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Characteristics of HCN Channels and Their Participation in Neuropathic Pain

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Abstract

Neuropathic pain is induced by the injury to nervous systems and characterized by hyperalgesia, allodynia and spontaneous pain. The underlying mechanisms include peripheral and central sensitization resulted from neuronal hyperexcitability. A number of ion channels are considered to contribute to the neuronal hyperexcitability. Here, we particularly concentrate on an interesting ion channel, hyperpolarization-activated cyclic nucleotide gated (HCN) channels. We overview its biophysical properties, physiological functions, followed by focusing on the current progress in the study of its role in the development of neuropathic pain. We attempt to provide a comprehensive review of the potential valuable target, HCN channels, in the treatment of neuropathic pain.

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Acknowledgements

This work was supported by the grants from Beijing Natural Science Foundation (7052039), National Natural Science Foundation of China (30600173, 30570566, 30470559 and 30330230), “111” Project of the Ministry of Education of China and “973” program of the Ministry of Science and Technology of China (2007CB512501).

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  1. Qian Sun

    Present address: Department of Biology, Brandeis University, Waltham, MA, 02454, USA

  2. Hui-Yin Tu

    Present address: Department of Physiology, Basic Medical College of Zhengzhou University, Zhengzhou, 450001, Henan, People’s Republic of China

Authors and Affiliations

  1. Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing, 100083, People’s Republic of China

    Yu-Qiu Jiang, Qian Sun, Hui-Yin Tu & You Wan

  2. Department of Neurobiology, Peking University, Beijing, 100083, People’s Republic of China

    Yu-Qiu Jiang & You Wan

  3. Key Laboratory for Neuroscience, Peking University, Beijing, 100083, People’s Republic of China

    You Wan

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Correspondence to You Wan.

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Special issue article in honor of Dr. Ji-Sheng Han.

Yu-Qiu Jiang, Qian Sun, and Hui-Yin Tu—contributed equally to this paper.

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Jiang, YQ., Sun, Q., Tu, HY. et al. Characteristics of HCN Channels and Their Participation in Neuropathic Pain. Neurochem Res 33, 1979–1989 (2008). https://doi.org/10.1007/s11064-008-9717-6

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