Methods for the synthesis of 4-chlorophenylsulfonylacetic acid and its tris-(2-hydroxyethyl)ammonium salt (sulfacetamine) were developed. Results of in vitro and in vivo experiments showed that sulfacetamine possessed high antithrombotic, membrane-stabilizing, antioxidant, hypocholesterolemic, and adaptogenic activity with low toxicity to animals.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A. N. Mirskova, G. G. Levkovskaya, R. G. Mirskov, et al., Zh. Org. Khim., 44(10), 1501–1508 (2008).
USSR Inv. Cert. 1,045,569; Izobreteniya. Polezhye Modeli, 15, (2009).
A. N. Mirskova, Yu. I. Kryukova, G. G. Levkovskaya, et al., Zh. Org. Khim., 20(3), 602–608 (1984).
K. Weygand and G. Hilgetag, Organisch-chemische Experimentierkunst, Barth, Leipzig (1964).
J. V. R. Born, Nature, 194, 927–929 (1962).
J. B. Smith, C. M. Ingerman, and M. J. Silber, J. Lab. Clin. Med., 88, 167–172 (1976).
I. A. Terskov and I. I. Gitel?zon, Biofizika, 2, 259–266 (1957).
Yu. M. Lopukhin, Yu. A. Vladimirov, M. N. Molodenkov, et al., Byull. Eksp. Biol. Med., 95(2), 61–63 (1983).
Acknowledgments
We thank Cand. L. N. Kholdeeva, Cand. G. M. Tizenberg, and Can. A. P. Fedoseev for assistance with the biological studies.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 7, pp. 6 – 10, July, 2012.
Rights and permissions
About this article
Cite this article
Mirskova, A.N., Adamovich, S.N. & Mirskov, R.G. Synthesis and pharmacological activity of tris-(2-hydroxyethyl)ammonium 4-chlorophenylsulfonylacetate (sulfacetamine). Pharm Chem J 46, 392–396 (2012). https://doi.org/10.1007/s11094-012-0807-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-012-0807-z