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Atypical teratoid/rhabdoid tumor: the controversy behind radiation therapy

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Abstract

To date, approximately 200 cases of atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system have been described in the literature. This CNS tumor tends to present at an age of less than 3 years, and most patients succumb to their disease within 1 year of diagnosis. Prior to the rise in utilization of immunohistochemical (IHC) testing in the late 1990s, this tumor was likely mistaken as medulloblastoma and treated as such. However, lessons learned from regimens based upon medulloblastoma have revealed that AT/RT requires more aggressive treatment. A significant portion of patients die of local recurrence in spite of aggressive surgery and chemotherapy. As most patients with AT/RT present as infants or young children, radiation therapy has been a less than standard treatment option. However, recent evidence suggests that long-term survival can occur with use of more aggressive treatment approaches including dose-intense chemotherapy as well as adjuvant radiation therapy. A standardized and effective approach to treating this usually fatal tumor remains elusive, and the role of radiation therapy presents a particular dilemma as young patients with this disease may experience devastating late effects of therapy if they achieve a long-term survival. Review of the literature reveals an association between initial radiation therapy and the ability to achieve a prolonged survival. Our review underscores the importance or enrolling patients in multi-institutional prospective studies to further investigate the value of radiation to treat this pediatric neoplasm.

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Authors and Affiliations

  1. Brown Medical School, Brown University, Box G-8288, Providence, RI, 02912, USA

    Sarah E. Squire

  2. Department of Radiation Oncology, Tufts-New England Medical Center, Boston, MA, USA

    Michael D. Chan

  3. Department of Radiation Oncology, Children's Hospital Harvard University, Boston, MA, USA

    Karen J. Marcus

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  1. Sarah E. Squire
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Squire, S.E., Chan, M.D. & Marcus, K.J. Atypical teratoid/rhabdoid tumor: the controversy behind radiation therapy. J Neurooncol 81, 97–111 (2007). https://doi.org/10.1007/s11060-006-9196-z

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