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Intracranial solitary fibrous tumor/hemangiopericytoma: tumor reclassification and assessment of treatment outcome via the 2016 WHO classification

  • Clinical Study
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Abstract

Purpose

As per the 2016 World Health Organization (WHO) guidelines on the classification of central nervous system tumors, solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) constitute a single disease entity, known as SFT/HPC. This study provides a clinical analysis of these tumors and describes the treatment outcomes of SFT/HPCs.

Methods

This retrospective study included 76 patients with histopathologically proven SFT/HPC. Reclassification according to the 2016 WHO guideline was done for patients who were diagnosed with SFT or HPC based on the 2007 WHO classification. Recurrence-free survival (RFS) and overall survival (OS) were evaluated for all patients and subgroups.

Results

The median follow-up period was 77.9 months. The median RFS and OS were 126.5 and 136.8 months, respectively. The 1-, 5-, 10-, and 15-year RFS rates were 93%, 72%, 40%, and 40%, respectively. The 1-, 5-, 10- and 15-year OS rates were 97%, 89%, 54%, and 35%, respectively. In multivariable analyses, stereotactic radiosurgery (SRS; p = 0.009, hazard ratio [HR] 6.986), female sex (p = 0.023, HR 1.76), and age over 45 (p = 0.037, HR 2.74) were associated with shorter RFS. Patients who underwent SRS as initial treatment had a shorter OS than that of patients who underwent primary resection (p < 0.001, HR 12.86).

Conclusions

High-grade tumors tended to have worse OS and occur extracranial metastases earlier than low-grade tumors. The median RFS was not different between grade II and III tumors. Male sex, younger age, and GTR were associated with a better RFS. A history of SRS before tumor resection was associated with a shorter RFS and OS.

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Authors and Affiliations

  1. Department of Neurosurgery, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Pungnab-dong, Songpa-gu, Seoul, 138-736, Republic of Korea

    Dong-Won Shin, Jeong Hoon Kim, Sangjoon Chong, Sang Woo Song, Young-Hoon Kim, Young Hyun Cho & Seok Ho Hong

  2. Department of Pathology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of Korea

    Soo Jeong Nam

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  1. Dong-Won Shin
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Correspondence to Jeong Hoon Kim.

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Because of its retrospective manner, informed consent was waived.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (Asan Medical Center, reference No. 2020-1882) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Shin, DW., Kim, J.H., Chong, S. et al. Intracranial solitary fibrous tumor/hemangiopericytoma: tumor reclassification and assessment of treatment outcome via the 2016 WHO classification. J Neurooncol 154, 171–178 (2021). https://doi.org/10.1007/s11060-021-03733-7

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  • DOI: https://doi.org/10.1007/s11060-021-03733-7

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