Abstract
We observed three neoplasms with completely different histologies: malignant fibrous histiocytoma (MFH), atypical meningioma (AM), and glioblastoma (GB), developing in a patient with Li–Fraumeni syndrome. By using a combined molecular approach we performed molecular characterization of all three tumours. Data obtained showed an interesting molecular background of the AM and GB. AM showed TP53mutations and a 22q loss of heterozygosity (LOH). GB showed epidermal growth factor receptor (EGFR) amplification and TP53 mutations, whereas P16, PTEN, Rbwere intact in terms of LOH and/or multiplex PCR (polymerase chain reaction) analysis. Additionally, GB has a 1q LOH, which is an extremely rare alteration in glioblastomas. Identical 1q LOH was also observed in MFH.
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Rieske, P., Zakrzewska, M., Biernat, W. et al. Atypical molecular background of glioblastoma and meningioma developed in a patient with Li–Fraumeni syndrome . J Neurooncol 71, 27–30 (2005). https://doi.org/10.1007/s11060-004-9181-3
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DOI: https://doi.org/10.1007/s11060-004-9181-3