Skip to main content
SpringerLink
Log in

Synthesis and antimicrobial activity of sulfanilamide-containing copper (II) naphthalidenethiosemicarbazidates

  • The Search for New Therapeutic Substances
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Abstract

Aseries of copper (II) streptocide-, sulfacyl-, norsulfazole-, ethazole-, and sulfadimezine-containing naphthalidenethiosemicarbazidates and napthalidene-4-phenylthiosemicarbazidates with high levels of antimicrobial activity were synthesized. Elemental analysis, magnetochemical, IR spectroscopic, and thermogravimetric data were used to confirm the compositions and structures of the resulting complexes. The effects of the nature of the central atom and the influences of the sulfanilamide and phenyl radicals in the azomethine thiosemicarbazone fragment on the antimicrobial activity of the compounds against 10 strains of Gram positive and Gram negative microorganisms were studied. The most active of the compounds synthesized were the copper norsulfazole-, ethazole-, and sulfadimezine-containing naphthalidenethiosemicarbazidates.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. V. I. Prisakar', V. I. Tsapkov, S. A. Buracheva, et al., Khim.-Farm. Zh., 39, No. 5, 93–95 (2005).

    Google Scholar 

  2. A. B. Tomchin, V. S. Velezheva, and E. B. Shustov, Khim.-Farm. Zh., 32, No. 2, 7–10 (1998).

    CAS  Google Scholar 

  3. O. V. Fedorova, G. G. Mordovskii, G. L. Rusinov, et al., Khim.-Farm. Zh., 32, No. 2, 11–12 (1998).

    CAS  Google Scholar 

  4. K. N. Zelenin, O. B. Kuznetsova, A. G. Saminskaya, et al., Khim.-Farm. Zh., 28, No. 2, 34–37 (1994).

    CAS  Google Scholar 

  5. V. V. Lukov, N. A. Abramova, V. A. Kogan, et al., Zh. Neorg. Khimii, 33, No. 2, 391–396 (1988).

    CAS  Google Scholar 

  6. N. M. Samus', V. I. Prisakar', V. I. Tsapkov, et al., Khim.-Farm. Zh., 38, No. 7, 27–29 (2004).

    Google Scholar 

  7. N. V. Gérbéléu, Author's Abstract of Doctoral Thesis in Chemical Sciences, Moscow (1973).

  8. G. N. Pershin, Methods in Experimental Chemotherapy [in Russian], Meditsina, Moscow (1971), pp. 357–359.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Moldova State University, Kishinev, Moldova

    A. P. Gulya, V. I. Tsapkov, S. N. Spynu & N. P. Bezhenar

  2. N. Testemitsan State University of Medicine and Pharmacy, Kishinev, Moldova

    V. I. Prisakar & S. A. Buracheva

Authors
  1. A. P. Gulya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. I. Prisakar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. I. Tsapkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. A. Buracheva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. N. Spynu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. N. P. Bezhenar
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 6, pp. 19–21, June, 2008.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gulya, A.P., Prisakar, V.I., Tsapkov, V.I. et al. Synthesis and antimicrobial activity of sulfanilamide-containing copper (II) naphthalidenethiosemicarbazidates. Pharm Chem J 42, 326–328 (2008). https://doi.org/10.1007/s11094-008-0118-6

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-008-0118-6

Keywords

Search

Navigation