Abstract
The purpose of the present study was to determine the relationship between concentration of Zn, Cu and Fe, and the catalase, glutathione peroxidase and superoxide dismutase activities in the heart and liver of newborn rats whose dams were fed a diet supplemented with caffeine. Heart Zn levels of the 22- and 30-day-old rats of the caffeine group showed a decrease, whereas liver Zn levels showed an increase compared to the control. Cu levels in the liver at day 22 in the caffeine group were less than in the control. Cu- and Zn-containing superoxide dismutase activities showed an increase in the hearts of the caffeine group compared to the control. The activity of catalase and glutathion peroxidase showed no difference in the heart and liver between the groups. The present study suggests the possible involvement of superoxide dismutase enzyme in the impairment of heart formation as a result of chronic caffeine intake in the early growing period.
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Literatur
Temples, T. E., Geoffray, D. J., Nakamoto, T., Hartman, A. D., and Miller, H. I., Proc. Soc. exp. Biol. Med.179 (1985) 388.
Temples, T. E., Geoffray, D. J., Nakamoto, T., Hartman, A. D., and Miller, H. I., Pediat. Res.21 (1987) 391.
Johansson, S., Acta path. microbiol. scand.A89 (1981) 185.
Rossowska, M. J., and Nakamoto, T., Br. J. Nutr.64 (1990) 553.
Bray, T. M., and Bettger, W. J., Free Radical Biol. Med.8 (1990) 281.
Lovering, K. E., and Dean, R., Free Radical Res. Commun.14 (1991) 217.
Davis, G. K., Ann. N. Y. Acad. Sci.355 (1980) 130.
Abdel-Mageed, A. B., and Oeheme, F. W., Biol. Trace Element Res.29 (1991) 239.
Harvey, W. K., and Nakamoto, T., Br. J. Nutr.53 (1988) 57.
Nakamoto, T., and Shaye, R., J. Nutr.116 (1986) 633.
Rossowska, M. J., and Nakamoto, T., Pediat. Res.32 (1992) 330.
Nakamoto, T., Joseph, F. Jr, Yazdani, M., and Hartman, A. D., Toxic. Lett.44 (1988) 167.
Beauchamp, C., and fridovich, I., Analyt. Biochem.44 (1971) 276.
Oberley, L. W., and Spitz, D. R., Meth. Enzym.105 (1984) 457.
McCord, J. M., and Fridovich, I., J. biol. Chem.244 (1969) 6049.
Prohaska, J. R., and Gutsch, D. E., Biol. Trace Elem. Res.5 (1983) 35.
Cohen, G., Dembiec, D., and Markus, J., Analyt. Chem.34 (1970) 30.
Aebi, H., in: Methods of Enzymatic Analysis, vol III, 3rd edn, p. 273. Ed. H. U. Bergmeyer. Weinheim-Deerfield Beach, Florida-Basel, 1983.
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem.193 (1951) 265.
Bonati, M., and Garottini, S., in: Caffeine, p. 50. Ed. P. B. Davis. Springer-Verlag, New York 1984.
Weidner, G., and Istvan, V., N. Engl. J. Med.313 (1985) 1421.
Pasternak, C. A., Biosci. Rep.81 (1978) 81.
Bettger, W. J., and O'Dell, B. L., Life Sci.28 (1981) 1425.
Keen, C. L., and Hurley, L. S., Mech. Ageing Dev.13 (1976) 161.
Dungan, D. D., Keen, C. L., Lönnerdal, B., and Hurley, L. S., Fedn Proc.39 (1980) 903.
Willson, J. X., Lui, E. M. K., and DelMaestro, R. F., Mech. Ageing Dev.65 (1992) 51.
Tearo, T., and Owen, C. A., Am. J. Physiol.232 (1977) E172.
Bettger, W. J., and O'Dell, B. L., J. Nutr. Biochem.4 (1993) 194.
Labbe, M. R., and Fisher, P. W. F., J. Nutr.114 (1984) 813.
Paynter, D. I., Moir, R. J., and Underwood, E. J., J. Nutr.109 (1979) 1570.
Bettger, W. J., and Bray, T. M., Nutr. Res.9 (1989) 319.
Harris, E. D., J. Nutr.122 (1992) 636.
Randhawa, P., Mass, P., Franklin, L., and Massaro, D., Pediat. Res.20 (1986) 895.
Vladimirov, Y. A., Olenov, V. I., Suslova, T. B., and Cheremisina, Z. P., Adv. Lipid Res.17 (1980) 173.
Malis, C. D., and Bonventre, J. V., Prog. Clin. Biol. Res.282 (1988) 235.
Zhang, Y., Marcillat, O., Guilive, C., Ernster, L., and Davies, K. J. A., J. biol. Chem.265 (1990) 16330.
Aust, S. D., Morehouse, L. A., and Thomas, C. E. J., Free Radical Biol. Med.1 (1985) 3.
Konno, N., Baba, A., Looper, K. J., and Kako, K., Free Radical Biol. Med.9 Suppl. (1990) 96.
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Rossowska, M.J., Nakamoto, T. Effects of chronic caffeine feeding on the activities of oxygen free radical defense enzymes in the growing rat heart and liver. Experientia 50, 465–468 (1994). https://doi.org/10.1007/BF01920748
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DOI: https://doi.org/10.1007/BF01920748