Abstract
Purpose
To investigate the statistical relationship between the OM8-30 health-related quality of life measure for children with otitis media with effusion (OME) and measures of health utility (Health Utilities Index [HUI] Mark 3 and Mark 2) and to develop models to estimate HUI3 and HUI2 health utilities from OM8-30 scores.
Methods
A placebo-controlled, randomised trial (GNOME) evaluating intranasal mometasone in 217 children with OME provided concurrent responses to OM8-30 and HUI at three time points. Ordinary least squares (OLS), generalised linear models and two-step regression analyses were used to predict HUI3 and HUI2 utilities based on OM8-30 facet and domain scores.
Results
OLS models including all nine OM8-30 facets with or without predicted hearing level (HL) produced the best predictions of HUI3 utilities (mean absolute error: 0.134 with HL and 0.132 without; R 2: 0.63 with HL and 0.596 without). An OLS model predicting HUI3 utilities based on the two OM8-30 domain scores, reported hearing difficulties, predicted HL, age and sex also produced accurate predictions.
Conclusion
Regression equations predicting HUI3 and HUI2 utilities based on OM8-30 facet and domain scores have been developed. These provide an empirical basis for estimating quality-adjusted life years (QALYs) for interventions in children with OME.
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Abbreviations
- ACET:
-
Air conduction estimated from tympanometry
- AIC:
-
Akaike information criterion
- DEV:
-
Developmental domain of the OM8-30
- ENT:
-
Ear, nose and throat
- GLM:
-
Generalised linear model(s)
- GNOME:
-
GPRF [General Practice Research Framework] Nasal steroids for Otitis Media with Effusion
- HL:
-
Hearing level
- HRQoL:
-
Health-related quality of life
- HUI:
-
Health Utilities Index
- MAE:
-
Mean absolute error
- MAEVal :
-
Mean absolute error for the validation dataset
- OLS:
-
Ordinary least squares [regression]
- OM8-30:
-
Otitis media questionnaire
- OME:
-
Otitis media with effusion
- PHYS:
-
Physical health domain of the OM8-30
- PQoL:
-
Parent quality of life
- QALY:
-
Quality-adjusted life-year
- RHD:
-
Reported hearing difficulties
- RMSE:
-
Root mean squared error
- SD:
-
Standard deviation
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Acknowledgments
The authors would like to thank all researchers who were involved in the GNOME trial, in addition to the children and parents who participated. In particular, we would like to thank Giselle Abangma for preparing the dataset of HUI utilities, Helen Spencer for preparing datasets of OM8-30 question, facet and domain scores and predicted hearing levels and the two anonymous reviewers for their helpful comments on the manuscript. This project was funded by the UK National Institute for Health Research Health Technology Assessment Programme (project number 01/72/02). The views and opinions expressed are those of the authors and do not necessarily reflect those of the Department of Health.
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Dakin, H., Petrou, S., Haggard, M. et al. Mapping analyses to estimate health utilities based on responses to the OM8-30 otitis media questionnaire. Qual Life Res 19, 65–80 (2010). https://doi.org/10.1007/s11136-009-9558-z
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DOI: https://doi.org/10.1007/s11136-009-9558-z