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Crosstalk of Signaling and Metabolism Mediated by the NAD+/NADH Redox State in Brain Cells

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Abstract

The energy metabolism of the brain has to be precisely adjusted to activity to cope with the organ’s energy demand, implying that signaling regulates metabolism and metabolic states feedback to signaling. The NAD+/NADH redox state constitutes a metabolic node well suited for integration of metabolic and signaling events. It is affected by flux through metabolic pathways within a cell, but also by the metabolic state of neighboring cells, for example by lactate transferred between cells. Furthermore, signaling events both in neurons and astrocytes have been reported to change the NAD+/NADH redox state. Vice versa, a number of signaling events like astroglial Ca2+ signals, neuronal NMDA-receptors as well as the activity of transcription factors are modulated by the NAD+/NADH redox state. In this short review, this bidirectional interdependence of signaling and metabolism involving the NAD+/NADH redox state as well as its potential relevance for the physiology of the brain and the whole organism in respect to blood glucose regulation and body weight control are discussed.

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Acknowledgments

We apologize to many colleagues whose work could not be cited owing to space restrictions. Work of the authors’ laboratory was supported by grants from the DFG Hi1414/1-1; Hi1414/2-1 and the German Diabetes Society (J.H.).

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Authors and Affiliations

  1. Faculty of Medicine, Carl-Ludwig-Institute for Physiology, University of Leipzig, Liebigstr. 27, 04103, Leipzig, Germany

    Ulrike Winkler & Johannes Hirrlinger

  2. Department of Neurogenetics, Max-Planck-Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075, Göttingen, Germany

    Johannes Hirrlinger

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  1. Ulrike Winkler
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Correspondence to Johannes Hirrlinger.

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Special Issue: In Honor of Dr. Gerald Dienel.

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Winkler, U., Hirrlinger, J. Crosstalk of Signaling and Metabolism Mediated by the NAD+/NADH Redox State in Brain Cells. Neurochem Res 40, 2394–2401 (2015). https://doi.org/10.1007/s11064-015-1526-0

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