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Mouse models of glioblastoma: lessons learned and questions to be answered

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Abstract

Glioblastoma is the most common primary brain tumour in adults. While many patients achieve disease remission following treatment with surgical resection, radiation therapy and chemotherapy, this remission is brief and invariably followed by tumour recurrence and progression. Recent work using mouse models of the disease, coupled with data generated by The Cancer Genome Atlas, have given us new insights into the mechanisms that underlie gliomagenesis and result in glioblastoma heterogeneity. These findings suggest that the treatment of glioblastoma will require a more nuanced understanding of their biology and the employment of targeted therapeutic approaches. In this review, we will summarize the current state of mouse modeling in glioma, with a focus on how these models may inform our understanding of this disease and its treatment.

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The authors have no conflicts of interest to disclose.

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Authors and Affiliations

  1. Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for SickKids, University of Toronto, 30 Bond St, Toronto, ON, M5B 1W8, Canada

    Loury Janbazian & Sunit Das

  2. Keenan Research Centre for Biomedical Research of St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada

    Jason Karamchandani & Sunit Das

  3. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

    Jason Karamchandani & Sunit Das

  4. Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada

    Sunit Das

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  1. Loury Janbazian
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  2. Jason Karamchandani
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  3. Sunit Das
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Correspondence to Sunit Das.

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Janbazian, L., Karamchandani, J. & Das, S. Mouse models of glioblastoma: lessons learned and questions to be answered. J Neurooncol 118, 1–8 (2014). https://doi.org/10.1007/s11060-014-1401-x

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  • DOI: https://doi.org/10.1007/s11060-014-1401-x

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