A series of new 3-aryl-4-(6′-aryl-imidazo[2,1-b][1,3,4]thiadiazol-2′-yl-phenylsydnones (16 – 27) were synthesized. The structures of the synthesized compounds were confirmed by the IR, 1H NMR, and mass spectroscopy techniques and elemental analysis. All the newly synthesized compounds were evaluated for their anticancer activity against cervical cancer cell line (Hela) and antimicrobial activity, in particular, antitubercular activity against Mycobacterium tuberculosis (H37Rv).
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Acknowledgements
The authors are grateful to the USIC, Karnatak University, Dharwad for carrying out spectral (IR, 1H NMR, MS) analyses. One of the authors (T. M. G.) is grateful to the University for Research Studentship award.
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Gireesh, T.M., Kamble, R.R. & Taj, T. Synthesis and antimicrobial and anticancer activity of new of imidazo[2,1-b][1,3,4]thiadiazoles. Pharm Chem J 45, 313–316 (2011). https://doi.org/10.1007/s11094-011-0624-9
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DOI: https://doi.org/10.1007/s11094-011-0624-9