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Effects of Peroxiredoxin 2 in Neurological Disorders: A Review of its Molecular Mechanisms

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Abstract

Oxidative stress and neuroinflammation are closely related to the pathological processes of neurological disorders. Peroxiredoxin 2 (Prdx2) is an abundant antioxidant enzyme in the central nervous system. Prdx2 reduces the production of reactive oxygen species and participates in regulating various signaling pathways in neurons by catalyzing hydrogen peroxide (H2O2), thereby protecting neurons against oxidative stress and an inflammatory injury. However, the spillage of Prdx2, as damage-associated molecular patterns, accelerates brain damage after stroke by activating an inflammatory response. The post-translational modifications of Prdx2 also affect its enzyme activity. This review focuses on the effects of Prdx2 and its molecular mechanisms in various neurological disorders.

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This work was supported by the National Natural Science Foundation of China (31870335); the Health Industry Planning Project of Gansu Provincial Health and Family Planning Commission (GSWSKY 2016-17); the Science and Technology Major Special Collaboration Project of Gansu Provincial Key Laboratory of Gene Function (BA2016036); the “Cuiying Technology Innovation” Planning Project of Lanzhou University Second Hospital (CY2017-MS19); Cuiying Graduate Supervisor Applicant Training Program Of Lanzhou University Second Hospital (201802).

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  1. Jifei Liu and Gang Su have contributed equally to this work and are co-first authors.

Authors and Affiliations

  1. Department of Neurology, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu, China

    Jifei Liu, Juan Gao, Ye Tian, Xiaoyan Liu & Zhenchang Zhang

  2. Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, Gansu, China

    Gang Su

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  1. Jifei Liu
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  2. Gang Su
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  3. Juan Gao
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  4. Ye Tian
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  5. Xiaoyan Liu
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  6. Zhenchang Zhang
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Correspondence to Zhenchang Zhang.

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Liu, J., Su, G., Gao, J. et al. Effects of Peroxiredoxin 2 in Neurological Disorders: A Review of its Molecular Mechanisms. Neurochem Res 45, 720–730 (2020). https://doi.org/10.1007/s11064-020-02971-x

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  • DOI: https://doi.org/10.1007/s11064-020-02971-x

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