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Interactions Between Chronic Stress and Chronic Consumption of Caffeine on the Enzymatic Antioxidant System

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An Erratum to this article was published on 12 December 2009

Abstract

We studied the effect of chronic caffeine on parameters related to oxidative stress in different brain regions of stressed and non-stressed rats. Wistar rats were divided into three groups: control (receiving water), caffeine 0.3 g/L and caffeine 1.0 g/L (in the drinking water). These groups were subdivided into non-stressed and stressed (repeated restraint stress during 40 days). Lipid peroxide levels and the total radical-trapping potential were assessed, as well as antioxidant enzyme activities superoxide dismutase, gluthatione peroxidase, and catalase in hippocampus, striatum and cerebral cortex. Results showed interactions between stress and caffeine, especially in the cerebral cortex, since caffeine increased the activity of some antioxidant enzymes, but not in stressed animals. We concluded that chronic administration of caffeine led, in some cases, to increased activity of antioxidant enzymes. However, these effects were not observed in the stressed animals.

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Acknowledgments

Financial support: National Research Council of Brazil (CNPq), FAPERGS-PRONEX and FINEP/Rede IBN 01.06.0842-00.

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Authors and Affiliations

  1. Departamento de Bioquímica, Instituto de Ciências Básica da Saúde, ICBS, UFRGS, Ramiro Barcellos, 2600, anexo., Porto Alegre, RS, 90035-003, Brazil

    Cristie Grazziotin Noschang, Rachel Krolow, Leticia Ferreira Pettenuzzo, Mônica Colpini Ávila, Andrelisa Fachin, Danusa Arcego, Eduardo von Pozzer Toigo, Leonardo Machado Crema, Luísa Amália Diehl, Deusa Vendite & Carla Dalmaz

  2. Programa de Pós-Graduação em Bioquímica, Instituto de Ciências Básica da Saúde, ICBS, UFRGS, Ramiro Barcellos, 2600, anexo., Porto Alegre, RS, 90035-003, Brazil

    Cristie Grazziotin Noschang, Rachel Krolow & Carla Dalmaz

  3. Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básica da Saúde, ICBS, UFRGS, Ramiro Barcellos, 2600, anexo., Porto Alegre, RS, 90035-003, Brazil

    Leonardo Machado Crema, Luísa Amália Diehl & Carla Dalmaz

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  1. Cristie Grazziotin Noschang
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  3. Leticia Ferreira Pettenuzzo
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Corresponding author

Correspondence to Cristie Grazziotin Noschang.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s11064-009-0107-5

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Noschang, C.G., Krolow, R., Pettenuzzo, L.F. et al. Interactions Between Chronic Stress and Chronic Consumption of Caffeine on the Enzymatic Antioxidant System. Neurochem Res 34, 1568–1574 (2009). https://doi.org/10.1007/s11064-009-9945-4

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