Skip to main content
SpringerLink
Log in

Effects of the blockade of the system of opioid peptides on changes in emotional/behavioral reactions of rats induced by the action of extrahigh-frequency electromagnetic radiation in the norm and under conditions of hypokinetic stress

  • Published:
Neurophysiology Aims and scope

Abstract

We studied the effects of pharmacological blockade (by injections of naloxone) of the system of opioid peptides on changes in emotional/behavioral reactions of rats in the open-field test. These changes were caused by the isolated action of low-intensity electromagnetic radiation (EMR) of extrahigh frequency (EHF) and its combination with experimentally induced hypokinetic stress. We conclude that one of the mechanisms of physiological effects of low-intensity EHF EMR is an increase in the functional activity of the system of regulatory opioid peptides; this results in adaptive modifications of the emotional/behavioral reactions under new conditions of the open-field test and provide an anti-stress effect under conditions of hypokinetic stress.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. N. D. Devyatkov, M. B. Golant, and O.V. Betskii, Millimeter Waves and Their Role in Vital Functions [in Russian], Radio Svyaz’, Moscow (1991).

    Google Scholar 

  2. F. Kaiser, “Coherent oscillations-their role in the interaction of weak ELM-fields with cellular systems,” Neural Network World, 5, 761–762 (1995).

    Google Scholar 

  3. A. B. Gapeyev and N. K. Chemeris, “Effects of uninterrupted and modulated MHF EMR on cells of animals,” Review, Chap. I, “Peculiarities and main hypothesis on mechanisms of biological effect of MHF EMR,” Vestn. Nov. Med. Tekhnol., 6, No. 1, 15–22 (1999).

    Google Scholar 

  4. W. Grundler and F. Keilmann, “Sharp resonances in yeast growth prove nonthermal sensitivity to microwaves,” Physiol. Rev. Lett., 51, No. 13, 1214–1216 (1983).

    Article  Google Scholar 

  5. O. V. Betskii, “Frequency dependence of biological effects in the field of electromagnetic waves: new biological resonances in a millimeter range,” Millimeter Waves Biol. Med., 12, No. 2, 3–5 (1998).

    Google Scholar 

  6. E. N. Chuyan, N. A. Temur’yants, and N. V. Chirskii, “Functional activity of the sympathoadrenal system and behavioral indices of rats: changes induced by millimeter-range electromagnetic radiation,” Neurophysiology, 35, No. 2, 108–117 (2003).

    Article  Google Scholar 

  7. E. N. Chuyan, Neuroimmunoendocrine Mechanisms of Adaptation to the Action of Low-Intensity Extrahigh Frequency Electromagnetic Radiation [in Ukrainian], Doctoral Thesis, Biol. Sci., Kyiv (2004).

  8. Yu. L. Arzumanov, O. V. Betskii, N. D. Devyatkov, and N. N. Lebedev, “The use of millimeter waves in clinical medicine (the latest advances),” in: Collected Lectures of 11 Russian Symposium with International Participation “Millimeter Waves in Biology and Medicine” [in Russian], IRS, Moscow (1997), pp. 9–12.

    Google Scholar 

  9. M. H. Repacholi, “Low-level exposure to radio-frequency electromagnetic fields: health effects and research needs,” Bioelektromagnetics, 1, 1–19 (1998).

    Article  Google Scholar 

  10. Yu. A. Kholodov, Reactions of the Nervous System to Electromagnetic Fields [in Russian], Nauka, Moscow (1975).

    Google Scholar 

  11. V. V. Leshin, “Effects of microwave field on the level of catecholamines in the CNS and on behavior of animals,” Vestn. Nov. Med. Tekhnol., 7, No. 1, 28–30 (2000).

    Google Scholar 

  12. E. A. Kovalenko and N. N. Gurovskii, Hypokinesia [in Russian], Meditsina, Moscow (1980).

    Google Scholar 

  13. A. L. Markel’, “On the estimation of basic characteristics of behavior of rats in the open-field test,” Zh. Vyssh. Nerv. Deyat., 31, No. 2, 301–307 (1981).

    CAS  Google Scholar 

  14. E. V. Koplik, “Method of determination of the index of resistance of rats to emotional stress,” Vestn. Nov. Med. Tekhnol., 9, No. 1, 16–18 (2002).

    Google Scholar 

  15. O. N. Bondarenko and E. B. Manukhina, “Effects of different stress-inducing techniques and adaptation on behavioral and somatic indices in rats,” Byul. Éksp. Biol. Med., 126, No. 8, 157–160 (1999).

    Google Scholar 

  16. E. A. Yumatov, “Central peptidergic mechanisms underlying resistance to emotional stress,” in: Emotional Stress: Theoretical and Clinical Aspects [in Russian], K. V. Sudakov and V. I. Petrov (ed.), Volgograd (1997), pp. 134–138.

  17. J. Bureš, O. Burešova, and J. Hewstone, Technique and Basic Experiments for Studying the Brain and Behavior [Russian translation], Vysshaya Shkola, Moscow (1991).

    Google Scholar 

  18. J. W. Holaday, “Cardiovascular consequences of endogenous opiate antagonism,” Biochem. Pharmacol., 32, No. 4, 573–585 (1983).

    Article  PubMed  CAS  Google Scholar 

  19. A. Goldstein, G. T. Pryor, L. Otis, et al., “On the role of endogenous opioid peptides: Failure of naloxone influence shock escape threshold in the rat,” Life Sc., 18, 599–604 (1976).

    Article  CAS  Google Scholar 

  20. N. N. Lebedeva and T. I. Kotrovskaya, “Experimental and clinical studies in the field of biological effects of millimetre waves,” Millimeter Waves Biol. Med., 15, No. 3, 3–15 (1999).

    Google Scholar 

  21. P. V. Simonov, Emotional Brain. Physiology, Neuroanatomy, and Psychology of Emotions [in Russian], Nauka, Moscow (1981).

    Google Scholar 

  22. A. Yu. Galeeva and D. A. Zhukov, “Effects of emotional stress on behavioral and endocrine indices of rats selected on the opposite ability to active avoidance,” Zh. Vyssh. Nerv. Deyat., 46, No. 5, 929–935 (1996).

    Google Scholar 

  23. V. P. Kulikov, V. I. Kiselev, and I. V. Konev, “Effects of different motor modes, which modulate spontaneous activity, on the behavior of rats,” Zh. Vyssh. Nerv. Deyat., 43, No. 2, 398–405 (1993).

    CAS  Google Scholar 

  24. G. A. Vartanyan and E. S. Petrov, Emotions and Behavior [in Russian], Nauka, Leningrad (1989).

    Google Scholar 

  25. F. Z. Meyerson, “Stress-limiting systems of the organism and their role in the prevention of ischemic damage to the heart,” Byul. Vses. Kardiol. Nauch. Tsentra Akad. Med. Nauk SSSR, No. 1, 34–43 (1985).

  26. Yu. B. Lishmanov and L. N. Maslov, “Opioid receptors and resistivity of the heart to arrhythmogenic influences,” Byul. Éksp. Biol. Med., 138, No. 3, 124–131 (2004).

    Google Scholar 

  27. S. Andersson and T. Lundeberg, “Accupuncture-from empiricism to science: the functional background to acupuncture effects in pain and disease,” Med. Hypoth., 45, No. 3, 271–281 (1995).

    Article  CAS  Google Scholar 

  28. A. E. Calogero, “Neurotransmitter regulation of the hypothalamic corticotropin-releasing hormone neuron,” Ann. New York Acad. Sci., 771, 31–40 (1995).

    CAS  Google Scholar 

  29. H. Lai, A. Horita, C. K. Chou, and A. W. Guy, “Low-level microwave irradiation attenuates naloxone-induced withdrawal syndrome in morphine-dependent rats,” Pharmacol., Biochem., Behav., 24, No. 1, 151–153 (1986)

    Article  CAS  Google Scholar 

  30. J. D. Beluzzi, N. Grant, V. Garsky, et al., “Analgesia induced in vivo by central administration of enkephalin in rat,” Nature, 260, 625–626 (1976).

    Article  Google Scholar 

  31. M. J. Millan, R. Przewlock, M. Jerlicz, et al., “Stress-induced release of brain and pituitary β-endorphin: Major role of endorphins in generation of hyperthermia, not analgesia,” Brain Res., 208, No. 2, 325–338 (1981).

    Article  PubMed  CAS  Google Scholar 

  32. S. Amir and Z. Amit, “Endogenous opioid ligands may mediate stress-induced changes in the affective properties of pain-related behavior in rats,” Life Sci., 18, 1143–1152 (1978).

    Article  Google Scholar 

  33. A. S. Shtemberg, M. G. Uzbekov, and S. N. Shikhov, “Some neurotropic effects of low-intensity electromagnetic waves in rats with different typological peculiarities of higher nervous activity,” Zh. Vyssh. Nerv. Deyat., 50, No. 5, 867–877 (2000).

    CAS  Google Scholar 

  34. Yu. M. Kulikovich and Z. A. Tamarova, “Role of opiate receptors in analgesia induced by the action of low-intensity millimeter waves on the acupuncture point,” Med. Perspektyvy, 4, No. 3, 9–14 (1999).

    Google Scholar 

  35. O. Gordienko, A. Radzievsky, A. Cowan, et al., “Delta 1 and kappa-opioid receptor subtypes involved in the hypoalgesic effect of millimeter wave treatment,” in: Abstract Twenty-Fourth Annual Meeting in Cooperation with the European Bioelectromagnetics Association, Canada (2002), p. 27.

Download references

Author information

Authors and Affiliations

  1. Vernadskii Tavricheskii National University, Simferopol’, Crimean Autonomic Republic, Ukraine

    E. N. Chuyan, M. M. Makhonina & T. V. Zayachnikova

Authors
  1. E. N. Chuyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. M. Makhonina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. V. Zayachnikova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. V. Zayachnikova.

Additional information

Neirofiziologiya/Neurophysiology, Vol. 38, No. 1, pp. 52–60, January–February, 2006.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chuyan, E.N., Makhonina, M.M. & Zayachnikova, T.V. Effects of the blockade of the system of opioid peptides on changes in emotional/behavioral reactions of rats induced by the action of extrahigh-frequency electromagnetic radiation in the norm and under conditions of hypokinetic stress. Neurophysiology 38, 45–52 (2006). https://doi.org/10.1007/s11062-006-0025-y

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11062-006-0025-y

Keywords

Search

Navigation