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Synthesis and studies on antidepressant activity of 2′,4′,6′-trihydroxychalcone derivatives

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Abstract

In this study, we synthesized a series of 2′,4′,6′-trihydroxychalcone derivatives and evaluated their antidepressant activities. The results of the nine compounds showed significantly reduced times during the forced swimming test at a dose of 10 mg/kg, indicative of antidepressant activity. Among the compounds, 2-bromo-2′,4′,6′-trihydroxychalcone (3h) was found to be the most potent, and it was observed that compound 3h at dose of 10, 20, and 40 mg/kg significantly reduced the duration of immobility times in the FST and TST in mice 30 min after treatment.

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Acknowledgments

This is provided by Zhejiang Ocean University R&D start funding.

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Authors and Affiliations

  1. Food and Pharmacy College, Zhejiang Ocean University, Zhoushan City, Zhejiang Province, 316004, People’s Republic of China

    Xin Sui, Yin-Feng Xu & Li-Ping Guan

  2. College of Pharmacy, Yanbian University, Yanji, Jilin, 133000, People’s Republic of China

    Xin Sui, Ying-Chun Quan, Yue Chang & Rui-Peng Zhang

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  1. Xin Sui
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  2. Ying-Chun Quan
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  3. Yue Chang
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  4. Rui-Peng Zhang
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Correspondence to Li-Ping Guan.

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Sui, X., Quan, YC., Chang, Y. et al. Synthesis and studies on antidepressant activity of 2′,4′,6′-trihydroxychalcone derivatives. Med Chem Res 21, 1290–1296 (2012). https://doi.org/10.1007/s00044-011-9640-2

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  • DOI: https://doi.org/10.1007/s00044-011-9640-2

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