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Synthesis of Coumarins Coupled with Benzamides as Potent Antimicrobial Agents

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Pharmaceutical Chemistry Journal Aims and scope

A series of new coumarin derivatives coupled with benzamides have been synthesized and screened for their antimicrobial properties. Some compounds displayed promising antibacterial activity (MIC ranging within 5 – 150 μg/mL) and moderate antifungal activity as compared to the respective standards. Compounds 6p, 6l and 6m displayed promising antibacterial activity comparable with the standard drug ciprofloxacin, and compound 6m exhibited better antifungal activity in comparison to other synthesized compounds. In silico docking studies of the active compounds were carried out against the gyrase enzyme, and it was concluded that compound 6p exhibited significant hydrogen bonding and hydrophobic interactions which could be the plausible reason for its superior activity as compared to the other synthesized compounds.

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Acknowledgements

The authors are thankful to the Department of Industrial Chemistry, Kuvempu University, for rendering the facilities to carry out the experiments. Vasiliy A. Bakulev is thankful for support to the Russian Science Foundation (project No. 18 – 13 – 00161).

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Authors and Affiliations

  1. Innovation Center for Chemical and Pharmaceutical Technologies, Institute of Chemical Technology, Ural Federal University, ul. Mira 19, Yekaterinburg, 620002, Russia

    Muthipeedika Nibin Joy

  2. Department of P. G. Studies and Research in Industrial Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shimoga, Karnataka, 577451, India

    Muthipeedika Nibin Joy & Yadav D. Bodke

  3. TOS Department, Ural Federal University, ul. Mira 19, Yekaterinburg, 620002, Russia

    Vasiliy A. Bakulev

  4. Department of P. G. studies and Research in Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shimoga, Karnataka, 577451, India

    Yadav D. Bodke

  5. Department of P. G. Studies and Research in Biotechnology, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shimoga, Karnataka, 577451, India

    Sandeep Telkar

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  1. Muthipeedika Nibin Joy
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  2. Vasiliy A. Bakulev
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  3. Yadav D. Bodke
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Correspondence to Muthipeedika Nibin Joy.

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Joy, M.N., Bakulev, V.A., Bodke, Y.D. et al. Synthesis of Coumarins Coupled with Benzamides as Potent Antimicrobial Agents. Pharm Chem J 54, 604–621 (2020). https://doi.org/10.1007/s11094-020-02245-4

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  • DOI: https://doi.org/10.1007/s11094-020-02245-4

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