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Hyperbaric Oxygen Therapy Ameliorates Local Brain Metabolism, Brain Edema and Inflammatory Response in a Blast-Induced Traumatic Brain Injury Model in Rabbits

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Abstract

Many studies suggest that hyperbaric oxygen therapy (HBOT) can provide some clinically curative effects on blast-induced traumatic brain injury (bTBI). The specific mechanism by which this occurs still remains unknown, and no standardized time or course of hyperbaric oxygen treatment is currently used. In this study, bTBI was produced by paper detonators equivalent to 600 mg of TNT exploding at 6.5 cm vertical to the rabbit’s head. HBO (100 % O2 at 2.0 absolute atmospheres) was used once, 12 h after injury. Magnetic resonance spectroscopy was performed to investigate the impact of HBOT on the metabolism of local injured nerves in brain tissue. We also examined blood–brain barrier (BBB) integrity, brain water content, apoptotic factors, and some inflammatory mediators. Our results demonstrate that hyperbaric oxygen could confer neuroprotection and improve prognosis after explosive injury by promoting the metabolism of local neurons, inhibiting brain edema, protecting BBB integrity, decreasing cell apoptosis, and inhibiting the inflammatory response. Furthermore, timely intervention within 1 week after injury might be more conducive to improving the prognosis of patients with bTBI.

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Acknowledgments

This study was supported by research Grants from the Nature Science Youth Funding of Anhui Province (1208085QH171) and Nanjing Military Region Fund Project (10MB009). We also thank Professor Bingchang Li (Institute of Battle Surgical Research, Third Military Medicine University) for his support while creating our animal model and Daniel Smerin for his manuscript editing.

Conflict of interest

We have no conflicts of interest to declare.

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Authors and Affiliations

  1. Department of Neurosurgery, No. 105 Hospital of PLA, Anhui Medicine University, Hefei, 230031, People’s Republic of China

    Yongming Zhang, Yanyan Yang, Hong Tang, Wenjiang Sun & Jiachuan Liu

  2. Department of Neurosurgery, Stanford University, Stanford, CA, 94306, USA

    Yongming Zhang & Xiaoxing Xiong

  3. School of Medicine, Stanford University, Stanford, CA, 94306, USA

    Daniel Smerin

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  1. Yongming Zhang
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  2. Yanyan Yang
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  3. Hong Tang
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  7. Jiachuan Liu
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Correspondence to Yongming Zhang or Jiachuan Liu.

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Zhang, Y., Yang, Y., Tang, H. et al. Hyperbaric Oxygen Therapy Ameliorates Local Brain Metabolism, Brain Edema and Inflammatory Response in a Blast-Induced Traumatic Brain Injury Model in Rabbits. Neurochem Res 39, 950–960 (2014). https://doi.org/10.1007/s11064-014-1292-4

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  • DOI: https://doi.org/10.1007/s11064-014-1292-4

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