Abstract
Food insufficiency is associated with medication non-adherence among people living with HIV/AIDS. The current study examines the relationship between hunger and medication adherence in a US urban and peri-urban sample of people living with HIV/AIDS. Men (N = 133) and women (N = 46) living with HIV/AIDS were recruited using snowball sampling and small media in Atlanta, Georgia. Participants completed computerized behavioral interviews that included measures of demographics, food insufficiency, social support, depression, and substance use, and provided blood specimens to determine HIV viral load. Participants also completed monthly unannounced pill counts to prospectively monitor medication adherence over 8 months. Results indicated that 45% of participants were less than 85% adherent to their medications and that food insufficiency was related to non-adherence; nearly half of non-adherent participants reported recent hunger. Geocoding of participant residences showed that 40% lived more than 5 miles from the city center. Multivariable logistic regression controlling for demographics and common factors associated with adherence showed that the interaction between distance from downtown and experiencing hunger significantly predicted non-adherence over and above all other factors. Medication adherence interventions should address access to food, particularly for people living outside of urban centers.
Similar content being viewed by others
References
Anema, A., Vogenthaler, N., Frongillo, E. A., Kadiyala, S., & Weiser, S. D. (2009). Food insecurity and HIV/AIDS: Current knowledge, gaps, and research priorities. Currrent HIV/AIDS Reports, 6, 224–231.
Bangsberg, D. R., & Deeks, S. G. (2010). Spending more to save more: Interventions to promote adherence. Annals of Internal Medicine, 152, 54–56. W-13.
Bangsberg, D. R., Hecht, F. M., Charlebois, E. D., Chesney, M., & Moss, A. (2001). Comparing objective measures of adherence to HIV antiretroviral therapy: Electronic medication monitors and unannounced pill counts. AIDS and Behavior, 5, 275–281.
Bangsberg, D. R., Kroetz, D. L., & Deeks, S. G. (2007). Adherence-resistance relationships to combination HIV antiretroviral therapy. Current HIV/AIDS Reports, 4, 65–72.
Boston, D. (2008). Poverty rates in Georgia. From http://poverty.suite101.com/article.cfm/poverty_in_georgia
Brock, D., Sarason, I., Sarason, B., & Pierce, G. (1996). Simultaneous assessment of perceived global and relationship-specific support. Journal of Social and Personal Relationships, 13, 143–152.
Cantrell, R. A., Sinkala, M., Megazinni, K., Lawson-Marriott, S., Washington, S., Chi, B. H., et al. (2008). A pilot study of food supplementation to improve adherence to antiretroviral therapy among food-insecure adults in Lusaka, Zambia. Journal of Acquired Immune Deficiency Syndromes, 49, 190–195.
Centers for Disease Control and Prevention (2007). HIV/AIDS statistics and surveillance. From http://www.cdc.gov/hiv/topics/surveillance/basic.htm#hivaidsexposure
Conigrave, K. M., Hall, W. D., & Saunders, J. B. (1995). The AUDIT questionnaire: Choosing a cut-off score. Addictions, 90, 1349–1356.
Cook, J. T., & Frank, D. A. (2008). Food security, poverty, and human development in the United States. Annals of the N Y Academy of Sciences, 1136, 193–209.
Elliott, L. J., Blanchard, J. F., Beaudoin, C. M., Green, C. G., Nowicki, D. L., Matusko, P., et al. (2002). Geographical variations in the epidemiology of bacterial sexually transmitted infections in Manitoba, Canada. Sexually Transmitted Infectections, 78, i139–144.
Franke, M. F., Murray, M. B., Munoz, M., Hernandez-Diaz, S., Sebastian, J. L., Atwood, S., et al. (2010). Food insufficiency is a risk factor for suboptimal antiretroviral therapy adherence among HIV-Infected adults in urban Peru. AIDS and Behavior, Published ahead of print, August 17, 2010.
Haberer, J. E., Kahane, J., Kigozi, I., Emenyonu, N., Hunt, P., Martin, J., et al. (2010). Real-time adherence monitoring for HIV antiretroviral therapy. AIDS and Behavior, 14, 1340–1346.
Hall, H., Espinoza, L., Benbow, N., & Hu, Y. W. (2010). Epidemiology of HIV infection in large urban areas in the United States. PLoS ONE, 5, e12756.
Heckman, T. G., & Carlson, B. (2007). A randomized clinical trial of two telephone-delivered, mental health interventions for HIV-infected persons in rural areas of the United States. AIDS and Behavior, 11, 5–14.
Heckman, T. G., Somlai, A. M., Peters, J., Walker, J., Otto-Salaj, L., Galdabini, C. A., et al. (1998). Barriers to care among persons living with HIV/AIDS in urban and rural areas. AIDS Care, 10, 365–375.
Heckman, T. G., Heckman, B. D., Kochman, A., Sikkema, K. J., Suhr, J., & Goodkin, K. (2002). Psychological symptoms among persons 50 years of age and older living with HIV disease. Aging and Mental Health, 6, 121–128.
Heckman, B. D., Catz, S. L., Heckman, T. G., Miller, J. G., & Kalichman, S. C. (2004). Adherence to antiretroviral therapy in rural persons living with HIV disease in the United States. AIDS Care, 16, 219–230.
Ivers, L. C., Cullen, K. A., Freedberg, K. A., Block, S., Coates, J., & Webb, P. (2009). HIV/AIDS, undernutrition, and food insecurity. Clinical Infectious Diseases, 49, 1096–1102.
Ivers, L. C., Chang, Y., Jerome, J. G., & Freedberg, K. A. (2010). Food assistance is associated with improved body mass index, food security and attendance at clinic in an HIV program in central Haiti: A prospective observational cohort study. AIDS Resesearch and Therapy, 7(33).
Kalichman, S. C., Rompa, D., & Cage, M. (2000). Distinguishing between overlapping somatic symptoms of depression and HIV disease in people living with HIV-AIDS. Journal of Nervous and Mental Disorders, 188, 662–670.
Kalichman, S. C., Amaral, C. M., Stearns, H. L., White, D., Flanagan, J. A., Pope, H., et al. (2007). Adherence to antiretroviral therapy assessed by unannounced pill counts conducted by telephone. Journal of General Internal Medicine, 22, 1003–1006.
Kalichman, S. C., Amaral, C. M., Cherry, C., Flanagan, J. A., Pope, H., Eaton, L., et al. (2008). Monitoring antiretroviral adherence by unannounced pill counts conducted by telephone: Reliability and criterion-related validity. HIV Clinical Trials, 9, 298–308.
Kalichman, S. C., Cherry, C., Amaral, C., White, D., Kalichman, M. O., Pope, H., et al. (2010). Health and treatment implications of food insufficiency among people living with HIV/AIDS, Atlanta, Georgia. Journal of Urban Health, 87, 631–641.
Leaver, C. A., Bargh, G., Dunn, J. R., & Hwang, S. W. (2007). The effects of housing status on health-related outcomes in people living with HIV: A systematic review of the literature. AIDS and Behavior, 11, 85–100.
Miller, C. L., Bangsberg, D. R., Tuller, D. M., Senkungu, J., Kawuma, A., Frongillo, E. A., et al. (2010). Food insecurity and sexual risk in an HIV endemic community in Uganda. AIDS and Behavior, Published online ahead of print, April 20, 2010.
Parienti, J. J., Das-Douglas, M., Massari, V., Guzman, D., Deeks, S. G., Verdon, R., et al. (2008). Not all missed doses are the same: Sustained NNRTI treatment interruptions predict HIV rebound at low-to-moderate adherence levels. PLoS ONE, 3, e2783.
Piot, P., Greener, R., & Russell, S. (2007). Squaring the circle: AIDS, poverty, and human development. PLoS Med, 4, 1571–1575.
Radloff, L. S. (1977). The CES-D Scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385–401.
Rosenblum, M., Deeks, S. G., van der Laan, M., & Bangsberg, D. R. (2009). The risk of virologic failure decreases with duration of HIV suppression, at greater than 50% adherence to antiretroviral therapy. PLoS ONE, 4, e7196.
Schleihauf, E., Watkins, R. E., & Plant, A. J. (2009). Heterogeneity in the spatial distribution of bacterial sexually transmitted infections. Sexually Transmitted Infections, 85, 45–49.
Stein, M. D., Herman, D. S., Bishop, D., Anderson, B. J., Trisvan, E., Lopez, R., et al. (2007). A telephone-based intervention for depression in HIV patients: Negative results from a randomized clinical trial. AIDS and Behavior, 11, 15–23.
Vogenthaler, N. S., Hadley, C., Rodriguez, A. E., Valverde, E. E., Del Rio, C., & Metsch, L. R. (2010). Depressive symptoms and food insufficiency among HIV-infected crack users in Atlanta and Miami. AIDS and Behavior, Published online ahead of print, January 23, 2010.
Weiser, S. D., Leiter, K., Bangsberg, D. R., Butler, L. M., Percy-de Korte, F., Hlanze, Z., et al. (2007). Food insufficiency is associated with high-risk sexual behavior among women in Botswana and Swaziland. PLoS Med, 4, 1589–1597. discussion 1598.
Weiser, S. D., Bangsberg, D. R., Kegeles, S., Ragland, K., Kushel, M. B., & Frongillo, E. A. (2009a). Food insecurity among homeless and marginally housed individuals living with HIV/AIDS in San Francisco. AIDSand Behavior, 13, 841–848.
Weiser, S. D., Fernandes, K. A., Brandson, E. K., Lima, V. D., Anema, A., Bangsberg, D. R., et al. (2009b). The association between food insecurity and mortality among HIV-infected individuals on HAART. Journal of Acquired Immune Deficiency Syndromes, 52, 342–349.
Weiser, S. D., Frongillo, E. A., Ragland, K., Hogg, R. S., Riley, E. D., & Bangsberg, D. R. (2009c). Food insecurity is associated with incomplete HIV RNA suppression among homeless and marginally housed HIV-infected individuals in San Francisco. Joural of General Internal Medicine, 24, 14–20.
Author information
Authors and Affiliations
Corresponding author
Additional information
This project was supported by grants from the National Institutes of Health (NIH) grants R01-MH82633 and RC1-AA018983 (SCK), Emory’s Center for AIDS Research NIH grant 2P30-AI-050409 (RFS & AMC) and the Department of Veterans Affairs (RFS).
Rights and permissions
About this article
Cite this article
Kalichman, S.C., Pellowski, J., Kalichman, M.O. et al. Food Insufficiency and Medication Adherence Among People Living with HIV/AIDS in Urban and Peri-Urban Settings. Prev Sci 12, 324–332 (2011). https://doi.org/10.1007/s11121-011-0222-9
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11121-011-0222-9