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Glioblastoma

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Malignant Brain Tumors

Abstract

Glioblastoma is the most aggressive and the most common primary malignant brain tumor in adults. Risk factors for glioblastoma are widely elusive and the clinical course is generally fatal. Diagnosis is based on histopathological findings, but assessment of molecular markers such as isocitrate dehydrogenase (IDH) mutations and O6-methylguanyl DNA methyltransferase (MGMT) promoter methylation as well as more extensive molecular profiling is increasingly applied for prognostic subclassification and to individualize treatment approaches. Standard treatment of glioblastoma comprises the classical modalities surgery, radiotherapy, and alkylating agent chemotherapy, but molecularly targeted and immunological approaches are in clinical testing. Future challenges include the molecular dissection of spatial and temporal molecular heterogeneity.

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  1. Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland

    Hans-Georg Wirsching & Michael Weller

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  2. Yale University School of Medicine, New Haven, Connecticut, USA

    Joseph M Piepmeier

  3. Yale School of Medicine, New Haven, Connecticut, USA

    Joachim M. Baehring

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Wirsching, HG., Weller, M. (2017). Glioblastoma. In: Moliterno Gunel, J., Piepmeier, J., Baehring, J. (eds) Malignant Brain Tumors . Springer, Cham. https://doi.org/10.1007/978-3-319-49864-5_18

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