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MGMT prognostic impact on glioblastoma is dependent on therapeutic modalities

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Abstract

MGMT promoter methylation, which has been correlated with the response to alkylating agents, was investigated in a retrospective series of 219 glioblastomas (GBMs) treated with various modalities. MGMT methylation had no impact on survival for the whole group, but showed a significant advantage (17.1 months vs. 13.1) for patients treated with RT+ adjuvant chemotherapy (relative risk of death (RR) = 0.53; P = 0.041), particularly when patients received CT during the course of RT (MS = 19.9 months vs. 12.5 months; RR = 0.227, P = 0.001). This suggests that the prognostic impact of MGMT methylation is dependent on therapeutic modalities and schedules. MGMT methylation was not correlated with the main molecular alterations, such as 10q loss and p53 expression.

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Acknowledgments

This research was supported by grants from the Institut National du Cancer (PL 046), the Délégation à la Recherche Clinique (AP-HP ; grant n° MUL 03012) and the Ligue Nationale contre le Cancer, comité d’Ile et Villaine. The authors gratefully thank Dr Philippe Broët for statistical expertise, Dr Michèle Kujas for providing histological samples, and Anne-Marie Lekieffre, Muriel Brandel, Marc Ouzounian and Tristan Salmon-Legagneur from the ARTC for their precious assistance.

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Authors and Affiliations

  1. INSERM, U711, Biologie des Interactions Neurones & Glie, Université Pierre et Marie Curie, Faculté de Médecine, Paris, France

    Emmanuelle Crinière, Nathalie Auger, Sibille Everhard, Karima Mokhtari, Jean-Yves Delattre, Khê Hoang-Xuan, Joëlle Thillet & Marc Sanson

  2. Service de Neurologie Mazarin, Groupe Hospitalier Pitié-Salpêtrière, Assistance-Publique Hôpitaux de Paris, 75651, Paris cedex 13, France

    Gentian Kaloshi, Florence Laigle-Donadey, Julie Lejeune, Alexandra Benouaich-Amiel, Jean-Yves Delattre, Khê Hoang-Xuan & Marc Sanson

  3. Laboratoire de Neuropathologie R. Escourolle, Groupe Hospitalier Pitié-Salpêtrière, Paris, France

    Karima Mokhtari

  4. Service d’anatomopathologie, Hôpital Lariboisière, Paris, France

    Marc Polivka

  5. Service de Neurologie Mazarin, Groupe Hospitalier Pitié-Salpêtrière, 47 boulevard de l’Hôpital, 75013, Paris, France

    Marc Sanson

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  1. Emmanuelle Crinière
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  2. Gentian Kaloshi
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  3. Florence Laigle-Donadey
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  7. Sibille Everhard
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  10. Jean-Yves Delattre
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  11. Khê Hoang-Xuan
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  12. Joëlle Thillet
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  13. Marc Sanson
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Correspondence to Marc Sanson.

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Crinière, E., Kaloshi, G., Laigle-Donadey, F. et al. MGMT prognostic impact on glioblastoma is dependent on therapeutic modalities. J Neurooncol 83, 173–179 (2007). https://doi.org/10.1007/s11060-006-9320-0

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  • DOI: https://doi.org/10.1007/s11060-006-9320-0

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