Abstract
A series of new triterpene hemisuccinates, hemiphthalates and nicotinates have been obtained with 52 – 95% yields via reactions of monoacetates of betulin, betulinic acid, and allobetulin with succinic and phthalic anhydrides and with nicotinic acid chloroanhydride. 3-O-Acetylbetulin-28-O-hemiphthalate showed the most pronounced antiinflammatory activity comparable with the effect of ortophen (diclofenac). 3-O-Acetylbetulin-28-O-hemisuccinate exhibited the most pronounced antiulcer activity comparable with that of carbenoxolone.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 8, pp. 9 – 12, August, 2005.
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Flekhter, O.B., Medvedeva, N.I., Karachurina, L.T. et al. Synthesis and Pharmacological Activity of Betulin, Betulinic Acid, and Allobetulin Esters. Pharm Chem J 39, 401–404 (2005). https://doi.org/10.1007/s11094-005-0167-z
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DOI: https://doi.org/10.1007/s11094-005-0167-z