

    Article  PubMed  Google Scholar 

  17. Obaidi, L. A., & Mahlich, J. (2015). A potential gender bias in assessing quality of life—a standard gamble experiment among university students. ClinicoEconomics and outcomes research, 7, 227–233.

    PubMed  PubMed Central  Google Scholar 

  18. Inotai, A., Rojkovich, B., Fulop, A., Jaszay, E., Agh, T., & Meszaros, A. (2012). Health-related quality of life and utility in patients receiving biological and non-biological treatments in rheumatoid arthritis. Rheumatology International, 32(4), 963–969.

    Article  PubMed  Google Scholar 

  19. Tillinger, W., Mittermaier, C., Lochs, H., & Moser, G. (1999). Health-related quality of life in patients with Crohn’s disease: influence of surgical operation–a prospective trial. Digestive Diseases and Sciences, 44(5), 932–938.

    Article  CAS  PubMed  Google Scholar 

  20. National Institute for Health and Care Excellence (NICE). Guide to the Methods of Technology Appraisal (2013). http://www.nice.org.uk/article/pmg9/resources/non-guidance-guide-to-the-methods-of-technology-appraisal-2013-pdf. Accessed 23 June 2015.

  21. Siegel, J. E., Torrance, G. W., Russell, L. B., Luce, B. R., Weinstein, M. C., & Gold, M. R. (1997). Guidelines for pharmacoeconomic studies. Recommendations from the panel on cost effectiveness in health and medicine. Panel on cost Effectiveness in Health and Medicine. Pharmacoeconomics, 11(2), 159–168.

    Article  CAS  PubMed  Google Scholar 

  22. Методологични указания за представяните документи за оценка на ефикасността, безопасността и фармакоикономическите показатели на лекарствени продукти при кандидатстване за включване в Позитивен лекарствен списък. (Приети на Заседание на НСЦРЛП – Протокол № 114/23.04.2015 г.) (2015).

  23. Coretti, S., Ruggeri, M., & McNamee, P. (2014). The minimum clinically important difference for EQ-5D index: a critical review. Expert Review of Pharmacoeconomics & Outcomes Research, 14(2), 221–233.

    Article  Google Scholar 

  24. Tordrup, D., Mossman, J., & Kanavos, P. (2014). Responsiveness of the EQ-5D to clinical change: is the patient experience adequately represented? International Journal of Technology Assessment in Health Care, 30(1), 10–19.

    Article  PubMed  Google Scholar 

  25. Payakachat, N., Ali, M. M., & Tilford, J. M. (2015). Can The EQ-5D Detect Meaningful Change? A Systematic Review. Pharmacoeconomics, 33(11), 1137–1154.

    PubMed  Google Scholar 

  26. Xie, F., Gaebel, K., Perampaladas, K., Doble, B., & Pullenayegum, E. (2014). Comparing EQ-5D valuation studies: a systematic review and methodological reporting checklist. Medical Decision Making, 34(1), 8–20.

    Article  PubMed  Google Scholar 

  27. Janssen, M. F., Lubetkin, E. I., Sekhobo, J. P., & Pickard, A. S. (2011). The use of the EQ-5D preference-based health status measure in adults with Type 2 diabetes mellitus. Diabetic Medicine, 28(4), 395–413.

    Article  CAS  PubMed  Google Scholar 

  28. Pickard, A. S., Wilke, C., Jung, E., Patel, S., Stavem, K., & Lee, T. A. (2008). Use of a preference-based measure of health (EQ-5D) in COPD and asthma. Respiratory Medicine, 102(4), 519–536.

    Article  PubMed  Google Scholar 

  29. Pickard, A. S., Wilke, C. T., Lin, H. W., & Lloyd, A. (2007). Health utilities using the EQ-5D in studies of cancer. Pharmacoeconomics, 25(5), 365–384.

    Article  PubMed  Google Scholar 

  30. Davis, S., & Wailoo, A. (2013). A review of the psychometric performance of the EQ-5D in people with urinary incontinence. Health and Quality of Life Outcomes, 11, 20.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Dyer, M. T., Goldsmith, K. A., Sharples, L. S., & Buxton, M. J. (2010). A review of health utilities using the EQ-5D in studies of cardiovascular disease. Health and Quality of Life Outcomes, 8, 13.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Hounsome, N., Orrell, M., & Edwards, R. T. (2011). EQ-5D as a quality of life measure in people with dementia and their carers: evidence and key issues. Value Health, 14(2), 390–399.

    Article  PubMed  Google Scholar 

  33. Moller, A. H., Erntoft, S., Vinding, G. R., & Jemec, G. B. (2015). A systematic literature review to compare quality of life in psoriasis with other chronic diseases using EQ-5D-derived utility values. Patient Related Outcome Measures, 6, 167–177.

    PubMed  PubMed Central  Google Scholar 

  34. Noyes, J., & Edwards, R. T. (2011). EQ-5D for the assessment of health-related quality of life and resource allocation in children: a systematic methodological review. Value Health, 14(8), 1117–1129.

    Article  CAS  PubMed  Google Scholar 

  35. Papaioannou, D., Brazier, J., & Parry, G. (2011). How valid and responsive are generic health status measures, such as EQ-5D and SF-36, in schizophrenia? A systematic review. Value Health, 14(6), 907–920.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Derrett, S., Black, J., & Herbison, G. P. (2009). Outcome after injury-a systematic literature search of studies using the EQ-5D. Journal of Trauma, 67(4), 883–890.

    Article  PubMed  Google Scholar 

  37. EuroQol Group. (1990). EuroQol–a new facility for the measurement of health-related quality of life. Health Policy, 16(3), 199–208.

    Article  Google Scholar 

  38. Brooks, R. (1996). EuroQol: the current state of play. Health Policy, 37(1), 53–72.

    Article  CAS  PubMed  Google Scholar 

  39. Herdman, M., Gudex, C., Lloyd, A., Janssen, M., Kind, P., Parkin, D., et al. (2011). Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Quality of Life Research, 20(10), 1727–1736.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Janssen, M. F., Pickard, A. S., Golicki, D., Gudex, C., Niewada, M., Scalone, L., et al. (2013). Measurement properties of the EQ-5D-5L compared to the EQ-5D-3L across eight patient groups: a multi-country study. Quality of Life Research, 22(7), 1717–1727.

    Article  CAS  PubMed  Google Scholar 

  41. Ravens-Sieberer, U., Wille, N., Badia, X., Bonsel, G., Burstrom, K., Cavrini, G., et al. (2010). Feasibility, reliability, and validity of the EQ-5D-Y: results from a multinational study. Quality of Life Research, 19(6), 887–897.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Wille, N., Badia, X., Bonsel, G., Burstrom, K., Cavrini, G., Devlin, N., et al. (2010). Development of the EQ-5D-Y: a child-friendly version of the EQ-5D. Quality of Life Research, 19(6), 875–886.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ, 339, b2535.

    Article  PubMed  PubMed Central  Google Scholar 

  44. International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10). (2015). http://apps.who.int/classifications/icd10/browse/2015/en. Accessed 4 Sept 2015.

  45. De Smedt, D., Clays, E., Doyle, F., Kotseva, K., Prugger, C., Pajak, A., et al. (2013). Validity and reliability of three commonly used quality of life measures in a large European population of coronary heart disease patients. International Journal of Cardiology, 167(5), 2294–2299.

    Article  PubMed  Google Scholar 

  46. De Smedt, D., Clays, E., Hofer, S., Oldridge, N., Kotseva, K., Maggioni, A. P., et al. (2016). Validity and reliability of the HeartQoL questionnaire in a large sample of stable coronary patients: The EUROASPIRE IV Study of the European Society of Cardiology. European Journal of Preventive Cardiology, 23(7), 714–721.

    Article  PubMed  Google Scholar 

  47. Barbist, M. T., Renn, D., Noisternig, B., Rumpold, G., & Hofer, S. (2008). How do medical students value health on the EQ-5D? Evaluation of hypothetical health states compared to the general population. Health and Quality of Life Outcomes, 6, 111.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Borgstrom, F., Lekander, I., Ivergard, M., Strom, O., Svedbom, A., Alekna, V., et al. (2013). The International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS)—Quality of life during the first 4 months after fracture. Osteoporosis International, 24(3), 811–823.

    Article  CAS  PubMed  Google Scholar 

  49. Cichocki, M., Quehenberger, V., Zeiler, M., Adamcik, T., Manousek, M., Stamm, T., et al. (2015). Effectiveness of a low-threshold physical activity intervention in residential aged care—results of a randomized controlled trial. Clinical Interventions in Aging, 10, 885–895.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Gamper, G., Willeit, M., Sterz, F., Herkner, H., Zoufaly, A., Hornik, K., et al. (2004). Life after death: posttraumatic stress disorder in survivors of cardiac arrest–prevalence, associated factors, and the influence of sedation and analgesia. Critical Care Medicine, 32(2), 378–383.

    Article  PubMed  Google Scholar 

  51. Ghosh, P., Djordjevic, M., Schistek, R., Baier, R., & Unger, F. (2003). Does gender affect outcome of cardiac surgery in octogenarians? Asian Cardiovascular and Thoracic Annals, 11(1), 28–32.

    Article  PubMed  Google Scholar 

  52. Hofer, S., Kullich, W., Graninger, U., Wonisch, M., Gassner, A., Klicpera, M., et al. (2009). Cardiac rehabilitation in Austria: long term health-related quality of life outcomes. Health and Quality of Life Outcomes, 7, 99.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Kobelt, G., Berg, J., Lindgren, P., Plesnilla, C., Baumhackl, U., Berger, T., et al. (2006). Costs and quality of life of multiple sclerosis in Austria. The European Journal of Health Economics, 7(Suppl 2), S14–23.

    Article  PubMed  Google Scholar 

  54. Prugger, M., & Berger, T. (2013). Assessing the long-term clinical benefit of prolonged-release fampridine tablets in a real-world setting: a review of 67 cases. Patient Related Outcome Measures, 4, 75–85.

    PubMed  PubMed Central  Google Scholar 

  55. Quehenberger, V., Cichocki, M., & Krajic, K. (2014). Sustainable effects of a low-threshold physical activity intervention on health-related quality of life in residential aged care. Clinical Interventions in Aging, 9, 1853–1864.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Winter, Y., Von Campenhausen, S., Gasser, J., Seppi, K., Reese, J. P., Pfeiffer, K. P., et al. (2010). Social and clinical determinants of quality of life in Parkinson’s disease in Austria: A cohort study. Journal of Neurology, 257(4), 638–645.

    Article  PubMed  Google Scholar 

  57. Ganzinger, U., Badelt, C., Vass, K., Strasser-Fuchs, S., Fazekas, F., Berger, T., et al. (2004). Krankheitskosten der multiplen Sklerose in Österreich. Der Nervenarzt, 75(10), 1000–1006.

    Article  CAS  PubMed  Google Scholar 

  58. Naseva, E., Bratovanova, S., Stoicheval, M., & Gardeva, M. (2015). Health related quality of life—A comparison of EQ-5D index calculation methods. General Medicine, 16(3), 3–8.

    Google Scholar 

  59. Vankova, D., Kerekovska, A., Kostadinova, T., & Todorova, L. (2015). Researching health-related quality of life at a community level: results from a population survey conducted in Burgas, Bulgaria. Health Promot Int. 2015 March 16 pii:dav016 [Epub ahead of print].

  60. Iskrov, G. G., Stefanov, R. S., Lopez-Bastida, J., Linertova, R., Oliva-Moreno, J., & Serrano-Aguilar, P. (2015). Economic burden and health-related quality of life of patients with cystic fibrosis in Bulgaria. Folia Medica (Plovdiv), 57(1), 56–64.

    Google Scholar 

  61. Abrahámová, J. (2007). Quality of life improvement in patients with bone metastases treated by clodronate. Praktický lékař, 87(11), 648–654.

    Google Scholar 

  62. Bulkova, V., Fiala, M., Havranek, S., Simek, J., Sknouril, L., Januska, J., et al. (2014). Improvement in quality of life after catheter ablation for paroxysmal versus long-standing persistent atrial fibrillation: a prospective study with 3-year follow-up. Journal of the American Heart Association, 3(4), e000881.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Fiala, M., Wichterle, D., Bulkova, V., Sknouril, L., Nevralova, R., Toman, O., et al. (2014). A prospective evaluation of haemodynamics, functional status, and quality of life after radiofrequency catheter ablation of long-standing persistent atrial fibrillation. Europace, 16(1), 15–25.

    Article  PubMed  Google Scholar 

  64. Haman, L., Dostalova, H., & Parizek, P. (2012). Catheter ablation for atrial fibrillation—Single center experience. Cor et Vasa, 54(6), e369–e374.

    Article  Google Scholar 

  65. Horak, P., Skacelova, M., Hejduk, K., Smrzova, A., & Pavelka, K. (2013). Abatacept and its use in the treatment of rheumatoid arthritis (RA) in the Czech Republic-data from the ATTRA registry. Clinical Rheumatology, 32(10), 1451–1458.

    Article  PubMed  Google Scholar 

  66. Špirudová, L., & Nol, J. (2014). Quality of life of patients after lung transplantation. Kontakt, 16(1), 12–20.

    Article  Google Scholar 

  67. Židková, A., Chytra, I., Šestáková, B., Kasal, E., & Týblová, I. (2012). Quality of life one year after discharge from ICU. Anaesthesiology & Intensive Medicine, 23(2), 75–81.

    Google Scholar 

  68. Kala, P., Tretina, M., Poloczek, M., Ondrasek, J., Malik, P., Pokorny, P., et al. (2013). Quality of life after transcatheter aortic valve implantation and surgical replacement in high-risk elderly patients. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia, 157(1), 75–80.

    Article  Google Scholar 

  69. Sauerland, S., Weiner, S., Hausler, E., Dolezalova, K., Angrisani, L., Noguera, C. M., et al. (2009). Validity of the Czech, German, Italian, and Spanish version of the Moorehead-Ardelt II questionnaire in patients with morbid obesity. Obesity Facts, 2(Suppl 1), 57–62.

    Article  PubMed  Google Scholar 

  70. Dolezal, T., Vocelka, M., & Klimes, J. (2012). Clinical effectiveness of 8% capsaicin dermal patch in neuropathic pain—Noninterventional real-life clinical study in Czech Republic. Bolest, 15(1), 28–32.

    Google Scholar 

  71. Otruba, P. (2015). Neuritogen and diabetic neuropathic pain. Bolest, 18(1), 29–35.

    Google Scholar 

  72. Slovacek, L., Slovackova, B., Blazek, M., & Jebavy, L. (2007). Quality of life in patients with multiple myeloma and malignant lymphoma undergoing autologous progenitor stem cell transplantation: The effect of selected psychosocial and health aspects on quality of life: A retrospective analysis. Reports of Practical Oncology and Radiotherapy, 12(2), 101–108.

    Article  Google Scholar 

  73. Slovacek, L., Slovackova, B., & Chovanec, V. (2007). The effect of femoral and popliteal percutaneous transluminal balloon angioplasty on patients’ quality of life. Sao Paulo Medical Journal, 125(4), 250–252.

    Article  PubMed  Google Scholar 

  74. Slovacek, L., Slovackova, B., Pavlik, V., & Slanska, I. (2009). Sibutramine - Its impact on health-related quality of life and depression among adult obese non-diabetic patients. Bratislava Medical Journal, 110(8), 496–499.

    CAS  PubMed  Google Scholar 

  75. Slovacek, L., Slovackova, B., Slanska, I., Petera, J., & Priester, P. (2010). Quality of life and depression among metastatic breast cancer patients. Medical Oncology, 27(3), 958–959.

    Article  PubMed  Google Scholar 

  76. Zavada, J., Uher, M., Jarkovsky, J., Vencovsky, J., & Pavelka, K. (2014). Assessment of utility score EQ-D and estimating the Cost-utility of the first year of treatment by TNF inhibitors in a cohort of patients with Rheumatoid Arthritis during-results from the Czech biologics registry ATTRA. Česká Revmatologie, 22(1), 10–16.

    Google Scholar 

  77. Balogh, O., Pentek, M., Gulacsi, L., Farkas, K., Jarai, Z., Landi, A., et al. (2013). Quality of life and burden of disease in peripheral arterial disease: a study among Hungarian patients. Orvosi Hetilap, 154(12), 464–470.

    Article  PubMed  Google Scholar 

  78. Brodszky, V., Péntek, M., Komoly, S., Bereczki, D., Embey-Isztin, D., Torzsa, P., et al. (2015). Quality of life of patients with non-diabetic peripheral neuropathic pain; results from a cross-sectional survey in general practices in Hungary. Ideggyogyaszati Szemle, 68(9–10), 325–330.

    Article  PubMed  Google Scholar 

  79. Deli, G., Balas, I., Doczi, T., Janszky, J., Karadi, K., Aschermann, Z., et al. (2015). Deep brain stimulation can preserve working status in Parkinson’s disease. Parkinsons Disease, 2015, 936865.

    Google Scholar 

  80. Minier, T., Pentek, M., Brodszky, V., Ecseki, A., Karpati, K., Polgar, A., et al. (2010). Cost-of-illness of patients with systemic sclerosis in a tertiary care centre. Rheumatology (Oxford), 49(10), 1920–1928.

    Article  Google Scholar 

  81. Péntek, M., Brodszky, V., Érsek, K., Jelics, N., Jermendy, G., Winkler, G., et al. (2009). Health status and quality of life of insulin treated diabetic adults—cross-sectional survey of 480 patients attending general practitioners and diabetology centres. Diabetologia Hungarica, 17(3), 249–260.

    Google Scholar 

  82. Pentek, M., Brodszky, V., Gulacsi, A. L., Hajdu, O., van Exel, J., Brouwer, W., et al. (2014). Subjective expectations regarding length and health-related quality of life in Hungary: results from an empirical investigation. Health Expectations, 17(5), 696–709.

    Article  PubMed  Google Scholar 

  83. Péntek, M., Herczegfalvi, Á., Molnár, M. J., Szőnyi, L., Kosztolányi, G., Pfliegler, G., et al. (2016). Disease burden of Duchenne muscular dystrophy patients and their caregivers. Ideggyogyaszati Szemle, 69(5–6), 183–193.

  84. Pentek, M., Kosztolanyi, G., Melegh, B., Halasz, A., Pogany, G., Baji, P., et al. (2014). Health related quality of life and disease burden of patients with cystic fibrosis and their caregivers: Results of the European BURQOL-RD survey in Hungary. Orvosi Hetilap, 155(42), 1673–1684.

    Article  PubMed  Google Scholar 

  85. Péntek, M., Licker-Fóris, E., Lovas, K., Kaló, Z., Tóth, M., Tulassay, Z., et al. (2003). Assessment of quality of life in postmenopausal women with osteoporosis—A comparative study on the Hungarian adaptations of EuroQoL and Nottingham Health Profile. Ca & Csont, 6(4), 158–163.

    Google Scholar 

  86. Rencz, F., Brodszky, V., Pentek, M., Balogh, O., Remenyik, E., Szegedi, A., et al. (2014). Disease burden of psoriasis associated with psoriatic arthritis in Hungary. Orvosi Hetilap, 155(48), 1913–1921.

    Article  PubMed  Google Scholar 

  87. Vokó, Z., Inotai, A., Horváth, C., Bors, K., Speer, G., & Kaló, Z. (2013). Quality of life in patients with osteoporosis in Hungary. Lege Artis Medicinae KID, 3(4), 35–41.

    Google Scholar 

  88. Agh, T., Inotai, A., & Meszaros, A. (2011). Factors associated with medication adherence in patients with chronic obstructive pulmonary disease. Respiration, 82(4), 328–334.

    Article  PubMed  Google Scholar 

  89. Bosnyak, E., Herceg, M., Pal, E., Aschermann, Z., Janszky, J., Kesmarki, I., et al. (2014). Are branded and generic extended-release ropinirole formulations equally efficacious? A rater-blinded, switch-over, multicenter study. Parkinsons Disease, 2014, 158353.

    Google Scholar 

  90. Deli, G., Balas, I., Komoly, S., Doczi, T., Janszky, J., Illes, Z., et al. (2012). Treatment of dystonia by deep brain stimulation: a summary of 40 cases. Ideggyogyaszati Szemle, 65(7–8), 249–260.

    PubMed  Google Scholar 

  91. Ersek, K., Kovacs, T., Wimo, A., Karpati, K., Brodszky, V., Pentek, M., et al. (2010). Costs of dementia in Hungary. The Journal of Nutrition, Health & Aging, 14(8), 633–639.

    Article  CAS  Google Scholar 

  92. Gombos, T., Kertesz, K., Csikos, A., Soderhamn, U., Soderhamn, O., & Prohaszka, Z. (2008). Nutritional form for the elderly is a reliable and valid instrument for the determination of undernutrition risk, and it is associated with health-related quality of life. Nutrition Research, 28(2), 59–65.

    Article  CAS  PubMed  Google Scholar 

  93. Hanko, B., Kazmer, M., Kumli, P., Hragyel, Z., Samu, A., Vincze, Z., et al. (2007). Self-reported medication and lifestyle adherence in Hungarian patients with Type 2 diabetes. Pharmacy World & Science, 29(2), 58–66.

    Article  Google Scholar 

  94. Herceg, M., Nagy, F., Pal, E., Janszky, J., Kesmarky, I., Komoly, S., et al. (2012). Pramipexole may be an effective treatment option in essential tremor. Clinical Neuropharmacology, 35(2), 73–76.

    Article  CAS  PubMed  Google Scholar 

  95. Heredi, E., Rencz, F., Balogh, O., Gulacsi, L., Herszenyi, K., Hollo, P., et al. (2014). Exploring the relationship between EQ-5D, DLQI and PASI, and mapping EQ-5D utilities: a cross-sectional study in psoriasis from Hungary. The European Journal of Health Economics, 15(Suppl 1), S111–119.

    Article  PubMed  Google Scholar 

  96. Horvath, K., Aschermann, Z., Acs, P., Deli, G., Janszky, J., Karadi, K., et al. (2014). Test-retest validity of Parkinson’s disease sleep scale 2nd version (PDSS-2). Journal of Parkinson’s Disease, 4(4), 687–691.

    PubMed  Google Scholar 

  97. Kiraly, E., & Gondos, T. (2012). Cardiovascular diseases and the health-related quality of life after total hip replacement. Journal of Clinical Nursing, 21(19–20), 2843–2850.

    Article  PubMed  Google Scholar 

  98. Kovacs, C., Pecze, M., Tihanyi, A., Kovacs, L., Balogh, S., & Bender, T. (2012). The effect of sulphurous water in patients with osteoarthritis of hand. Double-blind, randomized, controlled follow-up study. Clinical Rheumatology, 31(10), 1437–1442.

    Article  PubMed  Google Scholar 

  99. Kovacs, N., Aschermann, Z., Acs, P., Bosnyak, E., Deli, G., Janszky, J., et al. (2014). The impact of levodopa-carbidopa intestinal gel on health-related quality of life in Parkinson’s disease. Ideggyogyaszati Szemle, 67(7–8), 245–250.

    PubMed  Google Scholar 

  100. Kulisch, A., Benko, A., Bergmann, A., Gyarmati, N., Horvath, H., Kranicz, A., et al. (2014). Evaluation of the effect of Lake Heviz thermal mineral water in patients with osteoarthritis of the knee: A randomized, controlled, single-blind, follow-up study. European Journal of Physical Rehabilation Medicine, 50(4), 373–381.

    CAS  Google Scholar 

  101. Pentek, M., Gulacsi, L., Majoros, A., Piroth, C., Rubliczky, L., Boszormenyi Nagy, G., et al. (2012). Health related quality of life and productivity of women with overactive bladder. Orvosi Hetilap, 153(27), 1068–1076.

    Article  PubMed  Google Scholar 

  102. Pentek, M., Gulacsi, L., Rojkovich, B., Brodszky, V., van Exel, J., & Brouwer, W. B. (2014). Subjective health expectations at biological therapy initiation: a survey of rheumatoid arthritis patients and rheumatologists. The European Journal of Health Economics, 15(Suppl 1), S83–92.

    Article  PubMed  Google Scholar 

  103. Pentek, M., Harangozo, J., Egerhazi, A., Kelemen, O., Gulacsi, L., Baji, P., et al. (2012). Health related quality of life and disease burden of patients with schizophrenia in Hungary. Psychiatria Hungarica, 27(1), 4–17.

    PubMed  Google Scholar 

  104. Rencz, F., Kovacs, A., Brodszky, V., Gulacsi, L., Nemeth, Z., Nagy, G. J., et al. (2015). Cost of illness of medically treated benign prostatic hyperplasia in Hungary. International Urology and Nephrology, 47(8), 1241–1249.

    Article  PubMed  Google Scholar 

  105. Tamas, G., Gulacsi, L., Bereczki, D., Baji, P., Takats, A., Brodszky, V., et al. (2014). Quality of life and costs in Parkinson’s disease: a cross sectional study in Hungary. PLoS One, 9(9), e107704.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  106. Tefner, I. K., Gaal, R., Koroknai, A., Rathonyi, A., Gati, T., Monduk, P., et al. (2013). The effect of Neydharting mud-pack therapy on knee osteoarthritis: a randomized, controlled, double-blind follow-up pilot study. Rheumatology International, 33(10), 2569–2576.

    Article  PubMed  Google Scholar 

  107. Tefner, I. K., Kovacs, C., Gaal, R., Koroknai, A., Horvath, R., Badruddin, R. M., et al. (2015). The effect of balneotherapy on chronic shoulder pain. A randomized, controlled, single-blind follow-up trial. A pilot study. Clinical Rheumatology, 34(6), 1097–1108.

    Article  PubMed  Google Scholar 

  108. Tefner, I. K., Nemeth, A., Laszlofi, A., Kis, T., Gyetvai, G., & Bender, T. (2012). The effect of spa therapy in chronic low back pain: a randomized controlled, single-blind, follow-up study. Rheumatology International, 32(10), 3163–3169.

    Article  PubMed  Google Scholar 

  109. Bokor, M., & Szentesi, A. (2010). The effect of Stalevo-dosing on quality of life of Parkinsonian patients with wearing-off. Ideggyogyaszati Szemle, 63(7–8), 247–251.

    PubMed  Google Scholar 

  110. Brodszky, V., Pentek, M., Blint, P. V., Geher, P., Hajdu, O., Hodinka, L., et al. (2010). Comparison of the Psoriatic Arthritis Quality of Life (PsAQoL) questionnaire, the functional status (HAQ) and utility (EQ-5D) measures in psoriatic arthritis: Results from a cross-sectional survey. Scandinavian Journal of Rheumatology, 39(4), 303–309.

    Article  CAS  PubMed  Google Scholar 

  111. Klivenyi, P., & Vecsei, L. (2008). The use of Stalevo in Hungary for patients with Parkinson disease and its effect on the quality of life. Ideggyogyaszati Szemle, 61(1–2), 42–48.

    PubMed  Google Scholar 

  112. Meszaros, A., & Vincze, Z. (2003). Analysis of quality of life among patients with bronchial asthma or rheumatoid arthritis. Orvosi Hetilap, 144(9), 423–427.

    PubMed  Google Scholar 

  113. Pentek, M., Bereczki, D., Gulacsi, L., Mikudina, B., Aranyi, Z., Juhos, V., et al. (2013). Survey of adults with epilepsy in Hungary: Health related quality of life and costs. Ideggyogyaszati Szemle, 66(7–8), 251–261.

    PubMed  Google Scholar 

  114. Pentek, M., Gulacsi, L., Rozsa, C., Simo, M., Iljicsov, A., Komoly, S., et al. (2012). Health status and costs of ambulatory patients with multiple sclerosis in Hungary. Ideggyogyaszati Szemle, 65(9–10), 316–324.

    PubMed  Google Scholar 

  115. Pentek, M., Szekanecz, Z., Czirjak, L., Poor, G., Rojkovich, B., Polgar, A., et al. (2008). Impact of disease progression on health status, quality of life and costs in rheumatoid arthritis in Hungary. Orvosi Hetilap, 149(16), 733–741.

    Article  PubMed  Google Scholar 

  116. Szende, A., & Molnar, L. (2001). Inequalities in health status and inequity in the delivery of health care in Hungary. Archives of Hellenic Medicine, 18(2), 169–179.

    Google Scholar 

  117. Szende, A., & Nemeth, R. (2003). Health-related quality of life of the Hungarian population. Orvosi Hetilap, 144(34), 1667–1674.

    PubMed  Google Scholar 

  118. Voko, Z., Nemeth, R., Nagyjanosi, L., Jermendy, G., Winkler, G., Hidvegi, T., et al. (2014). Mapping the Nottingham health profile onto the preference-based EuroQol-5D instrument for patients with diabetes. Value in Health Regional Issues, 4, 31–36.

    Article  Google Scholar 

  119. Banaszkiewicz, M., Wawrzonkowska, I., & Andruszkiewicz, A. (2014). The health behaviours and their selected predictors and quality of women’s life in postmenopausal period on the example of the patients of Multi-Municipal Hospital dr E. Warmiński in Bydgoszcz. Przedsiębiorczość i Zarządzanie, 12(1), 263–279.

    Google Scholar 

  120. Borowiak, E., & Barylska, A. (2007). Problems of seniors in House of Day’s Stay—challenge for nurse. Problemy Pielęgniarstwa, 15(1), 13–19.

    Google Scholar 

  121. Farkowski, M. M., Pytkowski, M., Maciag, A., Golicki, D., Wood, K. A., Kowalik, I., et al. (2014). Gender-related differences in outcomes and resource utilization in patients undergoing radiofrequency ablation of supraventricular tachycardia: results from Patients’ Perspective on Radiofrequency Catheter Ablation of AVRT and AVNRT Study. Europace, 16(12), 1821–1827.

    Article  PubMed  Google Scholar 

  122. Golicki, D., Jakubczyk, M., Niewada, M., Wrona, W., & Busschbach, J. J. (2010). Valuation of EQ-5D health states in Poland: first TTO-based social value set in Central and Eastern Europe. Value in Health, 13(2), 289–297.

    Article  PubMed  Google Scholar 

  123. Jarosławska, B., & Błaszczyk, B. (2012). Quality of life of patients after ischamic stroke treated in hospital area of the administrative unit. Studia Medyczne, 26(2), 19–29.

    Google Scholar 

  124. Kołtowski, L., Drohomirecka, A., Palczewski, M., & Cichoń, R. (2011). Short-term improvement of patients’ quality of life after coronary artery bypass grafting—A prospective single-center study based on the EQ-5D assessment tool. Advances in Clinical and Experimental Medicine, 20(4), 447–453.

    Google Scholar 

  125. Kwaśniewska, M., Bielecki, W., & Drygas, W. (2004). Sociodemographic and clinical determinants of quality of life in urban population of Poland. Central European Journal of Public Health, 12(2), 63–68.

    PubMed  Google Scholar 

  126. Kwaśniewska, M., & Drygas, W. (2005). Quality of life in patients with risk factors of coronary heart disease. Przeglad Lekarski, 62(9), 863–870.

    PubMed  Google Scholar 

  127. Pasek, J., Kwiatek, P., Pasek, T., Szajkowski, S., Szewc, A., & Sieroń, A. (2012). Application of magnetic field and visible light in the treatment of low back pain and sciatic neuralgia. Aktualn Neurol, 12(1), 65–68.

    Google Scholar 

  128. Pasek, J., Szajkowski, S., Suszyński, K., Wiaderkiewicz, J., & Kwiek, S. (2009). The quality of life at patients with the extrapyramidal system diseases after stereotactic surgery and rehabilitation. Annales Academiae Medicae Silesiensis, 63(6), 32–39.

    Google Scholar 

  129. Puto, G., Ocetkiewicz, T., & Zawisza, K. (2008). Influence of depression and cognitive function on subjective assessment of quality of life in patients over 80 years old with myocardial ischemia. Gerontologia Polska, 15(3), 90–96.

    Google Scholar 

  130. Skowron, A., & Turska, W. (2008). Assessment of the quality of life among patient witha arterial hypertension and diabetes type 2. Farmacja Polska, 64(17), 745–796.

    Google Scholar 

  131. Uchmanowicz, I., Jankowska, B., Panaszek, B., & Fal, A. M. (2010). The impact of socio-demographic factors on health related quality of life (HRQoL) of patients with asthma. Współczesna Alergologia Info, 5(2), 57–65.

    Google Scholar 

  132. van Hout, B., Janssen, M. F., Feng, Y. S., Kohlmann, T., Busschbach, J., Golicki, D., et al. (2012). Interim scoring for the EQ-5D-5L: mapping the EQ-5D-5L to EQ-5D-3L value sets. Value in Health, 15(5), 708–715.

    Article  PubMed  Google Scholar 

  133. Woźniak, J., Królicka, A., Pokryszko-Draga, A., Włodarczyk, I., Dudek, K., & Włodarczyk, K. (2012). Assessment of overall efficiency, daily living activities and quality of life in elderly adults with suspected dementia. Psychogeriatria Polska, 9(4), 149–160.

    Google Scholar 

  134. Zuraw, W., Golicki, D., Jurecka, A., & Tylki-Szymanska, A. (2011). Quality of life among polish Fabry patients - a cross-sectional study quality of life among polish Fabry patients. Central European Journal of Medicine, 6(6), 741–749.

    Google Scholar 

  135. Borowiak, E., & Kostka, T. (2004). Predictors of quality of life in older people living at home and in institutions. Aging Clinical and Experimental Research, 16(3), 212–220.

    Article  PubMed  Google Scholar 

  136. Deskur-Smielecka, E., Borowicz-Bienkowska, S., Brychcy, A., Wilk, M., Przywarska, I., & Dylewicz, P. (2009). Why patients after acute coronary syndromes do not participate in an early outpatient rehabilitation programme? Kardiologia Polska, 67(6), 632–638.

    PubMed  Google Scholar 

  137. Dudzinska, M., Tarach, J. S., Zwolak, A., Kurowska, M., Malicka, J., Smolen, A., et al. (2013). Type 2 diabetes mellitus in relation to place of residence: evaluation of selected aspects of socio-demographic status, course of diabetes and quality of life–a cross-sectional study. Annals of Agricultural and Environmental Medicine, 20(4), 869–874.

    PubMed  Google Scholar 

  138. Golicki, D., & Niewada, M. (2015). General population reference values for 3-level EQ-5D (EQ-5D-3L) questionnaire in Poland. Polskie Archiwum Medycyny Wewnętrznej, 125(1–2), 18–26.

    PubMed  Google Scholar 

  139. Kaleta, D., & Jegier, A. (2004). Leisure time physical activity and subjective health state in adults. Polskie Archiwum Medycyny Wewnętrznej, 111(5), 537–545.

    PubMed  Google Scholar 

  140. Kleczynski, P., Bagienski, M., Sorysz, D., Rzeszutko, L., Trebacz, J., Tomala, M., et al. (2014). Short- and intermediate-term improvement of patient quality of life after transcatheter aortic valve implantation: a single-centre study. Kardiologia Polska, 72(7), 612–616.

    PubMed  Google Scholar 

  141. Koltowski, L., Koltowska-Haggstrom, M., Filipiak, K. J., Kochman, J., Golicki, D., Pietrasik, A., et al. (2014). Quality of life in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention–radial versus femoral access (from the OCEAN RACE Trial). American Journal of Cardiology, 114(4), 516–521.

    Article  PubMed  Google Scholar 

  142. Machaczka, M., Kampe Bjorkvall, C., Wieremiejczyk, J., Paucar Arce, M., Myhr-Eriksson, K., Klimkowska, M., et al. (2015). Impact of imiglucerase supply shortage on clinical and laboratory parameters in norrbottnian patients with Gaucher disease type 3. Archivum immunolgiae et therapiae experimentalis, 63(1), 65–71.

    Article  Google Scholar 

  143. Maselbas, W., Chabik, G., & Czlonkowska, A. (2010). Persistence with treatment in patients with Wilson disease. Neurologia i Neurochirurgia Polska, 44(3), 260–263.

    Article  CAS  PubMed  Google Scholar 

  144. Matusiak, L., Bieniek, A., & Szepietowski, J. C. (2010). Psychophysical aspects of hidradenitis suppurativa. Acta Dermato Venereologica, 90(3), 264–268.

    Article  PubMed  Google Scholar 

  145. Pierzchala, K., Adamczyk-Sowa, M., Dobrakowski, P., Kubicka-Baczyk, K., Niedziela, N., & Sowa, P. (2015). Demographic characteristics of MS patients in Poland’s upper Silesia region. International Journal of Neuroscience, 125(5), 344–351.

    Article  PubMed  Google Scholar 

  146. Szyca, R., Zimmermann, A., & Leksowski, K. (2010). Influence of low-molecular-weight heparin on the life quality of patients after intravascular medical procedures in comparison to patients who were treated with oral anticoagulants. Polski Merkuriusz Lekarski, 29(171), 157–161.

    PubMed  Google Scholar 

  147. Boros, P. W., & Lubinski, W. (2012). Health state and the quality of life in patients with chronic obstructive pulmonary disease in Poland: A study using the EQ-5D questionnaire. Polskie Archiwum Medycyny Wewnętrznej, 122(3), 73–81.

    PubMed  Google Scholar 

  148. Borowiak, E., & Kostka, T. (2006). Influence of chronic cardiovascular disease and hospitalisation due to this disease on quality of life of community-dwelling elderly. Quality of Life Research, 15(7), 1281–1289.

    Article  PubMed  Google Scholar 

  149. Gierat-Haponiuk, K., Haponiuk, I., Szalewska, D., Chojnicki, M., Jaworski, R., Niedoszytko, P., et al. (2015). Effect of complex cardiac rehabilitation on physical activity and quality of life during long-term follow-up after surgical correction of congenital heart disease. Kardiologia Polska, 73(4), 267–273.

    Article  PubMed  Google Scholar 

  150. Golicki, D., Dudzinska, M., Zwolak, A., & Tarach, J. S. (2015). Quality of life in patients with type 2 diabetes in Poland - comparison with the general population using the EQ-5D questionnaire. Advances in Clinical and Experimental Medicine, 24(1), 139–146.

    Article  PubMed  Google Scholar 

  151. Golicki, D., Niewada, M., Jakubczyk, M., Wrona, W., & Hermanowski, T. (2010). Self-assessed health status in Poland: EQ-5D findings from the Polish valuation study. Polskie Archiwum Medycyny Wewnętrznej, 120(7–8), 276–281.

    PubMed  Google Scholar 

  152. Grabowska, P., Targowski, T., & Jahnz-Rozyk, K. (2006). Evaluation of quality of life and knowledge about tobacco smoking toxicity among patients hospitalized in Department of Pneumonology. Przeglad Lekarski, 63(10), 1071–1074.

    PubMed  Google Scholar 

  153. Jegier, A., Szmigielska, K., Bilinska, M., Brodowski, L., Galaszek, M., Mrozek, P., et al. (2009). Health-related quality of life in patients with coronary heart disease after residential vs ambulatory cardiac rehabilitation. Circulation Journal, 73(3), 476–483.

    Article  PubMed  Google Scholar 

  154. Kaleta, D., & Jegier, A. (2005). Ambulatory cardiac rehabilitation and selected quality of life parameters among men with coronary artery disease. Przeglad Lekarski, 62(7), 657–660.

    PubMed  Google Scholar 

  155. Kostka, J., Borowiak, E., & Kostka, T. (2014). Nutritional status and quality of life in different populations of older people in Poland. European Journal of Clinical Nutrition, 68(11), 1210–1215.

    Article  CAS  PubMed  Google Scholar 

  156. Mitosek-Szewczyk, K., Kulakowska, A., Bartosik-Psujek, H., Hozejowski, R., Drozdowski, W., & Stelmasiak, Z. (2014). Quality of life in Polish patients with multiple sclerosis. Advances in Medical Sciences, 59(1), 34–38.

    Article  PubMed  Google Scholar 

  157. Noone, D., O’Mahony, B., van Dijk, J. P., & Prihodova, L. (2013). A survey of the outcome of prophylaxis, on-demand treatment or combined treatment in 18-35-year old men with severe haemophilia in six countries. Haemophilia, 19(1), 44–50.

    Article  CAS  PubMed  Google Scholar 

  158. Nowakowska-Glab, A., & Maniecka-Bryla, I. (2011). Relation between occupation and health related quality of life of pregnant women. Medycyna Pracy, 62(6), 601–607.

    PubMed  Google Scholar 

  159. Nowakowska-Glab, A., Maniecka-Bryla, I., Wilczynski, J., & Nowakowska, D. (2010). Evaluation of antenatal quality of life of hospitalized women with the use of Mother-Generated Index–pilot study. Ginekologia Polska, 81(7), 521–527.

    PubMed  Google Scholar 

  160. Salabura, B., Klimek-Poskorz, E., & Sokol, B. (2005). The quality of life in patients after myocardial infraction treated with coronary angioplasty. Fizjoterapia, 13(3), 33–41.

    Google Scholar 

  161. Wrobel, M. P., Szymborska-Kajanek, A., Wystrychowski, G., Biniszkiewicz, T., Sieron-Stoltny, K., Sieron, A., et al. (2008). Impact of low frequency pulsed magnetic fields on pain intensity, quality of life and sleep disturbances in patients with painful diabetic polyneuropathy. Diabetes and Metabolism, 34(4), 349–354.

    Article  CAS  PubMed  Google Scholar 

  162. Golicki, D., Niewada, M., Buczek, J., Karlińska, A., Kobayashi, A., Janssen, M. F., et al. (2015). Validity of EQ-5D-5L in stroke. Quality of Life Research, 24(4), 845–850.

    Article  PubMed  Google Scholar 

  163. Kostka, T., & Bogus, K. (2007). Independent contribution of overweight/obesity and physical inactivity to lower health-related quality of life in community-dwelling older subjects. Zeitschrift für Gerontologie und Geriatrie, 40(1), 43–51.

    Article  CAS  PubMed  Google Scholar 

  164. Kostka, T., & Jachimowicz, V. (2010). Relationship of quality of life to dispositional optimism, health locus of control and self-efficacy in older subjects living in different environments. Quality of Life Research, 19(3), 351–361.

    Article  PubMed  Google Scholar 

  165. Łabuz-Roszak, B., Kubicka-Bączyk, K., Pierzchała, K., Horyniecki, M., Machowska-Majchrzak, A., Augustyńska-Mutryn, D., et al. (2013). Quality of life in multiple sclerosis—Association with clinical features, fatigue and depressive syndrome. Psychiatria Polska, 47(3), 433–441.

    PubMed  Google Scholar 

  166. Golicki, D., & Niewada, M. (2015). EQ-5D-5L Polish population norms. Archives of Medical Science. doi:10.5114/aoms.2015.52126.

    Google Scholar 

  167. Golicki, D., Niewada, M., Karlinska, A., Buczek, J., Kobayashi, A., Janssen, M. F., et al. (2015). Comparing responsiveness of the EQ-5D-5L, EQ-5D-3L and EQ VAS in stroke patients. Quality of Life Research, 24(6), 1555–1563.

    Article  PubMed  Google Scholar 

  168. Khoshab, H. A., & Sloboda, T. (2015). Minimal access spinal technologies (MAST) fusion procedures for the treatment of the degenerative lumbar spine (a part of multicentral prospective study). Case Report. Neuroendocrinology Letters, 36(3), 231–235.

    PubMed  Google Scholar 

  169. Klepanec, A., Mistrik, M., Altaner, C., Valachovicova, M., Olejarova, I., Slysko, R., et al. (2012). No difference in intra-arterial and intramuscular delivery of autologous bone marrow cells in patients with advanced critical limb ischemia. Cell Transplantation, 21(9), 1909–1918.

    Article  PubMed  Google Scholar 

  170. Rosa, J., Vanuga, P., Noskovic, M., & Ritomsky, A. (2004). Profile of patients presenting with postmenopausal osteoporosis treated with raloxifene. Osteologicky Bulletin, 9(1), 18–21.

    Google Scholar 

  171. Dernovsek, M. Z., Prevolnik Rupel, V., Rebolj, M., & Tavcar, R. (2001). Quality of life and treatment costs in schizophrenic outpatients, treated with depot neuroleptics. European Psychiatry, 16(8), 474–482.

    Article  CAS  PubMed  Google Scholar 

  172. Kersnik, J. (2000). Observational study of home visits in Slovene general practice: patient characteristics, practice characteristics and health care utilization. Family Practice, 17(5), 389–393.

    Article  CAS  PubMed  Google Scholar 

  173. Klemenc-Ketis, Z. (2011). Disability in patients with chronic non-specific low back pain: validation of the Slovene version of the Oswestry Disability Index. Zdravstveno Varstvo, 50(2), 87–94.

    Google Scholar 

  174. Klemenc-Ketis, Z., & Kersnik, J. (2014). Health seeking behaviour in general population with psychological symptoms. Psychiatria Danubina, 26(2), 181–186.

    PubMed  Google Scholar 

  175. Klemenc-Ketis, Z., Kersnik, J., Eder, K., & Colaric, D. (2011). Factors associated with health-related quality of life among university students. Srpski Arhiv za Celokupno Lekarstvo, 139(3–4), 197–202.

    Article  PubMed  Google Scholar 

  176. Klemenc-Ketis, Z., Smogavec, M., Softic, N., & Kersnik, J. (2011). Health-related quality of life: a population based study from Slovenia. Central European Journal of Public Health, 19(1), 7–12.

    PubMed  Google Scholar 

  177. Korosec Jagodic, H., Jagodic, K., & Podbregar, M. (2006). Long-term outcome and quality of life of patients treated in surgical intensive care: A comparison between sepsis and trauma. Critical Care, 10(5), R134.

    Article  PubMed  PubMed Central  Google Scholar 

  178. Pavsic, K., Pelicon, K., Ledinek, A. H., & Sega, S. (2015). Short-term impact of fampridine on motor and cognitive functions, mood and quality of life among multiple sclerosis patients. Clinical Neurology and Neurosurgery, 139, 35–40.

    Article  PubMed  Google Scholar 

  179. Prevolnik Rupel, V., & Ogorevc, M. (2014). Use of the EQ-5D instrument and value scale in comparing health states of patients in four health care programs among health care providers. Value in Health Regional Issues, 4, 95–99.

    Article  Google Scholar 

  180. Zelko, E., Svab, I., & Pavlic, D. R. (2015). Quality of life and patient satisfaction with family practice care in a Roma Population with chronic conditions in northeast Slovenia. Zdravstveno Varstvo, 54(1), 18–26.

    PubMed  Google Scholar 

  181. Prevolnik Rupel, V., Marušič, D., & S, K. (2005). Quality of life of the coronary club members. Zdravstveno Varstvo, (44), 151–160.

  182. Rebolj, M., & Prevolnik Rupel, V. (2001). Socioeconomic inequalities in health of the Slovenian population measured by the EQ-5D instrument. In A. Norinder, P. KM, & P. Roos (Eds.), Proceedings of the 18th of the EuroQol Group, 6 th –7th September, 2001, Copanhagen, Denmark (pp. 199–213).

  183. Borowiak, E., & Kostka, T. (2003). Physical activity of elderly inhabitants of Lodz. Polish Journal of Sports Medicine, 19(4), 139–146.

    Google Scholar 

  184. Golicki, D., Niewada, M., Hout, B. V., Janssen, M. F., & Pickard, A. S. (2014). Interim EQ-5D-5L value set for Poland: First crosswalk value set in central and eastern Europe. Value in Health Regional Issues, 4(1), 19–23.

    Article  Google Scholar 

  185. Prevolnik Rupel, V., & Ogorevc, M. (2012). The EQ-5D health states value set for Slovenia. Zdravstveno Varstvo, 51(2), 128–140.

    Google Scholar 

  186. Gulacsi, L., Boncz, I., & Drummond, M. (2004). Issues for countries considering introducing the “fourth hurdle”: the case of Hungary. International Journal of Technology Assessment in Health Care, 20(3), 337–341.

    Article  PubMed  Google Scholar 

  187. Gulacsi, L., Brodszky, V., Pentek, M., Varga, S., Vas, G., & Boncz, I. (2009). History of health technology assessment in Hungary. International Journal of Technology Assessment in Health Care, 25(Suppl 1), 120–126.

    Article  PubMed  Google Scholar 

  188. Nizankowski, R., & Wilk, N. (2009). From idealistic rookies to a regional leader: The history of health technology assessment in Poland. International Journal of Technology Assessment in Health Care, 25(Suppl 1), 156–162.

    Article  PubMed  Google Scholar 

  189. Prosser, L. A., Lamarand, K., Gebremariam, A., & Wittenberg, E. (2015). Measuring family HRQoL spillover effects using direct health utility assessment. Medical Decision Making, 35(1), 81–93.

    Article  PubMed  PubMed Central  Google Scholar 

  190. Wittenberg, E., & Prosser, L. A. (2013). Disutility of illness for caregivers and families: A systematic review of the literature. Pharmacoeconomics, 31(6), 489–500.

    Article  PubMed  PubMed Central  Google Scholar 

  191. Wittenberg, E., Ritter, G. A., & Prosser, L. A. (2013). Evidence of spillover of illness among household members: EQ-5D scores from a US sample. Medical Decision Making, 33(2), 235–243.

    Article  PubMed  Google Scholar 

  192. Tilford, J. M., & Payakachat, N. (2015). Progress in measuring family spillover effects for economic evaluations. Expert Rev Pharmacoecon Outcomes Res, 15(2), 195–198.

    Article  PubMed  Google Scholar 

  193. Brooks, R. (2012). The EuroQol Group After 25 Years. Berlin: Springer.

    Google Scholar 

  194. Rabin, R., Oemar, M., & Oppe, M. (2011). EQ-5D-3L user guide: Basic information on how to use the EQ-5D-3L instrument. Rotterdam: EuroQol Group.

    Google Scholar 

  195. Kolasa, K., Schubert, S., Manca, A., & Hermanowski, T. (2011). A review of Health Technology Assessment (HTA) recommendations for drug therapies issued between 2007 and 2009 and their impact on policymaking processes in Poland. Health Policy, 102(2–3), 145–151.

    Article  PubMed  Google Scholar 

  196. Kolasa, K., & Wasiak, R. (2012). Health technology assessment in Poland and Scotland: comparison of process and decisions. International Journal of Technology Assessment in Health Care, 28(1), 70–76.

    Article  PubMed  Google Scholar 

  197. Niewada, M., Polkowska, M., Jakubczyk, M., & Golicki, D. (2013). What influences recommendations issued by the agency for health technology assessment in Poland? A glimpse into decision makers’ preferences. Value in Health Regional Issues, 2(2), 267–272.

    Article  Google Scholar 

  198. Knies, S., Evers, S. M., Candel, M. J., Severens, J. L., & Ament, A. J. (2009). Utilities of the EQ-5D: transferable or not? Pharmacoeconomics, 27(9), 767–779.

    Article  PubMed  Google Scholar 

  199. Knott, R. J., Black, N., Hollingsworth, B., & Lorgelly, P. K. (2016). Response-Scale Heterogeneity in the EQ-5D. Health Econ. doi:10.1002/hec.3313.

  200. Gunther, O. H., Roick, C., Angermeyer, M. C., & Konig, H. H. (2008). The responsiveness of EQ-5D utility scores in patients with depression: A comparison with instruments measuring quality of life, psychopathology and social functioning. Journal of Affective Disorders, 105(1–3), 81–91.

    Article  PubMed  Google Scholar 

  201. Heijink, R., van Baal, P., Oppe, M., Koolman, X., & Westert, G. (2011). Decomposing cross-country differences in quality adjusted life expectancy: The impact of value sets. Population Health Metrics, 9(1), 17.

    Article  PubMed  PubMed Central  Google Scholar 

  202. Matter-Walstra, K., Klingbiel, D., Szucs, T., Pestalozzi, B. C., & Schwenkglenks, M. (2014). Using the EuroQol EQ-5D in Swiss cancer patients, which value set should be applied? Pharmacoeconomics, 32(6), 591–599.

    Article  PubMed  Google Scholar 

  203. Norman, R., Cronin, P., Viney, R., King, M., Street, D., & Ratcliffe, J. (2009). International comparisons in valuing EQ-5D health states: A review and analysis. Value in Health, 12(8), 1194–1200.

    Article  PubMed  Google Scholar 

  204. Stark, R. G., Reitmeir, P., Leidl, R., & Konig, H. H. (2010). Validity, reliability, and responsiveness of the EQ-5D in inflammatory bowel disease in Germany. Inflammatory Bowel Diseases, 16(1), 42–51.

    Article  PubMed  Google Scholar 

  205. Bernert, S., Fernandez, A., Haro, J. M., Konig, H. H., Alonso, J., Vilagut, G., et al. (2009). Comparison of different valuation methods for population health status measured by the EQ-5D in three European countries. Value in Health, 12(5), 750–758.

    Article  PubMed  Google Scholar 

  206. Greiner, W., Weijnen, T., Nieuwenhuizen, M., Oppe, S., Badia, X., Busschbach, J., et al. (2003). A single European currency for EQ-5D health states. Results from a six-country study. The European Journal of Health Economics, 4(3), 222–231.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Health Economics, Corvinus University of Budapest, Fővám tér 8., Budapest, H-1093, Hungary

    Fanni Rencz, László Gulácsi, Valentin Brodszky, Petra Baji & Márta Péntek

  2. Semmelweis University Doctoral School of Clinical Medicine, Üllői út 26., Budapest, H-1085, Hungary

    Fanni Rencz

  3. Centre for Health Economics, University of York, Heslington, York, YO10 5DD, UK

    Michael Drummond

  4. Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland, ul. Banacha 1b, 02-097, Warsaw, Poland

    Dominik Golicki

  5. Institute for Economic Research, Kardeljeva ploščad 17, 1000, Ljubljana, Slovenia

    Valentina Prevolnik Rupel

  6. Department of Health Economics, Centre for Public Health, Medical University of Vienna, Kinderspitalgasse 15/1, 1090, Vienna, Austria

    Judit Simon

  7. Institute of Health Policy and Management, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands

    Elly A. Stolk

  8. Institute of Rheumatology, 1st Faculty of Medicine, Charles University, Na Slupi 4, 128 00, Prague, Czech Republic

    Jakub Závada

  9. Department of Social Pharmacy and Pharmacoeconomics, Faculty of Pharmacy, Medical University, Sofia, Bulgaria

    Guenka Petrova

  10. Department of Social Medicine, University of Amsterdam, Meibergdreef 9, 22660, 1100 DD, Amsterdam, The Netherlands

    Alexandru Rotar

Authors
  1. Fanni Rencz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. László Gulácsi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael Drummond
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dominik Golicki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Valentina Prevolnik Rupel
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Judit Simon
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Elly A. Stolk
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Valentin Brodszky
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Petra Baji
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Jakub Závada
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Guenka Petrova
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Alexandru Rotar
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Márta Péntek
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to László Gulácsi.

Ethics declarations

Conflict of interest

FR, LG, MD, JS, VB, PB, JZ, GP and MP have nothing to disclose. DG reports grants and non-financial support from EuroQol Group, outside the submitted work, and he is a member of the EuroQol Group, a not-for-profit organisation that develops and distributes instruments that assess and value health. VPR is member of the EuroQol Group. EAS is currently employed by EuroQol Research Foundation. In her previous position as academic she has received unrestricted several research grants from EuroQol to conduct EQ-5D related methodological research, outside the submitted work. AR is a salaried employee of Sanofi-Aventis Romania. The review is strictly the personal point of view of the author, and it does not reflect the position of Sanofi-Aventis Romania.

Ethical standard

No ethical approval is required because this is a systematic review.

Informed consent

Informed consent is not required because this is a systematic review

Appendix

Appendix

See Table 3.

Table 3 Lowest mean EQ-5D index and EQ VAS scores by country
Full size table

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rencz, F., Gulácsi, L., Drummond, M. et al. EQ-5D in Central and Eastern Europe: 2000–2015. Qual Life Res 25, 2693–2710 (2016). https://doi.org/10.1007/s11136-016-1375-6

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11136-016-1375-6

Keywords

Search

Navigation