A series of nine molecules of coumarin hydrazone derivatives have been synthesized. The purpose of this study was to investigate the anti-diabetic activity of synthesized coumarin derivatives by inhibition of α-amylase enzyme isolated from Aspergillus niger microbial strain. The experiment was conducted by taking 5, 10, 50, and 100 μg/mL of each compound and acarbose as a positive control. The tests showed that compounds 3f (IC50 = 49.70 μg/mL), 3g (IC50 = 79.20 μg/mL), and 3i (IC50 = 48.80 μg/mL) as well as reference drug (IC50 = 81.70 μg/mL) exhibited inhibition activity against the enzyme. The synthesized compounds may be helpful in controlling the glucose level as α-amylase is one of the causes of increased sugar level in human body.
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The authors are thankful to the Manipal Institute of Technology (MAHE, Manipal) and NMAM Institute of Technology (Nitte) for the facilities provided to carry out this work.
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Shivaprasad Shetty, M., Anil Kumar, H.S. & Anil Kumar, N.V. Synthesis and α-Amylase Inhibition Studies of Some Coumarin Derivatives. Pharm Chem J 52, 526–530 (2018). https://doi.org/10.1007/s11094-018-1853-y
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DOI: https://doi.org/10.1007/s11094-018-1853-y