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Evaluation of Potential Antidepressant-Like Activity of Chalcone-1203 in Various Murine Experimental Depressant Models

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Abstract

Two classic animal behavior despair tests-the forced swimming test (FST) and the tail suspension test (TST) were used to evaluate antidepressant-like activity of a new chalcone compound, chalcone-1203 in mice. It was observed that chalcone-1203 at dose of 1, 5, and 10 mg/kg significantly reduced the immobility time in the FST and TST in mice 30 min after treatment. In addition, chalcone-1203 was found to exhibit significant oral activity in the FST in mice. It also produced a reduction in the ambulation in the open-field test in mice not previously habituated to the arena, but no effect in the locomotor activity in mice previously habituated to the open-field. The main monoamine neurotransmitters and their metabolites in mouse brain regions were also simultaneously determined by HPLC–ECD. It was found that chalcone-1203 significantly increased the concentrations of the main neurotransmitters 5-HT and NE in the hippocampus, hypothalamus and cortex. Chalcone-1203 also significantly reduced the ratio of 5-HIAA/5-HT in the hippocampus and cortex, shown down 5-HT metabolism compared with mice treated with stress vehicle. In conclusion, chalcone-1203 produced significant antidepressant-like activity, and the mechanism of action may be due to increased 5-HT and NE in the mouse hippocampus and cortex.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Nos. 30960458 and 21365023), the Natural Science Foundation of Zhejiang Province of China (No. LY12C19005) and Zhejiang Marine Biotechnology Innovation Team (ZMBIT) (No. 2010R50029).

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Authors and Affiliations

  1. Zhejiang Provincial Key Engineering Technology Research Center of Marine Biomedical Products, Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, 316000, Zhoushan, People’s Republic of China

    Li-Ping Guan, Li-Ming Tang, Cheng-Yan Pan & Shui-Lian Zhao

  2. Analysis and Test Center, Yanbian University, Yanji, 133002, People’s Republic of China

    Si-Hong Wang

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  1. Li-Ping Guan
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  2. Li-Ming Tang
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  3. Cheng-Yan Pan
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  4. Shui-Lian Zhao
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Correspondence to Li-Ping Guan or Si-Hong Wang.

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Guan, LP., Tang, LM., Pan, CY. et al. Evaluation of Potential Antidepressant-Like Activity of Chalcone-1203 in Various Murine Experimental Depressant Models. Neurochem Res 39, 313–320 (2014). https://doi.org/10.1007/s11064-013-1224-8

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