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Reaction to the paper: Interaction of Polysorbate 80 with Erythropoietin: A Case Study in Protein–Surfactant Interactions

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Abstract

Micelle-associated epoetin is still a possible explanation for the upsurge of pure red blood cell aplasia associated with subcutaneous use of epoetin alpha in patients with chronic renal failure.

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References

  1. A. P. Villalobos S. R. Gunturi G. A. Heavner (2005) ArticleTitleInteraction of polysorbate 80 with erythropoietin: a case study in protein–surfactant interactions Pharm. Res. 22 1186–1194 Occurrence Handle10.1007/s11095-005-5356-7 Occurrence Handle1:CAS:528:DC%2BD2MXmt1yntLk%3D Occurrence Handle16028020

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Authors and Affiliations

  1. Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

    Suzanne Hermeling, Wim Jiskoot, Daan J. A. Crommelin & Huub Schellekens

  2. Department of Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands

    Wim Jiskoot

Authors
  1. Suzanne Hermeling
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  2. Wim Jiskoot
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  3. Daan J. A. Crommelin
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  4. Huub Schellekens
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Hermeling, S., Jiskoot, W., Crommelin, D.J.A. et al. Reaction to the paper: Interaction of Polysorbate 80 with Erythropoietin: A Case Study in Protein–Surfactant Interactions. Pharm Res 23, 641–642 (2006). https://doi.org/10.1007/s11095-006-9573-5

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  • DOI: https://doi.org/10.1007/s11095-006-9573-5

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