4-Aryl-8-(arylmethylene)-5,6,7,8-tetrahydrospiro[chromen-3,1'-cyclopentan]-2(4H)-ones, 4-aryl-8-(arylme-thylene)-5,6,7,8-tetrahydrospiro[chromen-3,1'-cyclohexan]-2(4H)-ones, and 4-aryl-8-(arylmethylene)5,6,7,8-tetrahydrospiro[chromen-3,1'-cycloheptan]-2(4H)-ones were prepared via the reaction of methyl 1-bromocycloalkanecarboxylates, zinc, and 2,6-bis-(arylmethylene)cyclohexanones. The synthesized compounds exhibited analgesic activity and low toxicity.
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N. F. Kirillov, A. G. Gavrilov, R. R. Makhmudov, and L. G. Mardanova, RF Pat. 2,435,767; Byull. Izobret., No. 34 (2011).
N. F. Kirillov, A. G. Gavrilov, A. N. Vasyanin, et al., Zh. Obshch. Khim., 82(2), 294–298 (2012).
Z. O. Radell and J. J. Selitto, Arch. Int. Pharmacodyn. Ther., 11(4), 409–419 (1957).
M. L. Belen’kii, Elements of Quantitative Assessment of the Pharmacological Effect [in Russian], Leningrad (1963), pp. 81–106.
K. K. Sidorov, Toxicology of New Industrial Chemicals [in Russian], Moscow (1973), No. 13, pp. 47–51.
K. K. Sidorov, Toxicology of New Industrial Chemicals [in Russian], Moscow (1973), No. 13, pp. 47–51.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 5, pp. 9 – 10, May, 2012.
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Kirillov, N.F., Makhmudov, R.R., Gavrilov, A.G. et al. Analgesic activity of 4-aryl-8(arylmethylene)-5,6,7,8-tetrahydrospiro[chromen-3,1'-cycloalkan]-2(4H)-ones. Pharm Chem J 46, 269–270 (2012). https://doi.org/10.1007/s11094-012-0777-1
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DOI: https://doi.org/10.1007/s11094-012-0777-1