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Patient-reported outcomes in the practice-based opportunities for weight reduction (POWER) trial

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Abstract

Purpose

To evaluate effects of two behavioral weight-loss interventions (in-person, remote) on health-related quality of life (HRQOL) compared to a control intervention.

Methods

Four hundred and fifty-one obese US adults with at least one cardiovascular risk factor completed five measures of HRQOL and depression: MOS SF-12 physical component summary (PCS) and mental component summary; EuroQoL-5 dimensions single index and visual analog scale; PHQ-8 depression symptoms; and PSQI sleep quality scores at baseline and 6 and 24 months after randomization. Change in each outcome was analyzed using outcome-specific mixed-effects models controlling for participant demographic characteristics.

Results

PCS-12 scores over 24 months improved more among participants in the in-person active intervention arm than among control arm participants (P < 0.05, ES = 0.21); there were no other statistically significant treatment arm differences in HRQOL change. Greater weight loss was associated with improvements in most outcomes (P < 0.05 to < 0.0001).

Conclusions

Participants in the in-person active intervention improved more in physical function HRQOL than participants in the control arm did. Greater weight loss during the study was associated with greater improvement in all PRO except for sleep quality, suggesting that weight loss is a key factor in improving HRQOL.

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Acknowledgments

Supported by grants from the National Heart, Lung, and Blood Institute (HL087085), the Prevention and Control Core of the Baltimore Diabetes Research and Training Center (P60DK079637), and the National Center for Research Resources (UL1RR025005) and Healthways. We thank the participants in the POWER trial, who made this study possible; the members of the data safety and monitoring board; several organizations that provided assistance with the conduct of the trial—Johns Hopkins ProHealth, Healthways, Centennial Medical Center, Johns Hopkins Community Physicians, and Park Medical Associates; and a number of persons who contributed to the success of the trial but are not authors.

Conflict of interest

Dr. Louis reports receiving consulting fees from Bristol-Meyers Squibb and Merck and royalties from Taylor and Francis Publishing. Johns Hopkins University has an institutional consulting agreement with Healthways. No other potential conflict of interest relevant to this article was reported.

Author information

Authors and Affiliations

  1. Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    R. R. Rubin, N.-Y. Wang, G. J. Jerome, S. L. Fitzpatrick, W. L. Bennett, A. Dalcin, G. Daumit, N. Durkin, Y.-T. Chang, H.-C. Yeh & L. J. Appel

  2. Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    R. R. Rubin

  3. Department of Sociology, Loyola University Maryland, Baltimore, MD, USA

    M. Peyrot

  4. Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University, Baltimore, MD, USA

    N.-Y. Wang, S. L. Fitzpatrick, W. L. Bennett, G. Daumit, N. Durkin, Y.-T. Chang, H.-C. Yeh & L. J. Appel

  5. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    N.-Y. Wang & T. A. Louis

  6. Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    J. W. Coughlin

  7. Department of Kinesiology, Towson University, Towson, MD, USA

    G. J. Jerome

  8. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    H.-C. Yeh & L. J. Appel

  9. 946 E. Piney Hill Road, Monkton, MD, 21111, USA

    R. R. Rubin

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  1. R. R. Rubin
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  2. M. Peyrot
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  9. G. Daumit
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  13. T. A. Louis
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Correspondence to M. Peyrot.

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Rubin, R.R., Peyrot, M., Wang, NY. et al. Patient-reported outcomes in the practice-based opportunities for weight reduction (POWER) trial. Qual Life Res 22, 2389–2398 (2013). https://doi.org/10.1007/s11136-013-0363-3

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  • DOI: https://doi.org/10.1007/s11136-013-0363-3

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