Abstract
We showed that applications of cobalt and zinc salicylates lead to restoration of the impulse activity of a PPa1 neuron of the snail, Helix pomatia, under conditions of the blockade of synaptic transmission by cadmium ions. In the case where a PPa1 neuron demonstrated no background activity and/or under conditions of total isolation of this cell, the above-mentioned salicylates initiate generation of action potentials, as well as exert an excitatory effect on “silent” non-identified cells of the parietal and visceral ganglia. Based on the data obtained, we conclude that the activating effect of cobalt and zinc salicylates on the PPa1 cell is similar to that of the so-called initiating factor (IF), which initiates generation of the burst activity. These effects are independent of the inward calcium current. Using an activator of cAMP phosphodiesterase, imidazole, we showed that the effects of the above salicylates (similar to the effect of IF) are related to the influence of these agents on the system of cyclic nucleotides.
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References
L. M. Koval’ and N. I. Kononenko, “New identified nerve cells of Helix pomatia related to generation of pacemaker activity,” Pavlov Zh. Vyssh. Nerv. Deyat., 42, Issue 6, 1124–1131 (1992).
O. N. Osipenko, “Isolation of a peptide that initiates bursting activity in an identified Helix neuron,” Neirofiziologiya, 16, No. 4, 488–492 (1984).
A. Alevizos, K. R. Weiss, and J. Koester, “Synaptic actions of identified peptidergic neuron R15 in Aplysia,” J. Neurosci., 11, 1263–1281 (1991).
O. N. Osipenko, “Effect of an endogenous peptide that initiates pacemaker activity on an isolated ‘bursting’ Helix neuron,” Neirofiziologiya, 18, No. 4, 552–554 (1986).
O. V. Kostyuchenko and I. I. Korenyuk, “Endogenous pacemaker activity of isolated neurons of the mollusc,” Uch. Zap. Tavrichesk. Nats. Univ., 2, No. 13, 35–42 (2000).
N. I. Kononenko and O. V. Kostyuchenko, “Mechanisms of generation of pacemaker activity by identified Helix neurons,” Neurophysiology, 33, No. 1, 40–47 (2001).
N. I. Kononenko and O. N. Osipenko, “Effects of cadmium ions on bursting activity of an identified Helix neuron,” Neirofiziologiya, 15, No. 3, 307–313 (1983).
N. I. Kononenko, “Modulation of endogenous activity generated by a bursting Helix neuron,” Neirofiziologiya, 9, No. 6, 606–613 (1977).
P. G. Kostyuk, “Study of the metabolic dependence of the function of ion channels in the membrane of nerve cells,” Neirofiziologiya, 16, No. 3, 286–296 (1984).
P. A. Doroshenko, V. A. Dyatlov, L. N. Koval’, et al., “Convergence of signal systems of nerve cells: ion channels and secondary messengers,” in: Cellular Signalling, P. G. Kostyuk (ed.), Nauka, Moscow (1992), pp. 7–13.
Onozuka Minoru, Imai Shizuko, Kuba Kin-ya, et al., “Cyclic AMP-dependent protein phosphorylalion is involved in activation of the potassium current associated with endogenous cellular calcium in Euhadra neurons,” Brain Res., 473, No. 2, 401–405 (1988).
M. Dale and J. C. Foreman, Text of Immunopharmacology [Russian translation], Meditsina, Moscow (1998).
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Neirofiziologiya/Neurophysiology, Vol. 38, No. 1, pp. 11–17, January–February, 2006.
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Korenyuk, I.I., Khusainov, D.R. & Shul’gin, V.F. Cobalt and zinc salicylates as functional analogs of an initiating actor in the molluscan nervous system. Neurophysiology 38, 9–14 (2006). https://doi.org/10.1007/s11062-006-0020-3
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DOI: https://doi.org/10.1007/s11062-006-0020-3