Abstract
Alzheimer’s disease, the most common neurodegenerative disorder of senile dementia, is characterized by two major morpho-pathological hallmarks. Deposition of extracellular neuritic, β-amyloid peptide-containing plaques (senile plaques) in cerebral cortical regions of Alzheimer patients is accompanied by the presence of intracellular neurofibrillary tangles in cerebral pyramidal neurons. Basal forebrain cholinergic dysfunction is also a consistent feature of Alzheimer’s disease, which has been suggested to cause, at least partly, the cognitive deficits observed in patients with Alzheimer’s disease. Impaired cortical cholinergic neurotransmission may also contribute to β-amyloid plaque pathology in Alzheimer’s disease by affecting expression and processing of the β-amyloid precursor protein (APP). Vice versa, low level of soluble β-amyloid has been observed to inhibit cholinergic synaptic function. Deposition of β-amyloid plaques in Alzheimer’s disease is also accompanied by a significant plaque-associated glial up-regulation of interleukin-1, which has been attributed to affect expression and metabolism of APP and to interfere with cholinergic transmission. Understanding the molecular mechanisms underlying the interrelationship between cortical cholinergic dysfunction, β-amyloid formation and deposition, as well as local inflammatory upregulation, would allow to derive potential treatment strategies to pharmacologically intervene in the disease-causing signaling cascade.
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References
A. Nordberg (1992) ArticleTitleNeuroreceptor changes in Alzheimer disease Cerebrovasc. Brain Met. Rev. 4 303–328
L. M. Bierer V. Haroutunian S. Gabriel P. J. Knott L. S. Carlin D. P. Purohit D. P. Perl J. Schmeidler P. Kanof K. L. Davis (1995) ArticleTitleNeurochemical correlates of dementia severity in Alzheimer’s disease: relative importance of the cholinergic deficits J. Neurochem. 64 749–760 Occurrence Handle7830069
M. Mesulam (2004) ArticleTitleThe cholinergic lesion of Alzheimer’s disease: pivotal factor or side show Learn Mem. 11 43–49 Occurrence Handle10.1101/lm.69204 Occurrence Handle14747516
D. J. Selkoe (2003) ArticleTitleAging, amyloid, and Alzheimer’s disease: a perspective in honor of Carl Cotman Neurochem. Res. 28 1705–1713 Occurrence Handle10.1023/A:1026065122854 Occurrence Handle14584824
M. M. Mesulam (1986) ArticleTitleAlzheimer plaques and cortical cholinergic innervation Neuroscience 17 275–276 Occurrence Handle10.1016/0306-4522(86)90242-3 Occurrence Handle3960313
M. A. Moran E. J. Mufson P. Gomez-Ramos (1993) ArticleTitleColocalization of cholinesterases with β-amyloid protein in aged and Alzheimer’s brain Acta Neuropathol. 85 362–369 Occurrence Handle10.1007/BF00334445 Occurrence Handle8480510
D. K. Lahiri M. R. Farlow J. J., Nurnberger SuffixJr N. H. Greig (1997) ArticleTitleEffects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures Ann. NY Acad. Sci. 826 416–421 Occurrence Handle9329715
F. Mori C. C. Lai F. Fusi E. Giacobini (1995) ArticleTitleCholinesterase inhibitors increase secretion of APPs in rat brain cortex Neuroreport 6 633–636 Occurrence Handle7605915
M. Racchi M. Sironi A. Caprera G. Konig S. Govoni (2001) ArticleTitleShort- and long-term effect of acetylcholinesterase inhibition on the expression and metabolism of the amyloid precursor protein Mol. Psych. 6 520–528 Occurrence Handle10.1038/sj.mp.4000878
N. C. Inestrosa A. Alvarez C. A. Perez R. D. Moreno M. Vicente C. Linker O. I. Casanueva J. Soto-Garrido (1996) ArticleTitleAcetylcholinesterase accelerates assembly of amyloid-β peptides into Alzheimer’s fibrils: possible role of the peripheral site of the enzyme Neuron 16 881–891 Occurrence Handle10.1016/S0896-6273(00)80108-7 Occurrence Handle8608006
X. Zhang (2004) ArticleTitleCholinergic activity and amyloid precursor protein processing in aging and Alzheimer’s disease Curr. Drug Targets 3 137–152 Occurrence Handle10.2174/1568007043482499 Occurrence Handle15078189
M. Racchi S. Govoni (2003) ArticleTitleThe pharmacology of amyloid precursor protein processing Exp. Gerontol. 38 145–157 Occurrence Handle10.1016/S0531-5565(02)00158-4 Occurrence Handle12543272
A. Alvarez C. Opazo R. Alarcon J. Garrido N. C. Inestrosa (1997) ArticleTitleAcetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils J. Mol. Biol. 272 348–361 Occurrence Handle10.1006/jmbi.1997.1245 Occurrence Handle9325095
M. Bartolini C. Bertucci V. Cavrini V. Andrisano (2003) ArticleTitleβ-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies Biochem Pharmacol. 65 407–416 Occurrence Handle10.1016/S0006-2952(02)01514-9 Occurrence Handle12527333
A. Alvarez R. Alarcon C. Opazo E. O. Campos F. J. Munoz F. H. Calderon F. Dajas M. K. Gentry B. P. Doctor F. G. Mello ParticleDe N. C. Inestrosa (1998) ArticleTitleStable complexes involving acetylcholinesterase and amyloid-β peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer’s fibrils J. Neurosci. 18 3213–3223 Occurrence Handle9547230
A. E. Reyes M. A. Chacon M. C. Dinamarca W. Cerpa C. Morgan N. C. Inestrosa (2004) ArticleTitleAcetylcholinesterase-Aβ complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss Am. J. Pathol. 164 2163–2174 Occurrence Handle15161650
C. Geula M. Mesulam (1989) ArticleTitleSpecial properties of cholinesterases in the cerebral cortex of Alzheimer’s disease Brain Res. 498 185–189 Occurrence Handle10.1016/0006-8993(89)90419-8 Occurrence Handle2790472
C. R. Schatz C. Geula M. Mesulam (1990) ArticleTitleCompetitive substrate inhibition in the histochemistry of cholinesterase activity in Alzheimer’s disease Neurosci. Lett. 117 56–61 Occurrence Handle10.1016/0304-3940(90)90119-T Occurrence Handle2290622
T. Rees P. I. Hammond H. Soreq S. Younkin S. Brimijoin (2003) ArticleTitleAcetylcholinesterase promotes beta-amyloid plaques in cerebral cortex Neurobiol. Aging 24 777–787
N. C. Inestrosa R. Alarcon (1998) ArticleTitleMolecular interactions of acetylcholinesterase with senile plaques J. Physiol. (Paris) 92 341–344 Occurrence Handle10.1016/S0928-4257(99)80002-3
A. E. Reyes D. R. Perez A. Alvarez J. Garrido M. K. Gentry B. P. Doctor N. C. Inestrosa (1997) ArticleTitleA monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme Biochem. Biophys. Res. Commun. 232 652–655 Occurrence Handle10.1006/bbrc.1997.6357 Occurrence Handle9126330
R. A. Fuentealba G. Farias J. Scheu M. Bronfman M. P. Marzolo N. C. Inestrosa (2004) ArticleTitleSignal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease Brain Res. Rev. 47 275–289 Occurrence Handle10.1016/j.brainresrev.2004.07.018 Occurrence Handle15572177
G. Sberna J. Saez-Valero K. Beyreuther C. L. Masters D. H. Small (1997) ArticleTitleThe amyloid beta-protein of Alzheimer’s disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells J. Neurochem. 69 1177–1184 Occurrence Handle9282941
J. Saez-Valero L. R. Fodero A. R. White C. J. Barrow D. H. Small (2003) ArticleTitleAcetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with beta-amyloid peptides Brain Res. 965 283–286 Occurrence Handle10.1016/S0006-8993(02)04159-8 Occurrence Handle12591148
L. R. Fodero S. S. Mok D. Losic L. L. Martin M. I. Aguilar C. J. Barrow B. G. Livett D. H. Small (2004) ArticleTitleα7-nicotinic acetylcholine receptors mediate an Aβ(1–42)-induced increase in the level of acetylcholinesterase in primary cortical neurones J. Neurochem. 88 1186–1193 Occurrence Handle10.1046/j.1471-4159.2003.02296.x Occurrence Handle15009674
R. M. Nitsch B. E. Slack R. J. Wurtman J. H. Growdon (1992) ArticleTitleRelease of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors Science 258 304–307 Occurrence Handle1411529
R. M. Nitsch S.A. Farber J.H. Growdon R.J. Wurtman (1993) ArticleTitleRelease of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices Proc. Natl. Acad. Sci. USA. 90 5191–5193 Occurrence Handle8506366
H. A. Ensinger H. N. Doods A. R. Immel-Sehr F. J. Kuhn G. Lambrecht K. D. Mendla R. E. Muller E. Mutschler A. Sagrada G. Walther et al. (1993) ArticleTitleWAL 2014 – a muscarinic agonist with preferential neuron-stimulating properties Life Sci. 52 473–480 Occurrence Handle10.1016/0024-3205(93)90304-L Occurrence Handle8441328
S. A. Farber R. M. Nitsch J. G. Schulz R. J. Wurtman (1995) ArticleTitleRegulated secretion of β-amyloid precursor protein in rat brain J. Neurosci. 15 7442–7451 Occurrence Handle7472496
A. Walland S. Burkard R. Hammer W. Troger (1997) ArticleTitleIn vivo consequences of M1-receptor activation by talsaclidine Life Sci. 60 977–984 Occurrence Handle10.1016/S0024-3205(97)00037-4 Occurrence Handle9121364
D. M. Müller K. Mendla S. A. Farber R. M. Nitsch (1997) ArticleTitleMuscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain Life Sci. 60 985–991 Occurrence Handle10.1016/S0024-3205(97)00038-6 Occurrence Handle9121365
C. Hock A. Maddalena A. Raschig F. Muller-Spahn G. Eschweiler K. Hager I. Heuser H. Hampel T. Muller-Thomsen W. Oertel M. Wienrich A. Signorell C. Gonzalez-Agosti R. M. Nitsch (2003) ArticleTitleTreatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of Aβ42 in patients with Alzheimer’s disease Amyloid 10 1–6 Occurrence Handle12762134
R. M. Nitsch M. Deng M. Tennis D. Schoenfeld J. H. Growdon (2002) ArticleTitleThe selective muscarinic agonist AF102B decreases levels of total Ab in CSF of patients with Alzheimer’s disease Ann. Neurol. 48 913–918 Occurrence Handle10.1002/1531-8249(200012)48:6<913::AID-ANA12>3.0.CO;2-S
A. Y. Hung C. Haass R. M. Nitsch W. Q. Qiu M. Citron R. J. Wurtman J. H. Growdon D. J. Selkoe (1993) ArticleTitleActivation of protein kinase C inhibits cellular production of the amyloid beta-protein J. Biol. Chem. 268 22959–22962 Occurrence Handle8226807
B. E. Slack J Breu M. A. Petryniak K. Srivastava R. J. Wurtman (1995) ArticleTitleTyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor J. Biol. Chem. 270 8337–8344 Occurrence Handle10.1074/jbc.270.14.8337 Occurrence Handle7713942
R. Haring A. Fisher D. Marciano Z. Pittel Y. Kloog A. Zuckerman N. Eshhar E. Heldman (1998) ArticleTitleMitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to beta-amyloid precursor protein secretion J. Neurochem. 71 2094–2103 Occurrence Handle9798935
B. E. Slack (2000) ArticleTitleThe m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase Biochem. J. 348 IssueIDPt 2 381–387 Occurrence Handle10.1042/0264-6021:3480381 Occurrence Handle10816433
S. Roßner U. Ueberham R. Schliebs J. R. Perez-Polo V. Bigl (1998) ArticleTitleThe regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling Prog. Neurobiol. 56 541–569 Occurrence Handle10.1016/S0301-0082(98)00044-6 Occurrence Handle9775403
L. Lin B. Georgievska A. Mattsson O. Isacson (1999) ArticleTitleCognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation Proc. Natl. Acad. Sci. USA 96 12108–12113 Occurrence Handle10.1073/pnas.96.21.12108 Occurrence Handle10518584
H. Seo A. W. Ferree O. Isacson (2002) ArticleTitleCortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice Eur. J. Neurosci. 15 498–505 Occurrence Handle10.1046/j.0953-816x.2001.01884.x Occurrence Handle11876777
R. M. Canet-Aviles M. Anderton N. M. Hooper A. J. Turner P. F. Vaughan (2002) ArticleTitleMuscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C Mol. Brain Res. 102 62–72 Occurrence Handle10.1016/S0169-328X(02)00184-5 Occurrence Handle12191495
T. Zuechner J. R. Perez-Polo R. Schliebs (2004) ArticleTitleβ-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling J. Neurosci. Res. 77 250–257 Occurrence Handle10.1002/jnr.20152 Occurrence Handle15211591
S. Efthimiopoulos D. Vassilacopoulou J. A. Ripellino N. Tezapsidis N. K. Robakis (1996) ArticleTitleCholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells Proc. Natl. Acad. Sci. USA 93 8046–8050 Occurrence Handle10.1073/pnas.93.15.8046 Occurrence Handle8755600
J. Seo S. Kim H. Kim C. H. Park S. Jeong J. Lee S. H. Choi K. Chang J. Rah J. Koo E. Kim Y. Suh (2001) ArticleTitleEffects of nicotine on APP secretion and Aβ- or CT(105)-induced toxicity Biol. Psych. 49 240–247 Occurrence Handle10.1016/S0006-3223(00)01124-0
T. Utsuki M. Shoaib H. W. Holloway D. K. Ingram W. C. Wallace V. Haroutunian K. Sambamurti D. K. Lahiri N. H. Greig (2002) ArticleTitleNicotine lowers the secretion of the Alzheimer’s amyloid β-protein precursor that contains amyloid β-peptide in rat J. Alzheimers Dis. 4 405–415 Occurrence Handle12446972
D. K. Lahiri T. Utsuki D. Chen M. R. Farlow M. Shoaib D. K. Ingram N. H. Greig (2002) ArticleTitleNicotine reduces the secretion of Alzheimer’s β-amyloid precursor protein containing β-amyloid peptide in the rat without altering synaptic proteins Ann. NY Acad. Sci. 965 364–372 Occurrence Handle12105112
A. R. Salomon K. J. Marcinowski R. P. Friedland M. G. Zagorski (1996) ArticleTitleNicotine inhibits amyloid formation by the β-peptide Biochemistry. 35 13568–13578 Occurrence Handle10.1021/bi9617264 Occurrence Handle8885836
K. Ono K. Hasegawa M. Yamada H. Naiki (2002) ArticleTitleNicotine breaks down preformed Alzheimer’s β-amyloid fibrils in vitro Biol. Psychiatry. 52 880–886 Occurrence Handle10.1016/S0006-3223(02)01417-8 Occurrence Handle12399141
A. Nordberg E. Hellström-Lindahl M. Lee M. Johnson M Mousavi R. . Hall E. Perry I. Bednar J. Court (2002) ArticleTitleChronic nicotine treatment reduces b-amyloidosis in the brain of mouse model of Alzheimer’s disease (APPsw) J. Neurochem. 81 655–658 Occurrence Handle10.1046/j.1471-4159.2002.00874.x Occurrence Handle12065674
E. Hellstrom-Lindahl J. Court J. Keverne M. Svedberg M. Lee A. Marutle A. Thomas E. Perry I. Bednar A. Nordberg (2004) ArticleTitleNicotine reduces Aβ in the brain and cerebral vessels of APPsw mice Eur. J. Neurosci. 19 2703–2710 Occurrence Handle10.1111/j.0953-816X.2004.03377.x Occurrence Handle15147304
E. J. Mufson E. Y. Chen E. J. Cochran L. A. Beckett D. A. Bennett J. H. Kordower (1999) ArticleTitleEntorhinal cortex β-amyloid load in individuals with mild cognitive impairment Exp. Neurol. 158 469–490 Occurrence Handle10.1006/exnr.1999.7086 Occurrence Handle10415154
T. Harkany S. O’Mahony J. P. Kelly K. Soos I. Toro B. Penke P. G. Luiten C. Nyakas K. Gulya B. E. Leonhard (1998) ArticleTitleβ-amyloid (Phe(SO3H)24)25–35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation Behav. Brain Res. 90 133–145 Occurrence Handle10.1016/S0166-4328(97)00091-0 Occurrence Handle9580273
S. O’Mahony T. Harkany A. A. M. Rensink I. Abraham G. I. DeJong J. L. Varga M. Zarandi B. Penke C. Nyakas P. G. M. Luiten B. E. Leonhard (1998) ArticleTitleβ-Amyloid-induced cholinergic denervation correlates with enhanced nitric oxide synthase activity in rat cerebral cortex: reversal by NMDA receptor blockade Brain Res. Bull. 45 405–411 Occurrence Handle10.1016/S0361-9230(97)00405-X Occurrence Handle9527015
T. Harkany J. Mulder M. Sasvari I. Abraham C. Konya M. Zarandi B. Penke P. G. Luiten C. Nyakas (1999) ArticleTitleN-methyl-D-aspartate receptor antagonist MK-801 and radical scavengers protect cholinergic nucleus basalis neuron against β-amyloid neurotoxicity Neurobiol. Dis. 6 109–221 Occurrence Handle10.1006/nbdi.1998.0230 Occurrence Handle10343326
T. Harkany I. Abraham W. Timmermann G. Laskay B. Toth M. Sasvari C. Konya J. B. Sebens J. Korf C. Nyakas M. Zarandi K. Soos B. Penk P. G. Luiten (2000) ArticleTitleβ-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis Eur. J. Neurosci. 12 2735–2745 Occurrence Handle10.1046/j.1460-9568.2000.00164.x Occurrence Handle10971616
T. Harkany I. Abraham C. Konya C. Nyakas M. Zarandim B. Penke P. G. Luiten (2000) ArticleTitleMechanisms of β-amyloid neurotoxicity: perspectives of pharmacotherapy Rev. Neurosci. 11 329–382 Occurrence Handle11065280
W. T. Kimberly M. J. LaVoie B. L. Ostaszewski W. Ye M. S. Wolfe D. J. Selkoe (2003) ArticleTitleγ-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2 Proc. Natl. Acad. Sci. USA 100 6382–6387 Occurrence Handle10.1073/pnas.1037392100 Occurrence Handle12740439
J. T. Gau M. L. Steinhilb T. C. Kao C. J. D’Amato J. R. Gaut K. A. Frey R. S. Turner (2002) ArticleTitleStable β-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 mice Am. J. Pathol. 160 731–738 Occurrence Handle11839594
D. Hernandez K. Sugaya T. Qu E. McGowan K. Duff M. McKinney (2001) ArticleTitleSurvival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes Neuroreport 12 1377–1384 Occurrence Handle10.1097/00001756-200105250-00018 Occurrence Handle11388415
L. Hu T. P. Wong S. L. Cote K. F. Bell A. C. Cuello (2003) ArticleTitleThe impact of Aβ-plaques on cortical cholinergic and non-cholinergic presynaptic boutons in alzheimer’s disease-like transgenic mice Neuroscience 121 421–432 Occurrence Handle10.1016/S0306-4522(03)00394-4 Occurrence Handle14522000
D. C. German U. Yazdani S. G. Speciale P. Pasbakhsh D. Games C. L. Liang (2003) ArticleTitleCholinergic neuropathology in a mouse model of Alzheimer’s disease J. Comp. Neurol. 462 371–381 Occurrence Handle10.1002/cne.10737 Occurrence Handle12811807
F. C. Bronfman D. Moechars F. Leuven ParticleVan (2000) ArticleTitleAcetylcholine-positive fibre deafferentation and cell shrinkage in the septohippocampal pathway of aged amyloid precursor protein London mutant transgenic mice Neurobiol. Dis. 7 152–168 Occurrence Handle10.1006/nbdi.2000.0283 Occurrence Handle10860782
S. Boncristiano M. E. Calhoun P. H. Kelly M. Pfeifer L. Bondolfi M. Stalder A. L. Phinney D. Abramowski C. Sturchler-Pierrat A. Enz B. Sommer M. Staufenbiel M. Jucker (2002) ArticleTitleCholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis J. Neurosci. 22 3234–3243 Occurrence Handle11943824
S. Jaffar S. E. Counts S. Y. Ma E. Dadko M. N. Gordon D. Morgan E. J. Mufson. (2001) ArticleTitleNeuropathology of mice carrying mutant APPSWE and/or PS1M146L transgenes: Alterations in the p75NTR cholinergic basal forebrain septohippocampal pathway Exp. Neurol. 170 227–243 Occurrence Handle10.1006/exnr.2001.7710 Occurrence Handle11476589
T. P. Wong T. Debeir K. Duff A. C. Cuello (1999) ArticleTitleReorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes J. Neurosci. 19 2706–2716 Occurrence Handle10087083
J. Hartmann C. Erb U. Ebert K. H. Baumann A. Popp G. König J. Klein (2004) ArticleTitleCentral cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice Neuroscience 125 1009–1017 Occurrence Handle10.1016/j.neuroscience.2004.02.038 Occurrence Handle15120860
J. Apelt A. Kumar R. Schliebs (2002) ArticleTitleImpairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human β-amyloid precursor protein Brain Res. 953 17–30 Occurrence Handle10.1016/S0006-8993(02)03262-6 Occurrence Handle12384234
H. J. Lüth J. Apelt A. Ihunwo R. Schliebs (2003) ArticleTitleDegeneration of β-amyloid-associated cholinergic structures in transgenic APPSW mice Brain Res. 977 IssueID2003 16–22 Occurrence Handle10.1016/S0006-8993(03)02658-1 Occurrence Handle12788508
M. Klingner J. Apelt A. Kumar D. Sorger O. Sabri J. Steinbach M. Scheunemann R. Schliebs (2003) ArticleTitleAlterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with β-amyloid plaque pathology Int. J. Devl. Neurosci. 21 357–369 Occurrence Handle10.1016/j.ijdevneu.2003.08.001
C. Haass D. J. Selkoe (1993) ArticleTitleCellular processing of β-amyloid precursor protein and the genesis of amyloid beta-peptide Cell 75 1039–1042 Occurrence Handle10.1016/0092-8674(93)90312-E Occurrence Handle8261505
M. Shoji T. E. Golde J. Ghiso T. T. Cheung S. Estus L. M. Shaffer X. D. Cai D. M. McKay R. Tintner B. Frangione (1992) ArticleTitleProduction of the Alzheimer amyloid beta protein by normal proteolytic processing Science 258 126–129 Occurrence Handle1439760
D. S. Auld T. J. Kornecook S. Bastianetto R. Quirion (2002) ArticleTitleAlzheimer’s disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies Prog. Neurobiol. 68 209–245 Occurrence Handle10.1016/S0301-0082(02)00079-5 Occurrence Handle12450488
S. Kar S. P. Slowikowski D. Westaway H. T. Mount (2004) ArticleTitleInteractions between β-amyloid and central cholinergic neurons: implications for Alzheimer’s disease J. Psych. Neurosci. 29 427–441
W. A. Pedersen M. A. Kloczewiak J. K. Blusztajn (1996) ArticleTitleAmyloid β-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain Proc. Natl. Acad. Sci. USA 93 8068–8071 Occurrence Handle10.1073/pnas.93.15.8068 Occurrence Handle8755604
M. Hoshi A. Takashima M. Murayama K. Yasutake N. Yoshida K. Ishiguro T. Hoshino K. Imahori (1997) ArticleTitleNontoxic amyloid β peptide 1–42 suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer’s disease J. Biol. Chem. 272 2038–2041 Occurrence Handle10.1074/jbc.272.4.2038 Occurrence Handle8999897
J. F. Kelly K. Furukawa S. W. Barger M. R. Rengen R. J. Mark E. M. Blanc G. S. Roth M. P. Mattson (1996) ArticleTitleAmyloid β-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons Proc. Natl. Acad. Sci. USA 93 6753–6758 Occurrence Handle10.1073/pnas.93.13.6753 Occurrence Handle8692890
Z. Z. Guan H. Miao J. Y. Tian C. Unger A. Nordberg X. Zhang (2001) ArticleTitleSuppressed expression of nicotinic acetylcholine receptors by nanomolar β-amyloid peptides in PC12 cells J. Neural. Transm. 108 1417–1433 Occurrence Handle10.1007/s007020100017 Occurrence Handle11810405
Q. Liu H. Kawai D. K. Berg (2001) ArticleTitleβ-amyloid peptide blocks the response of α7-containing nicotinic receptors on hippocampal neurons Proc. Natl. Acad. Sci. USA 98 4734–4739 Occurrence Handle10.1073/pnas.081553598 Occurrence Handle11274373
T. Teaktong A. J. Graham J. A. Court R. H. Perry E. Jaros M. Johnson R. Hall E. K. Perry (2004) ArticleTitleNicotinic acetylcholine receptor immunohistochemistry in Alzheimer’s disease and dementia with Lewy bodies; differential and astroglial pathology J. Neurol. Sci. 225 39–49 Occurrence Handle10.1016/j.jns.2004.06.015 Occurrence Handle15465084
H. Y. Wang D. H. Lee M. R. D’Andrea P. A. Peterson R. P. Shank A. B. Reitz (2000) ArticleTitleβ-Amyloid(1–42) binds to α7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer’s disease pathology J. Biol. Chem. 275 5626–5632 Occurrence Handle10.1074/jbc.275.8.5626 Occurrence Handle10681545
H. Y. Wang D. H. Lee C. B. Davis R. P. Shank (2000) ArticleTitleAmyloid peptide Aβ (1–42) binds selectively and with picomolar affinity to α7 nicotinic acetylcholine receptors J. Neurochem. 75 1155–1161 Occurrence Handle10.1046/j.1471-4159.2000.0751155.x Occurrence Handle10936198
Z. Z. Guan W. F. Yu K. R. Shan T. Nordman J. Olsson A. Nordberg (2003) ArticleTitleLoss of nicotinic receptors induced by β-amyloid peptides in PC12 cells: possible mechanism involving lipid peroxidation J. Neurosci. Res. 71 397–406 Occurrence Handle10.1002/jnr.10496 Occurrence Handle12526028
K. T. Dineley M. Westerman D. Bui K. Bell K. H. Ashe J. D. Sweatt (2001) ArticleTitleβ-amyloid activates the mitogen-activated protein kinase cascade via hippocampal α7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer’s disease J. Neurosci. 21 4125–4133 Occurrence Handle11404397
K. T. Dineley K. A. Bell D. Bui J. D. Sweatt (2002) ArticleTitleβ-Amyloid peptide activates α7 nicotinic acetylcholine receptors expressed in Xenopus oocytes J. Biol. Chem. 277 25056–250561 Occurrence Handle10.1074/jbc.M200066200 Occurrence Handle11983690
D. L. Pettit Z. Shao J. L. Yakel (2001) ArticleTitleβ-amyloid (1–42) peptide directly modulates nicotinic receptors in the rat hippocampal slice J. Neurosci. 21 RC120 Occurrence Handle11150356
H. Tozaki A. Matsumoto T. Kanno K. Nagai T. Nagata I. Yamamoto T. Nishizaki (2002) ArticleTitleThe inhibitory and facilitatory actions of amyloid-β peptides on nicotinic Ach receptors and AMPA receptors Biochem. Biophys. Res. Commun. 294 42–45 Occurrence Handle10.1016/S0006-291X(02)00429-1 Occurrence Handle12054737
F. Grassi E. Palma R. Tonini M. Amici M. Ballivet F. Eusebi (2003) ArticleTitleAmyloid β (1–42) peptide alters the gating of human and mouse α-bungarotoxin-sensitive nicotinic receptors J. Physiol. 547 IssueIDPt 1 147–57 Occurrence Handle10.1113/jphysiol.2002.035436 Occurrence Handle12562926
D. H. Lee H. Y. Wang (2003) ArticleTitleDifferential physiologic responses of α7 nicotinic acetylcholine receptors to β-amyloid1–40 and β-amyloid1–42 J. Neurobiol. 55 25–30 Occurrence Handle10.1002/neu.10203 Occurrence Handle12605456
J. K. Blusztajn B. Berse (2000) ArticleTitleThe cholinergic neuronal phenotype in Alzheimer’s disease Metab. Brain Dis. 15 45–64 Occurrence Handle10.1023/A:1011161718572 Occurrence Handle10885540
T. G. Beach Y. M. Kuo K. Spiegel M. R. Emmerling L. I. Sue K. Kokjohn A. E. Roher (2000) ArticleTitleThe cholinergic deficit coincides with Abeta deposition at the earliest histopathologic stages of Alzheimer disease J. Neuropathol. Exp. Neurol. 59 308–313 Occurrence Handle10759186
M. Cacquevel N. Lebeurrier S. Cheenne D. Vivien (2004) ArticleTitleCytokines in neuroinflammation and Alzheimer’s disease Curr. Drug Targets. 5 529–534 Occurrence Handle10.2174/1389450043345308 Occurrence Handle15270199
P. Eikelenboom W. A. Gool Particlevan (2004) ArticleTitleNeuroinflammatory perspectives on the two faces of Alzheimer’s disease J.␣Neural Transm. 111 281–294 Occurrence Handle10.1007/s00702-003-0055-1 Occurrence Handle14991455
J. Apelt R. Schliebs (2001) ArticleTitleβ-Amyloid-induced glial expression of both pro-and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology Brain Res. 894 21–30 Occurrence Handle10.1016/S0006-8993(00)03176-0 Occurrence Handle11245811
W. C. Benzing J. R. Wujek E. K. Ward D. Shaffer K. H. Ashe S. G. Younkin K. R. Brunden (1999) ArticleTitleEvidence for glial-mediated inflammation in aged APP(SW) transgenic mice Neurobiol. Aging 20 581–589 Occurrence Handle10.1016/S0197-4580(99)00065-2 Occurrence Handle10674423
M. N. Gordon L. A. Holcomb P. T. Jantzen G. DiCarlo D. Wilcock K. W. Boyett K. Connor J. Melachrino J. P. O’Callaghan D. Morgan (2002) ArticleTitleTime course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse Exp. Neurol. 173 183–195 Occurrence Handle10.1006/exnr.2001.7754 Occurrence Handle11822882
G. L. Wenk L. B. Willard (1998) ArticleTitleThe neuronal mechanisms underlying cholinergic cell death within the basal forebrain Int. J. Dev. Neurosci. 16 729–735 Occurrence Handle10.1016/S0736-5748(98)00081-1 Occurrence Handle10198820
L. B. Willard B. Hauss-Wegrzyniak G. L. Wenk (1999) ArticleTitlePathological and biochemical consequences of acute and chronic neuroinflammation within the basal forebrain cholinergic system of rats Neuroscience 88 193–200 Occurrence Handle10.1016/S0306-4522(98)00216-4 Occurrence Handle10051200
G. L. Wenk K. McGann A. Mencarelli B. Hauss-Wegrzyniak P. DelSoldato S. Fiorucci (2000) ArticleTitleMechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons Eur. J. Pharmacol. 402 77–85 Occurrence Handle10.1016/S0014-2999(00)00523-9 Occurrence Handle10940360
M. McMillian L. Y. Kong S. M. Sawin B. Wilson K. Das P. Hudson J. S. Hong G. Bing (1995) ArticleTitleSelective killing of cholinergic neurons by microglial activation in basal forebrain mixed neuronal/glial cultures Biochem. Biophys. Res. Commun. 215 572–577 Occurrence Handle10.1006/bbrc.1995.2503 Occurrence Handle7487994
L. B. Willard B. Hauss-Wegrzyniak W. Danysz G. L. Wenk (2000) ArticleTitleThe cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition Exp. Brain Res. 134 58–65 Occurrence Handle10.1007/s002210000446 Occurrence Handle11026726
G. L. Wenk K. McGann B. Hauss-Wegrzyniak S. Rosi (2003) ArticleTitleThe toxicity of tumor necrosis factor-alpha upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for Alzheimer’s disease Neuroscience 121 719–729 Occurrence Handle10.1016/S0306-4522(03)00545-1 Occurrence Handle14568031
G. L. Wenk K. McGann-Gramling B. Hauss-Wegrzyniak (2004) ArticleTitleThe presence of the APP (swe) mutation in mice does not increase the vulnerability of cholinergic basal forebrain neurons to neuroinflammation Neuroscience 125 769–776 Occurrence Handle10.1016/j.neuroscience.2004.01.050 Occurrence Handle15099690
R. D. Shytle T. Mori K. Townsend M. Vendrame N. Sun J. Zeng J. Ehrhart A. A. Silver P. R. Sanberg J. Tan (2004) ArticleTitleCholinergic modulation of microglial activation by α7 nicotinic receptors J. Neurochem. 89 337–343 Occurrence Handle15056277
B. Brugg Y. L. Dubreuil G. Huber E. E. Wollman N. Delhaye-Bouchaud J. Mariani (1995) ArticleTitleInflammatory processes induces β-amyloid precursor protein changes in mouse brain Proc. Natl. Acad. Sci. USA 92 3032–3035 Occurrence Handle7708769
J. D. Buxbaum M. Oishi H. I. Chen R. Pinkas-Kramarski E. A. Jaffe S. E. Gandy P. Greengard (1992) ArticleTitleCholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor Proc. Natl. Acad. Sci. USA 89 10075–10078 Occurrence Handle1359534
G. Forloni F. Demicheli S. Giorgi C. Bendotti N. Angeretti (1992) ArticleTitleExpression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1 Mol. Brain Res. 16 128–134 Occurrence Handle10.1016/0169-328X(92)90202-M Occurrence Handle1334190
D. Goldgaber M. I. Lerman O. W. McBride U. Saffiotti D. C. Gajdusek (1987) ArticleTitleCharacterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer’s disease Science 235 877–880 Occurrence Handle3810169
J. T. Rogers L. M. Leiter J. McPhee C. M. Cahill S. S. Zhan H. Potter L. N. Nilsson (1999) ArticleTitleTranslation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5’-untranslated region sequences J.␣Biol. Chem. 274 6421–6431 Occurrence Handle10.1074/jbc.274.10.6421 Occurrence Handle10037734
J. G. Sheng S. G. Zhu R. A. Jones W. S. Griffin R. E. Mrak (2000) ArticleTitleInterleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo Exp. Neurol. 163 388–391 Occurrence Handle10.1006/exnr.2000.7393 Occurrence Handle10833312
J. G. Sheng W. S. Griffin M. C. Royston R. E. Mrak (1998) ArticleTitleDistribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer’s disease Neuropathol. Appl. Neurobiol. 24 278–283 Occurrence Handle10.1046/j.1365-2990.1998.00122.x Occurrence Handle9775393
Y. Li L. Liu J. Kang J. G. Sheng S. W. Barger R. E. Mrak W. S. T. Griffin (2000) ArticleTitleNeuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression J. Neurosci. 20 149–155 Occurrence Handle10627591
M. Hartlage-Rübsamen U. Zeitschel J. Apelt U. Gärtner H. Franke T. Stahl A. Günther R. Schliebs M. Penkowa V. Bigl S. Roßner (2003) ArticleTitleAstrocytic expression of the Alzheimer’s disease β-secretase (BACE1) is stimulus-dependent Glia 41 169–179 Occurrence Handle10.1002/glia.10178 Occurrence Handle12509807
S. Roßner J. Apelt R. Schliebs J. R. Perez-Polo V. Bigl (2001) ArticleTitleNeuronal and glial β-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology J. Neurosci. Res. 64 437–446 Occurrence Handle10.1002/jnr.1095 Occurrence Handle11391698
S. Roßner G. Mehlhorn R. Schliebs V. Bigl (2001) ArticleTitleIncreased neuronal and glial expression of protein kinase C isoforms in neocortex of transgenic Tg2576 mice with amyloid pathology Eur. J. Neurosci. 13 269–278 Occurrence Handle10.1046/j.1460-9568.2001.01388.x Occurrence Handle11168531
T. Wyss-Coray J.D. Loike T. C. Brionne E. Lu R. Anankov F. Yan S. C. Silverstein J. Husemann (2003) ArticleTitleAdult mouse astrocytes degrade amyloid-β in vitro and in situ Nat. Med. 9 453–457 Occurrence Handle10.1038/nm838 Occurrence Handle12612547
J. Apelt K. Ach R. Schliebs (2003) ArticleTitleAging-related down-regulation of neprilysin, a putative β-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of β-amyloid plaques Neurosci. Lett. 339 183–186 Occurrence Handle10.1016/S0304-3940(03)00030-2 Occurrence Handle12633883
R. Hellweg C. A. Gericke K. Jendroska H. D. Hartung J. Cervos-Navarro (1998) ArticleTitleNGF content in the cerebral cortex of non-demented patients with amyloid-plaques and in symptomatic Alzheimer’s disease Int. J. Dev. Neurosci. 16 787–794 Occurrence Handle10.1016/S0736-5748(98)00088-4 Occurrence Handle10198825
R. Katoh-Semba R. Semba I. K. Takeuchi K. Kato (1998) ArticleTitleAge-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3 Neurosci. Res. 31 227–234 Occurrence Handle10.1016/S0168-0102(98)00040-6 Occurrence Handle9809668
K. Murase T. Nabeshima Y. Robitaille R. Quirion M. Ogawa K. Hayashi (1993) ArticleTitleNGF level of is not decreased in the serum, brain-spinal fluid, hippocampus, or parietal cortex of individuals with Alzheimer’s disease Biochem. Biophys. Res. Commun. 193 198–203 Occurrence Handle10.1006/bbrc.1993.1609 Occurrence Handle8503908
M. Narisawa-Saito K. Wakabayashi S. Tsuji H. Takahashi H. Nawa (1996) ArticleTitleRegional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer’s disease Neuroreport 7 2925–2928 Occurrence Handle9116211
J. D. Cooper D. Lindholm M. V. Sofroniew (1994) ArticleTitleReduced transport of 125I-NGF by cholinergic neurons and downregulated TrkA expression in the medial septum of aged rats Neuroscience 62 625–629 Occurrence Handle10.1016/0306-4522(94)90462-6 Occurrence Handle7532836
S. DeLacalle J. D. Cooper C. N. Svendsen S. B. Dunnett M. V. Sofroniew (1996) ArticleTitleReduced retrograde labeling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats Neuroscience 75 19–27 Occurrence Handle10.1016/0306-4522(96)00239-4 Occurrence Handle8923519
M. V. Sofroniew C. L. Howe W. C. Mobley (2001) ArticleTitleNerve growth factor signaling, neuroprotection, and neural repair Annu. Rev. Neurosci. 24 1217–1281 Occurrence Handle10.1146/annurev.neuro.24.1.1217 Occurrence Handle11520933
S. Capsoni G. Ugolini A. Comparini F. Ruberti N. Berardi A. Cattaneo (2000) ArticleTitleAlzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice Proc. Natl. Acad. Sci. USA 97 6826–6831 Occurrence Handle10.1073/pnas.97.12.6826 Occurrence Handle10841577
O. Isacson H. Seo L. Lin D. Albeck A. C. Granholm (2002) ArticleTitleAlzheimer’s disease and Down’s syndrome: roles of APP, trophic factors and Ach Trends Neurosci. 25 79–84 Occurrence Handle10.1016/S0166-2236(02)02037-4 Occurrence Handle11814559
C. Wang R. J. Wurtman R. K. Lee (2000) ArticleTitleAmyloid precursor protein and membrane phospholipids in primary cortical neurons increase with development, or after exposure to nerve growth factor or Aβ(1–40) Brain Res. 865 157–167 Occurrence Handle10.1016/S0006-8993(00)02183-1 Occurrence Handle10821917
S. E. Counts J. J. Lah A. I. Levey (2001) ArticleTitleThe regulation of presenilin-1 by nerve growth factor J. Neurochem. 76 679–89 Occurrence Handle10.1046/j.1471-4159.2001.00014.x Occurrence Handle11158238
W. Araki R. J. Wurtman (1998) ArticleTitleIncreased expression of amyloid precursor protein and amyloid precursor-like protein 2 during trophic factor withdrawal-induced death of neuronal PC12 cells Mol Brain Res. 56 169–177 Occurrence Handle10.1016/S0169-328X(98)00050-3 Occurrence Handle9602112
A. Villa M. J. Larasa A. Pascual (2001) ArticleTitleNerve growth factor modulates the expression and secretion of β-amyloid precursor protein through different mechanisms in PC12 cells J. Neurochem. 77 1077–1084 Occurrence Handle10.1046/j.1471-4159.2001.00315.x Occurrence Handle11359873
S. Capsoni S. Giannotta A. Cattaneo (2002) ArticleTitleb-amyloid plaques in a model for sporadic Alzheimer’s disease based on transgenic anti-nerve growth factor antibodies Mol. Cell Neurosci. 21 15–28 Occurrence Handle10.1006/mcne.2002.1163 Occurrence Handle12359148
R. Haring D. Gurwitz J. Barg R. Pinkas-Kramarski E. Heldman Z. Pittel H. D. Danenberg A. Wengier H. Meshulam D. Marciano et al. (1995) ArticleTitleNGF promotes amyloid precursor protein secretion via muscarinic receptor activation Biochem. Biophys. Res. Commun. 213 15–23 Occurrence Handle10.1006/bbrc.1995.2092 Occurrence Handle7639729
N. B. Chauhan G. J. Siegel (2003) ArticleTitleEffect of PPF and ALCAR on the induction of NGF-and p75-mRNA and on APP processing in Tg2576 brain Neurochem. Int. 43 225–233 Occurrence Handle10.1016/S0197-0186(03)00006-8 Occurrence Handle12689602
N. B. Chauhan G. J. Siegel D. L. Feinstein (2005) ArticleTitlePropentofylline attenuates tau hyperphosphorylation in Alzheimer’s Swedish mutant model Tg2576 Neuropharmacology 48 93–104 Occurrence Handle10.1016/j.neuropharm.2004.09.014 Occurrence Handle15617731
S. Roßner U. Ueberham R. Schliebs J. R. Perez-Polo V. Bigl (1998) ArticleTitleNeurotrophin binding to the p75 neurotrophin receptor is necessary but not sufficient to mediate NGF-effects on APP secretion in PC-12 cells J. Neural Transm., [Suppl.] 53 279–285
A. Salehi J. D. Delcroix D. F. Swaab (2004) ArticleTitleAlzheimer’s disease and NGF signaling J. Neural Transm. 111 323–345 Occurrence Handle10.1007/s00702-003-0091-x Occurrence Handle14991458
S. Rabizadeh C. M. Bitler L. L. Butcher D. E. Bredesen (1994) ArticleTitleExpression of the low-affinity nerve growth factor receptor enhances β-amyloid peptide toxicity Proc. Natl. Acad. Sci. USA 91 10703–1076 Occurrence Handle7938014
M. Yaar S. Zhai R.E. Fine P. B. Eisenhauer B. L. Arble K. B. Stewart B. A. Gilchrest (2002) ArticleTitleAmyloid β binds to trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling J. Biol. Chem. 277 7720–7725 Occurrence Handle10.1074/jbc.M110929200 Occurrence Handle11756426
P. Kuner R. Schubenel C. Hertel (1998) ArticleTitleβ-amyloid binds to p57NTR and activates NFκB in human neuroblastoma cells J. Neurosci. Res. 54 798–804 Occurrence Handle10.1002/(SICI)1097-4547(19981215)54:6<798::AID-JNR7>3.0.CO;2-T Occurrence Handle9856863
G. Perini V. Della-Bianca V. Politi G. Della-Valle I. Dal-Pra F. Rossi U. Armato (2002) ArticleTitleRole of p75 neurotrophin receptor in the neurotoxicity by β-amyloid peptides and synergistic effect of inflammatory cytokines J.␣Exp. Med. 195 907–918 Occurrence Handle10.1084/jem.20011797 Occurrence Handle11927634
Y. Zhang Y. Hong Y. Bounhar M. Blacker X. Roucou O. Tounekti E. Vereker W. J. Bowers H. J. Federoff C. G. Goodyer A. LeBlanc (2003) ArticleTitlep75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity J. Neurosci. 23 7385–7394 Occurrence Handle12917374
A. Salehi M. Ocampo J. Verhaagen D. F. Swaab (2000) ArticleTitleP75 neurotrophin receptor in the nucleus basalis of meynert in relation to age, sex, and Alzheimer’s disease Exp. Neurol. 161 245–258 Occurrence Handle10.1006/exnr.1999.7252 Occurrence Handle10683291
E. J. Mufson S. Y. Ma J. Dills E. J. Cochran S. Leurgans J. Wuu D. A. Bennett S. Jaffar M. L. Gilmor A. I. Levey J. H. Kordower (2002) ArticleTitleLoss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer’s disease J. Comp. Neurol. 443 136–153 Occurrence Handle10.1002/cne.10122 Occurrence Handle11793352
S. E. Counts M. Nadeem J. Wuu S. D. Ginsberg H. U. Saragovi E. J. Mufson (2004) ArticleTitleReduction of cortical trkA but not p75NTR protein in early-stage Alzheimer’s disease Ann. Neurol. 56 520–531 Occurrence Handle10.1002/ana.20233 Occurrence Handle15455399
M. Eriksdotter-Jönhagen A. Nordberg K. Amberla L. Backman T. Ebendal B. Meyerson L. Olson M. Seiger-Shigeta E. Theodorsson M. Vittanen B. Winblad L. O. Wahlund (1998) ArticleTitleIntracerebroventricular infusion of nerve growth factor in three patients with Alzheimer’s disease Dement. Geriatr. Cogn. Disord. 9 246–257 Occurrence Handle10.1159/000017069 Occurrence Handle9701676
J. Winkler G. A. Ramirez L. J. Thal J. J. Waite (2000) ArticleTitleNerve growth factor (NGF) augments cortical and hippocampal cholinergic functioning after p75NGF receptor-mediated deafferentation but impairs inhibitory avoidance and induces fear-related behaviors J. Neurosci. 20 834–844 Occurrence Handle10632613
M. H. Tuszynski (2000) ArticleTitleIntraparenchymal NGF infusions rescue degenerating cholinergic neurons Cell Transplant. 9 629–636 Occurrence Handle11144960
P. Francotte A. Graindorge S. Boverie P. Tullio Particlede B. Pirotte (2004) ArticleTitleNew trends in the design of drugs against Alzheimer’s disease Curr. Med. Chem. 11 1757–1778 Occurrence Handle15279580
J. B. Standridge (2004) ArticleTitlePharmacotherapeutic approaches to the prevention of Alzheimer’s disease Am. J. Geriatr. Pharmacother. 2 119–132 Occurrence Handle10.1016/S1543-5946(04)90017-7 Occurrence Handle15555488
B. Wolozin (2004) ArticleTitleCholesterol, statins and dementia Curr. Opin. Lipidol. 15 667–672 Occurrence Handle10.1097/00041433-200412000-00007 Occurrence Handle15529026
B. Schmitt T. Bernhardt H. J. Moeller I. Heuser L. Frolich (2004) ArticleTitleCombination therapy in Alzheimer’s disease: a review of current evidence CNS Drugs 18 827–844 Occurrence Handle15521788
E. Giacobini (2004) ArticleTitleCholinesterase inhibitors: new roles and therapeutic alternatives Pharmacol. Res. 50 433–440 Occurrence Handle10.1016/j.phrs.2003.11.017 Occurrence Handle15304240
K. T. Shaw T. Utsuki J. Rogers Q. S. Yu K. Sambamurti A. Brossi Y. W. Ge D. K. Lahiri N. H. Greig (2001) ArticleTitlePhenserine regulates translation of beta-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development Proc. Natl. Acad. Sci. USA 98 7605–7610 Occurrence Handle10.1073/pnas.131152998 Occurrence Handle11404470
A. Venti T. Giordano P. Eder A. I. Bush D. K. Lahiri N. H. Greig J. T. Rogers (2004) ArticleTitleThe integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5′-untranslated region Ann. NY Acad. Sci. 1035 34–48 Occurrence Handle10.1196/annals.1332.003 Occurrence Handle15681799
L. J. Morse S. M. Payton G. D. Cuny J. T. Rogers (2004) ArticleTitleFDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein J. Mol. Neurosci. 24 129–136 Occurrence Handle10.1385/JMN:24:1:129 Occurrence Handle15314261
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Schliebs, R. Basal Forebrain Cholinergic Dysfunction in Alzheimer’s Disease – Interrelationship with β-amyloid, Inflammation and Neurotrophin Signaling. Neurochem Res 30, 895–908 (2005). https://doi.org/10.1007/s11064-005-6962-9
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DOI: https://doi.org/10.1007/s11064-005-6962-9